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Article: Detection of distinct Epstein-Barr virus genotypes in NPC biopsies from Southern Chinese and Caucasians

TitleDetection of distinct Epstein-Barr virus genotypes in NPC biopsies from Southern Chinese and Caucasians
Authors
Lung, MLChang, GC
Issue Date1992
PublisherJohn Wiley & Sons, Inc.. The Journal's web site is located at http://www3.interscience.wiley.com/journal/29331/home
Citation
International Journal Of Cancer, 1992, v. 52 n. 1, p. 34-37 How to Cite?
DOI: http://dx.doi.org/10.1002/ijc.2910520108
AbstractUsing the polymerase chain reaction (PCR) to analyze paraffin sections from 12 Caucasian patients, we detected only the prototype F Epstein-Barr virus (EBV) in 10 specimens from patients with nasopharyngeal carcinoma (NPC). This is in contrast to the higher frequency of association of 'f' variants in NPC biopsies from Southern Chinese. The results of EBV genotyping support evidence that the EBV strains associated with NPC in the Southern Chinese population differ from those found in Caucasians. DNA sequencing confirmed that a simple point mutation is responsible for the restriction-fragment length polymorphism which distinguishes the prototype F virus from the 'f' variant.
Persistent Identifierhttp://hdl.handle.net/10722/150696
ISSN
0020-7136
2021 Impact Factor: 7.316
2020 SCImago Journal Rankings: 2.475
ISI Accession Number ID
WOS:A1992JJ72300007

 

DC FieldValueLanguage
dc.contributor.authorLung, MLen_US
dc.contributor.authorChang, GCen_US
dc.date.accessioned2012-06-26T06:08:53Z-
dc.date.available2012-06-26T06:08:53Z-
dc.date.issued1992en_US
dc.identifier.citationInternational Journal Of Cancer, 1992, v. 52 n. 1, p. 34-37en_US
dc.identifier.issn0020-7136en_US
dc.identifier.urihttp://hdl.handle.net/10722/150696-
dc.description.abstractUsing the polymerase chain reaction (PCR) to analyze paraffin sections from 12 Caucasian patients, we detected only the prototype F Epstein-Barr virus (EBV) in 10 specimens from patients with nasopharyngeal carcinoma (NPC). This is in contrast to the higher frequency of association of 'f' variants in NPC biopsies from Southern Chinese. The results of EBV genotyping support evidence that the EBV strains associated with NPC in the Southern Chinese population differ from those found in Caucasians. DNA sequencing confirmed that a simple point mutation is responsible for the restriction-fragment length polymorphism which distinguishes the prototype F virus from the 'f' variant.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc.. The Journal's web site is located at http://www3.interscience.wiley.com/journal/29331/homeen_US
dc.relation.ispartofInternational Journal of Canceren_US
dc.subject.meshAsian Continental Ancestry Groupen_US
dc.subject.meshBase Sequenceen_US
dc.subject.meshBiopsyen_US
dc.subject.meshCarcinoma - Ethnology - Microbiologyen_US
dc.subject.meshChinaen_US
dc.subject.meshEuropean Continental Ancestry Groupen_US
dc.subject.meshGenotypeen_US
dc.subject.meshHerpesvirus 4, Human - Geneticsen_US
dc.subject.meshHumansen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshNasopharyngeal Neoplasms - Ethnology - Microbiologyen_US
dc.titleDetection of distinct Epstein-Barr virus genotypes in NPC biopsies from Southern Chinese and Caucasiansen_US
dc.typeArticleen_US
dc.identifier.emailLung, ML:mlilung@hku.hken_US
dc.identifier.authorityLung, ML=rp00300en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/ijc.2910520108-
dc.identifier.pmid1323539-
dc.identifier.scopuseid_2-s2.0-0026707950en_US
dc.identifier.volume52en_US
dc.identifier.issue1en_US
dc.identifier.spage34en_US
dc.identifier.epage37en_US
dc.identifier.isiWOS:A1992JJ72300007-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLung, ML=7006411788en_US
dc.identifier.scopusauthoridChang, GC=7402309089en_US
dc.identifier.issnl0020-7136-

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