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Article: The expression patterns of nogo-A, myelin associated glycoprotein and oligodendrocyte myelin glycoprotein in the retina after ocular hypertension : the expression of myelin proteins in the retina in glaucoma

TitleThe expression patterns of nogo-A, myelin associated glycoprotein and oligodendrocyte myelin glycoprotein in the retina after ocular hypertension : the expression of myelin proteins in the retina in glaucoma
Authors
Issue Date2011
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0364-3190
Citation
Neurochemical Research, 2011, v. 36 n. 11, p. 1955-1961 How to Cite?
AbstractNogo-A, a major myelin inhibitory protein, inhibits axon growth and synaptic function in the central nervous system. Glaucoma is a progressive neuropathy as a result of retinal ganglion cell (RGC) death. Synaptic degeneration is thought to be an early pathology of neurodegeneration in glaucoma and precedes RGC loss. Here experimental ocular hypertension model was induced in adult rats with laser coagulation of the episcleral and limbal veins. The expression of Nogo-A, myelin-associated glycoprotein (MAG) and oligodendrocyte myelin glycoprotein (OMgp) in the retina was investigated using immunohistochemistry and Western blotting. We found that Nogo-A was expressed in the RGCs and upregulated after the induction of ocular hypertension. OMgp was only expressed in the inner plexiform layer. There was no MAG expression in the retina. Our data provided, for the first time, the expression patterns of three myelin proteins in the adult retina and suggested an important role of Nogo-A in the RGC death and synaptic degeneration in glaucoma. © 2011 Springer Science+Business Media, LLC.
Persistent Identifierhttp://hdl.handle.net/10722/149771
ISSN
2015 Impact Factor: 2.472
2015 SCImago Journal Rankings: 1.102
ISI Accession Number ID
Funding AgencyGrant Number
University of Hong Kong
NSFC30801272
81071030
Science and Technology Foundation of Guangdong Province, China2008B030301090
2010B031600089
RFDP200805581160
Fundamental Research Funds for the Central Universities09ykpy25
09ykpy31
National Basic Research Program of China (973 Program)2011CB707501
Funding Information:

This study was supported by funding from the Jessie Ho Professorship in Neurosciences from the University of Hong Kong, NSFC (30801272, 81071030), Science and Technology Foundation of Guangdong Province, China (2008B030301090, 2010B031600089), RFDP (200805581160), the Fundamental Research Funds for the Central Universities (09ykpy25, 09ykpy31) and National Basic Research Program of China (973 Program) (2011CB707501).

References

 

DC FieldValueLanguage
dc.contributor.authorLiao, XXen_US
dc.contributor.authorChen, Den_US
dc.contributor.authorShi, Jen_US
dc.contributor.authorSun, YQen_US
dc.contributor.authorSun, SJen_US
dc.contributor.authorSo, KFen_US
dc.contributor.authorFu, QLen_US
dc.date.accessioned2012-06-26T05:58:20Z-
dc.date.available2012-06-26T05:58:20Z-
dc.date.issued2011en_US
dc.identifier.citationNeurochemical Research, 2011, v. 36 n. 11, p. 1955-1961en_US
dc.identifier.issn0364-3190en_US
dc.identifier.urihttp://hdl.handle.net/10722/149771-
dc.description.abstractNogo-A, a major myelin inhibitory protein, inhibits axon growth and synaptic function in the central nervous system. Glaucoma is a progressive neuropathy as a result of retinal ganglion cell (RGC) death. Synaptic degeneration is thought to be an early pathology of neurodegeneration in glaucoma and precedes RGC loss. Here experimental ocular hypertension model was induced in adult rats with laser coagulation of the episcleral and limbal veins. The expression of Nogo-A, myelin-associated glycoprotein (MAG) and oligodendrocyte myelin glycoprotein (OMgp) in the retina was investigated using immunohistochemistry and Western blotting. We found that Nogo-A was expressed in the RGCs and upregulated after the induction of ocular hypertension. OMgp was only expressed in the inner plexiform layer. There was no MAG expression in the retina. Our data provided, for the first time, the expression patterns of three myelin proteins in the adult retina and suggested an important role of Nogo-A in the RGC death and synaptic degeneration in glaucoma. © 2011 Springer Science+Business Media, LLC.en_US
dc.languageengen_US
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0364-3190en_US
dc.relation.ispartofNeurochemical Researchen_US
dc.rightsThe original publication is available at www.springerlink.com-
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshAnimalsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGlaucoma - Metabolismen_US
dc.subject.meshMyelin Proteins - Biosynthesisen_US
dc.subject.meshMyelin-Associated Glycoprotein - Biosynthesisen_US
dc.subject.meshOcular Hypertension - Metabolismen_US
dc.subject.meshRatsen_US
dc.subject.meshRetina - Metabolismen_US
dc.subject.meshRetinal Ganglion Cells - Metabolismen_US
dc.subject.meshUp-Regulationen_US
dc.titleThe expression patterns of nogo-A, myelin associated glycoprotein and oligodendrocyte myelin glycoprotein in the retina after ocular hypertension : the expression of myelin proteins in the retina in glaucomaen_US
dc.typeArticleen_US
dc.identifier.emailSo, KF:hrmaskf@hkucc.hku.hken_US
dc.identifier.authoritySo, KF=rp00329en_US
dc.description.naturepostprinten_US
dc.identifier.doi10.1007/s11064-011-0518-yen_US
dc.identifier.pmid21643729-
dc.identifier.scopuseid_2-s2.0-80055007003en_US
dc.identifier.hkuros192208-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-80055007003&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume36en_US
dc.identifier.issue11en_US
dc.identifier.spage1955en_US
dc.identifier.epage1961en_US
dc.identifier.isiWOS:000296523800002-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLiao, XX=54398828500en_US
dc.identifier.scopusauthoridChen, D=7405450361en_US
dc.identifier.scopusauthoridShi, J=26025986700en_US
dc.identifier.scopusauthoridSun, YQ=54399260000en_US
dc.identifier.scopusauthoridSun, SJ=54399333500en_US
dc.identifier.scopusauthoridSo, KF=34668391300en_US
dc.identifier.scopusauthoridFu, QL=23388762000en_US
dc.identifier.citeulike9405851-

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