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Article: S-allylmercaptocysteine effectively inhibits the proliferation of colorectal cancer cells under in vitro and in vivo conditions

TitleS-allylmercaptocysteine effectively inhibits the proliferation of colorectal cancer cells under in vitro and in vivo conditions
Authors
Issue Date2011
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet
Citation
Cancer Letters, 2011, v. 310 n. 1, p. 69-76 How to Cite?
AbstractS-allylmercaptocysteine (SAMC), one of the water-soluble organosulfur garlic derivatives, has been demonstrated as a suppressive agent against some tumors. The effects of SAMC on the proliferation and metastasis of colorectal cancer (CRC) under in vitro and in vivo conditions were evaluated here. The viabilities and migrations of CRC cells SW480, SW620, Caco-2 treated with SAMC were measured by MTT, scratch-wound, and transwell assays. The in vivo anticancer effect of SAMC against luciferase-expressing SW620 xenografts in mice was determined by bioluminescence imaging and histopathology observation. The apoptosis of SAMC-treated CRC cells was examined by Western blotting. The results demonstrate that SAMC could effectively suppress the growth and metastasis of colorectal cancer cells both in vivo and in vitro. The anticancer effect of SAMC was related to the decreased proliferation and increased apoptosis as well as necrosis of cancer cells. Oral administration of SAMC in the quantity/concentration used had no apparent toxic side effect on the vital organs of the experimental mice. Taken together, the proliferation and metastasis of CRC cells can be significantly suppressed by SAMC treatment under both in vitro and in vivo conditions. SAMC may thus be a promising candidate for CRC chemotherapy. © 2011 Elsevier Ireland Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/149767
ISSN
2014 Impact Factor: 5.621
ISI Accession Number ID
Funding AgencyGrant Number
Natural Science Foundation of China30872231
Funding Information:

This work was partly supported by grant from Natural Science Foundation of China (No. 30872231) to Prof. Zhaohua Zhong. We thank Wakunaga Pharmaceutical, Hiroshima, Japan, for the gift of garlic-derived compound SAMC to Prof. Yong-Chuan Wong, University of Hong Kong.

References

 

DC FieldValueLanguage
dc.contributor.authorLiang, Den_US
dc.contributor.authorQin, Yen_US
dc.contributor.authorZhao, Wen_US
dc.contributor.authorZhai, Xen_US
dc.contributor.authorGuo, Zen_US
dc.contributor.authorWang, Ren_US
dc.contributor.authorTong, Len_US
dc.contributor.authorLin, Len_US
dc.contributor.authorChen, Hen_US
dc.contributor.authorWong, YCen_US
dc.contributor.authorZhong, Zen_US
dc.date.accessioned2012-06-26T05:58:17Z-
dc.date.available2012-06-26T05:58:17Z-
dc.date.issued2011en_US
dc.identifier.citationCancer Letters, 2011, v. 310 n. 1, p. 69-76en_US
dc.identifier.issn0304-3835en_US
dc.identifier.urihttp://hdl.handle.net/10722/149767-
dc.description.abstractS-allylmercaptocysteine (SAMC), one of the water-soluble organosulfur garlic derivatives, has been demonstrated as a suppressive agent against some tumors. The effects of SAMC on the proliferation and metastasis of colorectal cancer (CRC) under in vitro and in vivo conditions were evaluated here. The viabilities and migrations of CRC cells SW480, SW620, Caco-2 treated with SAMC were measured by MTT, scratch-wound, and transwell assays. The in vivo anticancer effect of SAMC against luciferase-expressing SW620 xenografts in mice was determined by bioluminescence imaging and histopathology observation. The apoptosis of SAMC-treated CRC cells was examined by Western blotting. The results demonstrate that SAMC could effectively suppress the growth and metastasis of colorectal cancer cells both in vivo and in vitro. The anticancer effect of SAMC was related to the decreased proliferation and increased apoptosis as well as necrosis of cancer cells. Oral administration of SAMC in the quantity/concentration used had no apparent toxic side effect on the vital organs of the experimental mice. Taken together, the proliferation and metastasis of CRC cells can be significantly suppressed by SAMC treatment under both in vitro and in vivo conditions. SAMC may thus be a promising candidate for CRC chemotherapy. © 2011 Elsevier Ireland Ltd.en_US
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canleten_US
dc.relation.ispartofCancer Lettersen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntineoplastic Agents, Phytogenic - Pharmacologyen_US
dc.subject.meshApoptosis - Drug Effectsen_US
dc.subject.meshBlotting, Westernen_US
dc.subject.meshCaco-2 Cellsen_US
dc.subject.meshCaspase 3 - Metabolismen_US
dc.subject.meshCell Line, Tumoren_US
dc.subject.meshCell Proliferation - Drug Effectsen_US
dc.subject.meshCell Survival - Drug Effectsen_US
dc.subject.meshColorectal Neoplasms - Drug Therapy - Metabolism - Pathologyen_US
dc.subject.meshCysteine - Analogs & Derivatives - Pharmacologyen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshEnzyme Activation - Drug Effectsen_US
dc.subject.meshHumansen_US
dc.subject.meshLuciferases, Firefly - Genetics - Metabolismen_US
dc.subject.meshMaleen_US
dc.subject.meshMiceen_US
dc.subject.meshPoly(Adp-Ribose) Polymerases - Metabolismen_US
dc.subject.meshTime Factorsen_US
dc.subject.meshXenograft Model Antitumor Assaysen_US
dc.titleS-allylmercaptocysteine effectively inhibits the proliferation of colorectal cancer cells under in vitro and in vivo conditionsen_US
dc.typeArticleen_US
dc.identifier.emailWong, YC:ycwong@hkucc.hku.hken_US
dc.identifier.authorityWong, YC=rp00316en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.canlet.2011.06.019en_US
dc.identifier.pmid21794975-
dc.identifier.scopuseid_2-s2.0-79961129315en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79961129315&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume310en_US
dc.identifier.issue1en_US
dc.identifier.spage69en_US
dc.identifier.epage76en_US
dc.identifier.isiWOS:000294982300009-
dc.publisher.placeIrelanden_US
dc.identifier.scopusauthoridLiang, D=54380447600en_US
dc.identifier.scopusauthoridQin, Y=54380578100en_US
dc.identifier.scopusauthoridZhao, W=24333403200en_US
dc.identifier.scopusauthoridZhai, X=54381100600en_US
dc.identifier.scopusauthoridGuo, Z=54379972100en_US
dc.identifier.scopusauthoridWang, R=54380943700en_US
dc.identifier.scopusauthoridTong, L=35485996800en_US
dc.identifier.scopusauthoridLin, L=24331792000en_US
dc.identifier.scopusauthoridChen, H=18133280700en_US
dc.identifier.scopusauthoridWong, YC=7403041798en_US
dc.identifier.scopusauthoridZhong, Z=45761550300en_US
dc.identifier.citeulike9651712-

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