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Article: Telomere capture stabilizes chromosome breakage

TitleTelomere capture stabilizes chromosome breakage
Authors
Issue Date1993
PublisherNature Publishing Group. The Journal's web site is located at http://www.genetics.nature.com
Citation
Nature Genetics, 1993, v. 4 n. 3, p. 252-255 How to Cite?
AbstractTerminal deletions are found frequently in both malignancies and clinically recognizable deletion syndromes in man. Little is known, particularly in cancer, of the specific mechanisms which lead to the generation of deleted chromosomes or the process by which these broken chromosomes are stabilized. We demonstrate that several examples of apparent terminal deletions are, in fact, subtelomeric translocations which were not detectable using conventional cytogenetics. The unexpectedly high frequency of this phenomenon and the diversity of partner chromosomes involved in the subtelomeric translocations is consistent with a model in which telomere capture can stabilize chromosome breakage in man.
Persistent Identifierhttp://hdl.handle.net/10722/150702
ISSN
2015 Impact Factor: 31.616
2015 SCImago Journal Rankings: 23.762
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMeltzer, PSen_US
dc.contributor.authorGuan, XYen_US
dc.contributor.authorTrent, JMen_US
dc.date.accessioned2012-06-26T06:09:00Z-
dc.date.available2012-06-26T06:09:00Z-
dc.date.issued1993en_US
dc.identifier.citationNature Genetics, 1993, v. 4 n. 3, p. 252-255en_US
dc.identifier.issn1061-4036en_US
dc.identifier.urihttp://hdl.handle.net/10722/150702-
dc.description.abstractTerminal deletions are found frequently in both malignancies and clinically recognizable deletion syndromes in man. Little is known, particularly in cancer, of the specific mechanisms which lead to the generation of deleted chromosomes or the process by which these broken chromosomes are stabilized. We demonstrate that several examples of apparent terminal deletions are, in fact, subtelomeric translocations which were not detectable using conventional cytogenetics. The unexpectedly high frequency of this phenomenon and the diversity of partner chromosomes involved in the subtelomeric translocations is consistent with a model in which telomere capture can stabilize chromosome breakage in man.en_US
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.genetics.nature.comen_US
dc.relation.ispartofNature Geneticsen_US
dc.subject.meshChromosome Deletionen_US
dc.subject.meshChromosomes, Human, Pair 6en_US
dc.subject.meshHumansen_US
dc.subject.meshHybrid Cells - Ultrastructureen_US
dc.subject.meshIn Situ Hybridization, Fluorescenceen_US
dc.subject.meshMelanoma - Genetics - Ultrastructureen_US
dc.subject.meshModels, Geneticen_US
dc.subject.meshTelomere - Ultrastructureen_US
dc.subject.meshTranslocation, Geneticen_US
dc.titleTelomere capture stabilizes chromosome breakageen_US
dc.typeArticleen_US
dc.identifier.emailGuan, XY:xyguan@hkucc.hku.hken_US
dc.identifier.authorityGuan, XY=rp00454en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1038/ng0793-252en_US
dc.identifier.pmid8358433-
dc.identifier.scopuseid_2-s2.0-0027325817en_US
dc.identifier.volume4en_US
dc.identifier.issue3en_US
dc.identifier.spage252en_US
dc.identifier.epage255en_US
dc.identifier.isiWOS:A1993LJ84200012-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridMeltzer, PS=7102464641en_US
dc.identifier.scopusauthoridGuan, XY=7201463221en_US
dc.identifier.scopusauthoridTrent, JM=7201692482en_US

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