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Article: Elevated blood pressure aggravates intracerebral hemorrhage-induced brain injury

TitleElevated blood pressure aggravates intracerebral hemorrhage-induced brain injury
Authors
Keywordscell proliferation
functional deficits
hypertension
intracerebral hemorrhage
Issue Date2011
PublisherMary Ann Liebert, Inc Publishers. The Journal's web site is located at http://www.liebertpub.com/neu
Citation
Journal Of Neurotrauma, 2011, v. 28 n. 12, p. 2523-2534 How to Cite?
AbstractElevated blood pressure (BP) is commonly seen in patients with intracerebral hemorrhage (ICH), and is independently associated with poor functional outcomes. Little is known about how elevated BP influences ICH-related brain injury. In the present study, we investigated the physiological and brain histological changes, as well as functional recovery following ICH in renovascular hypertensive rats. Renovascular hypertension (RVHT) was achieved by applying a silver clip onto the left renal artery of adult Sprague-Dawley rats. ICH was induced by an intrastriatal injection of bacterial collagenase IV about 5-6 weeks after left renal artery clipping or the sham operation. Following induction of ICH, both the normotensive and RVHT rats demonstrated an ultra-acute elevation in BP. Elevated BP increased hematoma volume, brain swelling, and apoptosis in the perihematomal areas. Brain degeneration, including local atrophy and lateral ventricle enlargement, was greater in the RVHT rats. In addition, many proliferating cells were seen over the ipsilateral striatum in the RVHT rats after ICH. The modified limb placing tests were done weekly for 3 weeks. In line with the histological damage, elevated BP worsened neurological deficits. These results suggest that ICH in the hypertensive rats mimics the clinical scenario of hypertensive ICH and may provide a platform to study the mechanisms of ICH-induced brain injury and potential therapies for ICH. © 2011, Mary Ann Liebert, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/149774
ISSN
2015 Impact Factor: 4.377
2015 SCImago Journal Rankings: 1.945
PubMed Central ID
ISI Accession Number ID
Funding AgencyGrant Number
Research Grants CouncilHKU763109M
Committee on Research and Conference200707176018
200807176052
201007176091
Funding Information:

This work was supported by a General Research Fund of Research Grants Council (HKU763109M) and Committee on Research and Conference Grants (200707176018, 200807176052, 201007176091).

References

 

DC FieldValueLanguage
dc.contributor.authorSang, YHen_HK
dc.contributor.authorSu, HXen_HK
dc.contributor.authorWu, WTen_HK
dc.contributor.authorSo, KFen_HK
dc.contributor.authorCheung, RTFen_HK
dc.date.accessioned2012-06-26T05:58:25Z-
dc.date.available2012-06-26T05:58:25Z-
dc.date.issued2011en_HK
dc.identifier.citationJournal Of Neurotrauma, 2011, v. 28 n. 12, p. 2523-2534en_HK
dc.identifier.issn0897-7151en_HK
dc.identifier.urihttp://hdl.handle.net/10722/149774-
dc.description.abstractElevated blood pressure (BP) is commonly seen in patients with intracerebral hemorrhage (ICH), and is independently associated with poor functional outcomes. Little is known about how elevated BP influences ICH-related brain injury. In the present study, we investigated the physiological and brain histological changes, as well as functional recovery following ICH in renovascular hypertensive rats. Renovascular hypertension (RVHT) was achieved by applying a silver clip onto the left renal artery of adult Sprague-Dawley rats. ICH was induced by an intrastriatal injection of bacterial collagenase IV about 5-6 weeks after left renal artery clipping or the sham operation. Following induction of ICH, both the normotensive and RVHT rats demonstrated an ultra-acute elevation in BP. Elevated BP increased hematoma volume, brain swelling, and apoptosis in the perihematomal areas. Brain degeneration, including local atrophy and lateral ventricle enlargement, was greater in the RVHT rats. In addition, many proliferating cells were seen over the ipsilateral striatum in the RVHT rats after ICH. The modified limb placing tests were done weekly for 3 weeks. In line with the histological damage, elevated BP worsened neurological deficits. These results suggest that ICH in the hypertensive rats mimics the clinical scenario of hypertensive ICH and may provide a platform to study the mechanisms of ICH-induced brain injury and potential therapies for ICH. © 2011, Mary Ann Liebert, Inc.en_HK
dc.languageengen_US
dc.publisherMary Ann Liebert, Inc Publishers. The Journal's web site is located at http://www.liebertpub.com/neuen_HK
dc.relation.ispartofJournal of Neurotraumaen_HK
dc.rightsThis is a copy of an article published in the Journal of Neurotrauma © 2011 copyright Mary Ann Liebert, Inc.; Journal of Neurotrauma is available online at: http://www.liebertonline.com.-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subjectcell proliferationen_HK
dc.subjectfunctional deficitsen_HK
dc.subjecthypertensionen_HK
dc.subjectintracerebral hemorrhageen_HK
dc.titleElevated blood pressure aggravates intracerebral hemorrhage-induced brain injuryen_HK
dc.typeArticleen_HK
dc.identifier.emailSo, KF:hrmaskf@hkucc.hku.hken_HK
dc.identifier.emailCheung, RTF:rtcheung@hku.hken_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.identifier.authorityCheung, RTF=rp00434en_HK
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.1089/neu.2010.1680en_HK
dc.identifier.pmid21988112-
dc.identifier.pmcidPMC3235342-
dc.identifier.scopuseid_2-s2.0-83455201126en_HK
dc.identifier.hkuros202188-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-83455201126&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume28en_HK
dc.identifier.issue12en_HK
dc.identifier.spage2523en_HK
dc.identifier.epage2534en_HK
dc.identifier.eissn1557-9042-
dc.identifier.isiWOS:000298291600012-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridSang, YH=54685193800en_HK
dc.identifier.scopusauthoridSu, HX=16317750200en_HK
dc.identifier.scopusauthoridWu, WT=54685469200en_HK
dc.identifier.scopusauthoridSo, KF=34668391300en_HK
dc.identifier.scopusauthoridCheung, RTF=7202397498en_HK
dc.customcontrol.immutablejt 130313-

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