Article: The biology of EBV infection in human epithelial cells
| Title | The biology of EBV infection in human epithelial cells | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Authors | Tsao, SW1 Tsang, CM1 Pang, PS1 Zhang, G1 Chen, H1 Lo, KW2 | ||||||||
| Keywords | Biology Of Infection Ebv Epithelial Cells Nasopharyngeal Carcinoma | ||||||||
| Issue Date | 2012 | ||||||||
| Publisher | Academic Press. The Journal's web site is located at http://www.elsevier.com/locate/semcancer | ||||||||
| Citation | Seminars In Cancer Biology, 2012, v. 22 n. 2, p. 137-143 [How to Cite?] DOI: http://dx.doi.org/10.1016/j.semcancer.2012.02.004 | ||||||||
| Abstract | EBV-associated human malignancies may originate from B cells and epithelial cells. EBV readily infects B cells in vitro and transforms them into proliferative lymphoblastoid cell lines. In contrast, infection of human epithelial cells in vitro with EBV has been difficult to achieve. The lack of experimental human epithelial cell systems for EBV infection has hampered the understanding of biology of EBV infection in epithelial cells. The recent success to infect human epithelial cells with EBV in vitro has allowed systematic investigations into routes of EBV entry, regulation of latent and lytic EBV infection, and persistence of EBV infection in infected epithelial cells. Understanding the biology of EBV infection in human epithelial cells will provide important insights to the role of EBV infection in the pathogenesis of EBV-associated epithelial malignancies including nasopharyngeal carcinoma and gastric carcinoma. © 2012 Elsevier Ltd. | ||||||||
| ISSN | 1044-579X 2011 Impact Factor: 6.475 2011 SCImago Journal Rankings: 1.288 | ||||||||
| DOI | http://dx.doi.org/10.1016/j.semcancer.2012.02.004 | ||||||||
| ISI Accession Number ID | WOS:000302450100008
Funding Information: This work is supported by the following funding: Research Grants Council of Hong Kong (AoE NPC; grant number: AoE/M-06/08); (GRF grant numbers: 7770/07M, 776608M, 777809, 779810, 780911, 471610, 471211): CRCG Grant, University of Hong Kong. | ||||||||
| References | References in Scopus | ||||||||
| Grants | Centre for Nasopharyngeal Carcinoma Research |
| dc.contributor.author | Tsao, SW | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| dc.contributor.author | Tsang, CM | ||||||||
| dc.contributor.author | Pang, PS | ||||||||
| dc.contributor.author | Zhang, G | ||||||||
| dc.contributor.author | Chen, H | ||||||||
| dc.contributor.author | Lo, KW | ||||||||
| dc.date.accessioned | 2012-06-26T05:58:31Z | ||||||||
| dc.date.available | 2012-06-26T05:58:31Z | ||||||||
| dc.date.issued | 2012 | ||||||||
| dc.description.abstract | EBV-associated human malignancies may originate from B cells and epithelial cells. EBV readily infects B cells in vitro and transforms them into proliferative lymphoblastoid cell lines. In contrast, infection of human epithelial cells in vitro with EBV has been difficult to achieve. The lack of experimental human epithelial cell systems for EBV infection has hampered the understanding of biology of EBV infection in epithelial cells. The recent success to infect human epithelial cells with EBV in vitro has allowed systematic investigations into routes of EBV entry, regulation of latent and lytic EBV infection, and persistence of EBV infection in infected epithelial cells. Understanding the biology of EBV infection in human epithelial cells will provide important insights to the role of EBV infection in the pathogenesis of EBV-associated epithelial malignancies including nasopharyngeal carcinoma and gastric carcinoma. © 2012 Elsevier Ltd. | ||||||||
| dc.description.grant | Centre for Nasopharyngeal Carcinoma Research | ||||||||
| dc.description.grantcode | 101179 | ||||||||
| dc.description.nature | Link_to_subscribed_fulltext | ||||||||
| dc.identifier.citation | Seminars In Cancer Biology, 2012, v. 22 n. 2, p. 137-143 [How to Cite?] DOI: http://dx.doi.org/10.1016/j.semcancer.2012.02.004 | ||||||||
| dc.identifier.doi | http://dx.doi.org/10.1016/j.semcancer.2012.02.004 | ||||||||
| dc.identifier.epage | 143 | ||||||||
| dc.identifier.hkuros | 208495 | ||||||||
| dc.identifier.isi | WOS:000302450100008
Funding Information: This work is supported by the following funding: Research Grants Council of Hong Kong (AoE NPC; grant number: AoE/M-06/08); (GRF grant numbers: 7770/07M, 776608M, 777809, 779810, 780911, 471610, 471211): CRCG Grant, University of Hong Kong. | ||||||||
| dc.identifier.issn | 1044-579X 2011 Impact Factor: 6.475 2011 SCImago Journal Rankings: 1.288 | ||||||||
| dc.identifier.issue | 2 | ||||||||
| dc.identifier.pmid | 22497025 | ||||||||
| dc.identifier.scopus | eid_2-s2.0-84862816141 | ||||||||
| dc.identifier.spage | 137 | ||||||||
| dc.identifier.uri | http://hdl.handle.net/10722/149782 | ||||||||
| dc.identifier.volume | 22 | ||||||||
| dc.language | eng | ||||||||
| dc.publisher | Academic Press. The Journal's web site is located at http://www.elsevier.com/locate/semcancer | ||||||||
| dc.publisher.place | United Kingdom | ||||||||
| dc.relation.ispartof | Seminars in Cancer Biology | ||||||||
| dc.relation.references | References in Scopus | ||||||||
| dc.subject | Biology Of Infection | ||||||||
| dc.subject | Ebv | ||||||||
| dc.subject | Epithelial Cells | ||||||||
| dc.subject | Nasopharyngeal Carcinoma | ||||||||
| dc.title | The biology of EBV infection in human epithelial cells | ||||||||
| dc.type | Article |
Author Affiliations
- The University of Hong Kong Li Ka Shing Faculty of Medicine
- Chinese University of Hong Kong