File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Detection and prevalence of the 'f' variant of Epstein-Barr virus in Southern China

TitleDetection and prevalence of the 'f' variant of Epstein-Barr virus in Southern China
Authors
Issue Date1991
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yviro
Citation
Virology, 1991, v. 185 n. 1, p. 67-71 How to Cite?
AbstractThe 'f' variant of Epstein-Barr virus (EBV) may have an association with the development and/or maintenance of nasopharyngeal carcinoma (NPC) among Southern Chinese. This variant is detected at a higher frequency among individuals with elevated IgA antibody levels against DBV capsid antigen who have no detectable NPC and in NPC patients as compared to healthy individuals or patients who are in remission for NPC for over 3 years. Conversion or replacement of the f variant by the prototype BamHI F virus usually occurs by 3 to 4 years after radiotherapy. By 5 years post-therapy the majority of people in remission for NPC no longer harbor the f variant in their oropharynx. Eradication of this f variant, however, does not appear essential for maintenance of a disease-free state since several patients harboring this variant were in remission for NPC for up to 21 years. The virus strain detected directly in the nasopharynx is not always identical to that seen in the oropharynx. Dual infection was commonly observed in throat washings of NPC patients although the biopsy from tumors harbored unique strains of EBV.
Persistent Identifierhttp://hdl.handle.net/10722/150694
ISSN
2015 Impact Factor: 3.2
2015 SCImago Journal Rankings: 1.805
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLung, MLen_US
dc.contributor.authorLam, WPen_US
dc.contributor.authorSham, Jen_US
dc.contributor.authorChoy, Den_US
dc.contributor.authorYongSheng, Zen_US
dc.contributor.authorGuo, HYen_US
dc.contributor.authorNg, MHen_US
dc.date.accessioned2012-06-26T06:08:53Z-
dc.date.available2012-06-26T06:08:53Z-
dc.date.issued1991en_US
dc.identifier.citationVirology, 1991, v. 185 n. 1, p. 67-71en_US
dc.identifier.issn0042-6822en_US
dc.identifier.urihttp://hdl.handle.net/10722/150694-
dc.description.abstractThe 'f' variant of Epstein-Barr virus (EBV) may have an association with the development and/or maintenance of nasopharyngeal carcinoma (NPC) among Southern Chinese. This variant is detected at a higher frequency among individuals with elevated IgA antibody levels against DBV capsid antigen who have no detectable NPC and in NPC patients as compared to healthy individuals or patients who are in remission for NPC for over 3 years. Conversion or replacement of the f variant by the prototype BamHI F virus usually occurs by 3 to 4 years after radiotherapy. By 5 years post-therapy the majority of people in remission for NPC no longer harbor the f variant in their oropharynx. Eradication of this f variant, however, does not appear essential for maintenance of a disease-free state since several patients harboring this variant were in remission for NPC for up to 21 years. The virus strain detected directly in the nasopharynx is not always identical to that seen in the oropharynx. Dual infection was commonly observed in throat washings of NPC patients although the biopsy from tumors harbored unique strains of EBV.en_US
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yviroen_US
dc.relation.ispartofVirologyen_US
dc.subject.meshBase Sequenceen_US
dc.subject.meshBiopsyen_US
dc.subject.meshBlotting, Southernen_US
dc.subject.meshChinaen_US
dc.subject.meshDna, Viral - Genetics - Isolation & Purificationen_US
dc.subject.meshGenetic Variationen_US
dc.subject.meshHerpesvirus 4, Human - Genetics - Isolation & Purificationen_US
dc.subject.meshHumansen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshNasopharyngeal Neoplasms - Microbiology - Pathologyen_US
dc.subject.meshPharynx - Microbiologyen_US
dc.subject.meshPolymerase Chain Reaction - Methodsen_US
dc.subject.meshPrevalenceen_US
dc.subject.meshReference Valuesen_US
dc.subject.meshRepetitive Sequences, Nucleic Aciden_US
dc.subject.meshRestriction Mappingen_US
dc.titleDetection and prevalence of the 'f' variant of Epstein-Barr virus in Southern Chinaen_US
dc.typeArticleen_US
dc.identifier.emailLung, ML:mlilung@hku.hken_US
dc.identifier.authorityLung, ML=rp00300en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0042-6822(91)90754-Yen_US
dc.identifier.pmid1656606-
dc.identifier.scopuseid_2-s2.0-0025950797en_US
dc.identifier.hkuros27097-
dc.identifier.volume185en_US
dc.identifier.issue1en_US
dc.identifier.spage67en_US
dc.identifier.epage71en_US
dc.identifier.isiWOS:A1991GJ98000009-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLung, ML=7006411788en_US
dc.identifier.scopusauthoridLam, WP=7203021904en_US
dc.identifier.scopusauthoridSham, J=24472255400en_US
dc.identifier.scopusauthoridChoy, D=8663654500en_US
dc.identifier.scopusauthoridYongSheng, Z=6506399602en_US
dc.identifier.scopusauthoridGuo, HY=34769789200en_US
dc.identifier.scopusauthoridNg, MH=7202076421en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats