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Article: The spider effect: Morphological and orienting classification of microglia in response to stimuli in vivo

TitleThe spider effect: Morphological and orienting classification of microglia in response to stimuli in vivo
Authors
Issue Date2012
PublisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.action
Citation
PLoS ONE, 2012, v. 7 n. 2, article no. e30763 How to Cite?
AbstractThe different morphological stages of microglial activation have not yet been described in detail. We transected the olfactory bulb of rats and examined the activation of the microglial system histologically. Six stages of bidirectional microglial activation (A) and deactivation (R) were observed: from stage 1A to 6A, the cell body size increased, the cell process number decreased, and the cell processes retracted and thickened, orienting toward the direction of the injury site; until stage 6A, when all processes disappeared. In contrast, in deactivation stages 6R to 1R, the microglia returned to the original site exhibiting a stepwise retransformation to the original morphology. Thin highly branched processes re-formed in stage 1R, similar to those in stage 1A. This reverse transformation mirrored the forward transformation except in stages 6R to 1R: cells showed multiple nuclei which were slowly absorbed. Our findings support a morphologically defined stepwise activation and deactivation of microglia cells. © 2012 Jonas et al.
Persistent Identifierhttp://hdl.handle.net/10722/149781
ISSN
2015 Impact Factor: 3.057
2015 SCImago Journal Rankings: 1.395
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorJonas, RAen_HK
dc.contributor.authorYuan, TFen_HK
dc.contributor.authorLiang, YXen_HK
dc.contributor.authorJonas, JBen_HK
dc.contributor.authorTay, DKCen_HK
dc.contributor.authorEllisBehnke, RGen_HK
dc.date.accessioned2012-06-26T05:58:30Z-
dc.date.available2012-06-26T05:58:30Z-
dc.date.issued2012en_HK
dc.identifier.citationPLoS ONE, 2012, v. 7 n. 2, article no. e30763en_HK
dc.identifier.issn1932-6203en_HK
dc.identifier.urihttp://hdl.handle.net/10722/149781-
dc.description.abstractThe different morphological stages of microglial activation have not yet been described in detail. We transected the olfactory bulb of rats and examined the activation of the microglial system histologically. Six stages of bidirectional microglial activation (A) and deactivation (R) were observed: from stage 1A to 6A, the cell body size increased, the cell process number decreased, and the cell processes retracted and thickened, orienting toward the direction of the injury site; until stage 6A, when all processes disappeared. In contrast, in deactivation stages 6R to 1R, the microglia returned to the original site exhibiting a stepwise retransformation to the original morphology. Thin highly branched processes re-formed in stage 1R, similar to those in stage 1A. This reverse transformation mirrored the forward transformation except in stages 6R to 1R: cells showed multiple nuclei which were slowly absorbed. Our findings support a morphologically defined stepwise activation and deactivation of microglia cells. © 2012 Jonas et al.en_HK
dc.languageengen_US
dc.publisherPublic Library of Science. The Journal's web site is located at http://www.plosone.org/home.actionen_HK
dc.relation.ispartofPLoS ONEen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleThe spider effect: Morphological and orienting classification of microglia in response to stimuli in vivoen_HK
dc.typeArticleen_HK
dc.identifier.emailLiang, YX: yxliang@hkucc.hku.hken_HK
dc.identifier.emailTay, DKC: dkctay@hkucc.hku.hken_HK
dc.identifier.emailEllisBehnke, RG: rutledg@mit.eduen_HK
dc.identifier.authorityLiang, YX=rp00510en_HK
dc.identifier.authorityTay, DKC=rp00336en_HK
dc.identifier.authorityEllisBehnke, RG=rp00252en_HK
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.1371/journal.pone.0030763en_HK
dc.identifier.scopuseid_2-s2.0-84857406614en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84857406614&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume7en_HK
dc.identifier.issue2en_HK
dc.identifier.isiWOS:000302873700011-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridJonas, RA=37070534100en_HK
dc.identifier.scopusauthoridYuan, TF=23494329600en_HK
dc.identifier.scopusauthoridLiang, YX=55479398500en_HK
dc.identifier.scopusauthoridJonas, JB=7202492953en_HK
dc.identifier.scopusauthoridTay, DKC=55392935900en_HK
dc.identifier.scopusauthoridEllisBehnke, RG=8548055200en_HK

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