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Article: Rapid generation of region specific probes by chromosome microdissection and their application

TitleRapid generation of region specific probes by chromosome microdissection and their application
Authors
Issue Date1992
PublisherNature Publishing Group. The Journal's web site is located at http://www.genetics.nature.com
Citation
Nature Genetics, 1992, v. 1 n. 1, p. 24-28 How to Cite?
AbstractThe strategy presented here to identify unequivocally cryptic chromosomal rearrangements has relevance to both prenatal and postnatal cytogenetic analysis as well as the analysis of tumour-associated chromosome rearrangements. Microdissection and in vitro amplification of specific chromosomal regions are performed, followed by labelling for fluorescent in situ hybridization (FISH) to normal metaphase chromosomes (Micro-FISH). Micro-FISH probes have been used successfully to determine the derivation of chromosome segments unidentifiable by standard chromosome banding analysis. Micro-FISH probes (created in less than 24 hours) now make it possible to identify explicitly the chromosome constitution of virtually all cytologically visible chromosome rearrangements.
Persistent Identifierhttp://hdl.handle.net/10722/150698
ISSN
2015 Impact Factor: 31.616
2015 SCImago Journal Rankings: 23.762
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorMeltzer, PSen_US
dc.contributor.authorGuan, XYen_US
dc.contributor.authorBurgess, Aen_US
dc.contributor.authorTrent, JMen_US
dc.date.accessioned2012-06-26T06:08:55Z-
dc.date.available2012-06-26T06:08:55Z-
dc.date.issued1992en_US
dc.identifier.citationNature Genetics, 1992, v. 1 n. 1, p. 24-28en_US
dc.identifier.issn1061-4036en_US
dc.identifier.urihttp://hdl.handle.net/10722/150698-
dc.description.abstractThe strategy presented here to identify unequivocally cryptic chromosomal rearrangements has relevance to both prenatal and postnatal cytogenetic analysis as well as the analysis of tumour-associated chromosome rearrangements. Microdissection and in vitro amplification of specific chromosomal regions are performed, followed by labelling for fluorescent in situ hybridization (FISH) to normal metaphase chromosomes (Micro-FISH). Micro-FISH probes have been used successfully to determine the derivation of chromosome segments unidentifiable by standard chromosome banding analysis. Micro-FISH probes (created in less than 24 hours) now make it possible to identify explicitly the chromosome constitution of virtually all cytologically visible chromosome rearrangements.en_US
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.genetics.nature.comen_US
dc.relation.ispartofNature Geneticsen_US
dc.subject.meshBase Sequenceen_US
dc.subject.meshChromosome Aberrationsen_US
dc.subject.meshChromosome Deletionen_US
dc.subject.meshChromosomes, Human - Ultrastructureen_US
dc.subject.meshDna - Geneticsen_US
dc.subject.meshDna Probesen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene Rearrangementen_US
dc.subject.meshHumansen_US
dc.subject.meshIn Situ Hybridization, Fluorescence - Methodsen_US
dc.subject.meshMolecular Probe Techniquesen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshNeoplasms - Geneticsen_US
dc.subject.meshPolymerase Chain Reactionen_US
dc.subject.meshPregnancyen_US
dc.subject.meshPrenatal Diagnosisen_US
dc.subject.meshTranslocation, Geneticen_US
dc.titleRapid generation of region specific probes by chromosome microdissection and their applicationen_US
dc.typeArticleen_US
dc.identifier.emailGuan, XY:xyguan@hkucc.hku.hken_US
dc.identifier.authorityGuan, XY=rp00454en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid1301994-
dc.identifier.scopuseid_2-s2.0-0026849710en_US
dc.identifier.volume1en_US
dc.identifier.issue1en_US
dc.identifier.spage24en_US
dc.identifier.epage28en_US
dc.identifier.isiWOS:A1992JC97800007-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridMeltzer, PS=7102464641en_US
dc.identifier.scopusauthoridGuan, XY=7201463221en_US
dc.identifier.scopusauthoridBurgess, A=7201495330en_US
dc.identifier.scopusauthoridTrent, JM=7201692482en_US

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