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Article: The biology of EBV infection in human epithelial cells

TitleThe biology of EBV infection in human epithelial cells
Authors
KeywordsBiology Of Infection
Ebv
Epithelial Cells
Nasopharyngeal Carcinoma
Issue Date2012
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/semcancer
Citation
Seminars In Cancer Biology, 2012, v. 22 n. 2, p. 137-143 How to Cite?
AbstractEBV-associated human malignancies may originate from B cells and epithelial cells. EBV readily infects B cells in vitro and transforms them into proliferative lymphoblastoid cell lines. In contrast, infection of human epithelial cells in vitro with EBV has been difficult to achieve. The lack of experimental human epithelial cell systems for EBV infection has hampered the understanding of biology of EBV infection in epithelial cells. The recent success to infect human epithelial cells with EBV in vitro has allowed systematic investigations into routes of EBV entry, regulation of latent and lytic EBV infection, and persistence of EBV infection in infected epithelial cells. Understanding the biology of EBV infection in human epithelial cells will provide important insights to the role of EBV infection in the pathogenesis of EBV-associated epithelial malignancies including nasopharyngeal carcinoma and gastric carcinoma. © 2012 Elsevier Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/149782
ISSN
2015 Impact Factor: 9.955
2015 SCImago Journal Rankings: 6.320
ISI Accession Number ID
Funding AgencyGrant Number
Research Grants Council of Hong Kong (AoE NPC)AoE/M-06/08
GRF7770/07M
776608M
777809
779810
780911
471610
471211
CRCG, University of Hong Kong
Funding Information:

This work is supported by the following funding: Research Grants Council of Hong Kong (AoE NPC; grant number: AoE/M-06/08); (GRF grant numbers: 7770/07M, 776608M, 777809, 779810, 780911, 471610, 471211): CRCG Grant, University of Hong Kong.

References
Grants

 

DC FieldValueLanguage
dc.contributor.authorTsao, SWen_US
dc.contributor.authorTsang, CMen_US
dc.contributor.authorPang, PSen_US
dc.contributor.authorZhang, Gen_US
dc.contributor.authorChen, Hen_US
dc.contributor.authorLo, KWen_US
dc.date.accessioned2012-06-26T05:58:31Z-
dc.date.available2012-06-26T05:58:31Z-
dc.date.issued2012en_US
dc.identifier.citationSeminars In Cancer Biology, 2012, v. 22 n. 2, p. 137-143en_US
dc.identifier.issn1044-579Xen_US
dc.identifier.urihttp://hdl.handle.net/10722/149782-
dc.description.abstractEBV-associated human malignancies may originate from B cells and epithelial cells. EBV readily infects B cells in vitro and transforms them into proliferative lymphoblastoid cell lines. In contrast, infection of human epithelial cells in vitro with EBV has been difficult to achieve. The lack of experimental human epithelial cell systems for EBV infection has hampered the understanding of biology of EBV infection in epithelial cells. The recent success to infect human epithelial cells with EBV in vitro has allowed systematic investigations into routes of EBV entry, regulation of latent and lytic EBV infection, and persistence of EBV infection in infected epithelial cells. Understanding the biology of EBV infection in human epithelial cells will provide important insights to the role of EBV infection in the pathogenesis of EBV-associated epithelial malignancies including nasopharyngeal carcinoma and gastric carcinoma. © 2012 Elsevier Ltd.en_US
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/semcanceren_US
dc.relation.ispartofSeminars in Cancer Biologyen_US
dc.subjectBiology Of Infectionen_US
dc.subjectEbven_US
dc.subjectEpithelial Cellsen_US
dc.subjectNasopharyngeal Carcinomaen_US
dc.titleThe biology of EBV infection in human epithelial cellsen_US
dc.typeArticleen_US
dc.identifier.emailTsao, SW:gswtsao@hkucc.hku.hken_US
dc.identifier.authorityTsao, SW=rp00399en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.semcancer.2012.02.004en_US
dc.identifier.pmid22497025-
dc.identifier.scopuseid_2-s2.0-84862816141-
dc.identifier.hkuros208495-
dc.identifier.hkuros195045-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84857781877&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume22en_US
dc.identifier.issue2en_US
dc.identifier.spage137en_US
dc.identifier.epage143en_US
dc.identifier.isiWOS:000302450100008-
dc.publisher.placeUnited Kingdomen_US
dc.relation.projectCentre for Nasopharyngeal Carcinoma Research-
dc.identifier.scopusauthoridTsao, SW=7102813116en_US
dc.identifier.scopusauthoridTsang, CM=24831236400en_US
dc.identifier.scopusauthoridPang, PS=54997575500en_US
dc.identifier.scopusauthoridZhang, G=54995821900en_US
dc.identifier.scopusauthoridChen, H=54997141100en_US
dc.identifier.scopusauthoridLo, KW=7402101603en_US

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