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Article: Garlic-derived S-allylmercaptocysteine is a hepato-protective agent in non-alcoholic fatty liver disease in vivo animal model

TitleGarlic-derived S-allylmercaptocysteine is a hepato-protective agent in non-alcoholic fatty liver disease in vivo animal model
Authors
KeywordsFibrosis
Inflammation
NAFLD
Oxidative stress
S-allylmercaptocysteine
Issue Date2013
PublisherDr Dietrich Steinkopff Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00394/index.htm
Citation
European Journal Of Nutrition, 2013, v. 52 n. 1, p. 179-191 How to Cite?
AbstractPurpose: To investigate the hepato-protective properties and underlying mechanisms of SAMC in a non-alcoholic fatty liver disease (NAFLD) rat model. Methods: Female rats were fed with a diet comprising highly unsaturated fat diet (30% fish oil) for 8 weeks to develop NAFLD with or without an intraperitoneal injection of 200 mg/kg SAMC three times per week. After euthanasia, blood and liver samples of rats were collected for histological and biochemical analyses. Results: Co-treatment of SAMC attenuated NAFLD-induced liver injury, fat accumulation, collagen formation and free fatty acids (FFAs). At the molecular level, SAMC decreased the lipogenesis marker and restored the lipolysis marker. SAMC also reduced the expression levels of pro-fibrogenic factors and diminished liver oxidative stress partly through the inhibition in the activity of cytochrome P450 2E1-dependent pathway. NAFLD-induced inflammation was also partially mitigated by SAMC treatment via reduction in the pro-inflammatory mediators, chemokines and suppressor of cytokine signaling. The protective effect of SAMC is also shown partly through the restoration of altered phosphorylation status of FFAs-dependent MAP kinase pathways and diminished in the nuclear transcription factors (NF-κB and AP-1) activity during NAFLD development. Conclusions: SAMC is a novel hepato-protective agent against NAFLD caused by abnormal liver functions. Garlic or garlic derivatives could be considered as a potent food supplement in the prevention of fatty liver disease. © 2012 The Author(s).
Persistent Identifierhttp://hdl.handle.net/10722/149778
ISSN
2015 Impact Factor: 3.239
2015 SCImago Journal Rankings: 1.337
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorXiao, Jen_HK
dc.contributor.authorChing, YPen_HK
dc.contributor.authorLiong, ECen_HK
dc.contributor.authorNanji, AAen_HK
dc.contributor.authorFung, MLen_HK
dc.contributor.authorTipoe, GLen_HK
dc.date.accessioned2012-06-26T05:58:28Z-
dc.date.available2012-06-26T05:58:28Z-
dc.date.issued2013en_HK
dc.identifier.citationEuropean Journal Of Nutrition, 2013, v. 52 n. 1, p. 179-191en_HK
dc.identifier.issn1436-6207en_HK
dc.identifier.urihttp://hdl.handle.net/10722/149778-
dc.description.abstractPurpose: To investigate the hepato-protective properties and underlying mechanisms of SAMC in a non-alcoholic fatty liver disease (NAFLD) rat model. Methods: Female rats were fed with a diet comprising highly unsaturated fat diet (30% fish oil) for 8 weeks to develop NAFLD with or without an intraperitoneal injection of 200 mg/kg SAMC three times per week. After euthanasia, blood and liver samples of rats were collected for histological and biochemical analyses. Results: Co-treatment of SAMC attenuated NAFLD-induced liver injury, fat accumulation, collagen formation and free fatty acids (FFAs). At the molecular level, SAMC decreased the lipogenesis marker and restored the lipolysis marker. SAMC also reduced the expression levels of pro-fibrogenic factors and diminished liver oxidative stress partly through the inhibition in the activity of cytochrome P450 2E1-dependent pathway. NAFLD-induced inflammation was also partially mitigated by SAMC treatment via reduction in the pro-inflammatory mediators, chemokines and suppressor of cytokine signaling. The protective effect of SAMC is also shown partly through the restoration of altered phosphorylation status of FFAs-dependent MAP kinase pathways and diminished in the nuclear transcription factors (NF-κB and AP-1) activity during NAFLD development. Conclusions: SAMC is a novel hepato-protective agent against NAFLD caused by abnormal liver functions. Garlic or garlic derivatives could be considered as a potent food supplement in the prevention of fatty liver disease. © 2012 The Author(s).en_HK
dc.languageengen_US
dc.publisherDr Dietrich Steinkopff Verlag. The Journal's web site is located at http://link.springer.de/link/service/journals/00394/index.htmen_HK
dc.relation.ispartofEuropean Journal of Nutritionen_HK
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectFibrosisen_HK
dc.subjectInflammationen_HK
dc.subjectNAFLDen_HK
dc.subjectOxidative stressen_HK
dc.subjectS-allylmercaptocysteineen_HK
dc.titleGarlic-derived S-allylmercaptocysteine is a hepato-protective agent in non-alcoholic fatty liver disease in vivo animal modelen_HK
dc.typeArticleen_HK
dc.identifier.emailChing, YP: ypching@hku.hken_HK
dc.identifier.emailFung, ML: fungml@hkucc.hku.hken_HK
dc.identifier.emailTipoe, GL: tgeorge@hkucc.hku.hken_HK
dc.identifier.emailLiong, EC: eclionga@hkucc.hku.hk-
dc.identifier.authorityChing, YP=rp00469en_HK
dc.identifier.authorityFung, ML=rp00433en_HK
dc.identifier.authorityTipoe, GL=rp00371en_HK
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.1007/s00394-012-0301-0en_HK
dc.identifier.pmid22278044-
dc.identifier.scopuseid_2-s2.0-84872674658en_HK
dc.identifier.hkuros199908-
dc.identifier.hkuros223460-
dc.identifier.spage179en_HK
dc.identifier.epage191en_HK
dc.identifier.eissn1436-6215-
dc.identifier.isiWOS:000313812100018-
dc.publisher.placeGermanyen_HK
dc.identifier.scopusauthoridXiao, J=54909206800en_HK
dc.identifier.scopusauthoridChing, YP=7005431277en_HK
dc.identifier.scopusauthoridLiong, EC=6602732210en_HK
dc.identifier.scopusauthoridNanji, AA=35885060300en_HK
dc.identifier.scopusauthoridFung, ML=7101955092en_HK
dc.identifier.scopusauthoridTipoe, GL=7003550610en_HK
dc.identifier.citeulike10315851-

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