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Article: Chromosome 22q11.2 Interstitial deletions among childhood-onset schizophrenics and 'multidimensionally impaired'

TitleChromosome 22q11.2 Interstitial deletions among childhood-onset schizophrenics and 'multidimensionally impaired'
Authors
Issue Date1998
Citation
American Journal Of Medical Genetics - Neuropsychiatric Genetics, 1998, v. 81 n. 1, p. 41-43 How to Cite?
AbstractSince its first description almost a century ago schizophrenia with childhood onset, a rare yet devastating disorder, has been diagnosed in children as young as age 5. Recently, the velocardiofacial syndrome, whose underlying cause is interstitial deletions of 22q11.2, was found in 2 of 100 cases of schizophrenics with adult onset [Karayiorgou et al., Proc Natl Acad Sci USA 92: 7612-7616, 1995]. No study has documented the prevalence of velocardiofacial syndrome and the 22q11.2 deletion in a population of schizophrenics with childhood onset. Here we describe the result of such a study in a sample originally selected for a trial of atypical antipsychotic drugs. A separate group of patients was also included in the study; they can best be accounted for as a variant of childhood-onset schizophrenia (COS) and had been provisionally termed 'multidimensionally impaired.' Fluorescent in situ hybridization screening of 32 COS and 21 multidimensionally impaired patients revealed 1 COS patient with an interstitial deletion spanning at least 2.5 megabases.
Persistent Identifierhttp://hdl.handle.net/10722/150681
ISSN
2003 Impact Factor: -999.999
2009 SCImago Journal Rankings: 1.100
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYan, Wen_US
dc.contributor.authorJacobsen, LKen_US
dc.contributor.authorKrasnewich, DMen_US
dc.contributor.authorGuan, XYen_US
dc.contributor.authorLenane, MCen_US
dc.contributor.authorPaul, SPen_US
dc.contributor.authorDalwadi, HNen_US
dc.contributor.authorZhang, Hen_US
dc.contributor.authorLong, RTen_US
dc.contributor.authorKumra, Sen_US
dc.contributor.authorMartin, BMen_US
dc.contributor.authorScambler, PJen_US
dc.contributor.authorTrent, JMen_US
dc.contributor.authorSidransky, Een_US
dc.contributor.authorGinns, EIen_US
dc.contributor.authorRapoport, JLen_US
dc.date.accessioned2012-06-26T06:08:38Z-
dc.date.available2012-06-26T06:08:38Z-
dc.date.issued1998en_US
dc.identifier.citationAmerican Journal Of Medical Genetics - Neuropsychiatric Genetics, 1998, v. 81 n. 1, p. 41-43en_US
dc.identifier.issn0148-7299en_US
dc.identifier.urihttp://hdl.handle.net/10722/150681-
dc.description.abstractSince its first description almost a century ago schizophrenia with childhood onset, a rare yet devastating disorder, has been diagnosed in children as young as age 5. Recently, the velocardiofacial syndrome, whose underlying cause is interstitial deletions of 22q11.2, was found in 2 of 100 cases of schizophrenics with adult onset [Karayiorgou et al., Proc Natl Acad Sci USA 92: 7612-7616, 1995]. No study has documented the prevalence of velocardiofacial syndrome and the 22q11.2 deletion in a population of schizophrenics with childhood onset. Here we describe the result of such a study in a sample originally selected for a trial of atypical antipsychotic drugs. A separate group of patients was also included in the study; they can best be accounted for as a variant of childhood-onset schizophrenia (COS) and had been provisionally termed 'multidimensionally impaired.' Fluorescent in situ hybridization screening of 32 COS and 21 multidimensionally impaired patients revealed 1 COS patient with an interstitial deletion spanning at least 2.5 megabases.en_US
dc.languageengen_US
dc.relation.ispartofAmerican Journal of Medical Genetics - Neuropsychiatric Geneticsen_US
dc.subject.meshChilden_US
dc.subject.meshChild, Preschoolen_US
dc.subject.meshChromosome Aberrationsen_US
dc.subject.meshChromosome Disordersen_US
dc.subject.meshChromosomes, Human, Pair 22en_US
dc.subject.meshDigeorge Syndrome - Geneticsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGene Deletionen_US
dc.subject.meshHumansen_US
dc.subject.meshIn Situ Hybridization, Fluorescenceen_US
dc.subject.meshIntelligence Testsen_US
dc.subject.meshMaleen_US
dc.subject.meshSchizophrenia - Geneticsen_US
dc.subject.meshSocial Isolationen_US
dc.titleChromosome 22q11.2 Interstitial deletions among childhood-onset schizophrenics and 'multidimensionally impaired'en_US
dc.typeArticleen_US
dc.identifier.emailGuan, XY:xyguan@hkucc.hku.hken_US
dc.identifier.authorityGuan, XY=rp00454en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/(SICI)1096-8628(19980207)81:1<41::AID-AJMG8>3.0.CO;2-Qen_US
dc.identifier.pmid9514586-
dc.identifier.scopuseid_2-s2.0-0007482654en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0007482654&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume81en_US
dc.identifier.issue1en_US
dc.identifier.spage41en_US
dc.identifier.epage43en_US
dc.identifier.isiWOS:000072267000008-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridYan, W=7402221404en_US
dc.identifier.scopusauthoridJacobsen, LK=16144675600en_US
dc.identifier.scopusauthoridKrasnewich, DM=16211947300en_US
dc.identifier.scopusauthoridGuan, XY=7201463221en_US
dc.identifier.scopusauthoridLenane, MC=7004722434en_US
dc.identifier.scopusauthoridPaul, SP=7401979510en_US
dc.identifier.scopusauthoridDalwadi, HN=6603313111en_US
dc.identifier.scopusauthoridZhang, H=7409194743en_US
dc.identifier.scopusauthoridLong, RT=7401715808en_US
dc.identifier.scopusauthoridKumra, S=6603693664en_US
dc.identifier.scopusauthoridMartin, BM=7402931915en_US
dc.identifier.scopusauthoridScambler, PJ=7006489319en_US
dc.identifier.scopusauthoridTrent, JM=7201692482en_US
dc.identifier.scopusauthoridSidransky, E=7005375809en_US
dc.identifier.scopusauthoridGinns, EI=7005267996en_US
dc.identifier.scopusauthoridRapoport, JL=7102502816en_US

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