Article: S-allylmercaptocysteine effectively inhibits the proliferation of colorectal cancer cells under in vitro and in vivo conditions

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TitleS-allylmercaptocysteine effectively inhibits the proliferation of colorectal cancer cells under in vitro and in vivo conditions
AuthorsLiang, D1
Qin, Y1
Zhao, W1
Zhai, X1
Guo, Z1
Wang, R1
Tong, L1
Lin, L1
Chen, H1
Wong, YC1 2 3
Zhong, Z1
Issue Date2011
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet
CitationCancer Letters, 2011, v. 310 n. 1, p. 69-76 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.canlet.2011.06.019
AbstractS-allylmercaptocysteine (SAMC), one of the water-soluble organosulfur garlic derivatives, has been demonstrated as a suppressive agent against some tumors. The effects of SAMC on the proliferation and metastasis of colorectal cancer (CRC) under in vitro and in vivo conditions were evaluated here. The viabilities and migrations of CRC cells SW480, SW620, Caco-2 treated with SAMC were measured by MTT, scratch-wound, and transwell assays. The in vivo anticancer effect of SAMC against luciferase-expressing SW620 xenografts in mice was determined by bioluminescence imaging and histopathology observation. The apoptosis of SAMC-treated CRC cells was examined by Western blotting. The results demonstrate that SAMC could effectively suppress the growth and metastasis of colorectal cancer cells both in vivo and in vitro. The anticancer effect of SAMC was related to the decreased proliferation and increased apoptosis as well as necrosis of cancer cells. Oral administration of SAMC in the quantity/concentration used had no apparent toxic side effect on the vital organs of the experimental mice. Taken together, the proliferation and metastasis of CRC cells can be significantly suppressed by SAMC treatment under both in vitro and in vivo conditions. SAMC may thus be a promising candidate for CRC chemotherapy. © 2011 Elsevier Ireland Ltd.
ISSN0304-3835
2011 Impact Factor: 4.238
2011 SCImago Journal Rankings: 0.494
DOIhttp://dx.doi.org/10.1016/j.canlet.2011.06.019
ISI Accession Number IDWOS:000294982300009
Funding AgencyGrant Number
Natural Science Foundation of China30872231
Funding Information:

This work was partly supported by grant from Natural Science Foundation of China (No. 30872231) to Prof. Zhaohua Zhong. We thank Wakunaga Pharmaceutical, Hiroshima, Japan, for the gift of garlic-derived compound SAMC to Prof. Yong-Chuan Wong, University of Hong Kong.

ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorLiang, D
dc.contributor.authorQin, Y
dc.contributor.authorZhao, W
dc.contributor.authorZhai, X
dc.contributor.authorGuo, Z
dc.contributor.authorWang, R
dc.contributor.authorTong, L
dc.contributor.authorLin, L
dc.contributor.authorChen, H
dc.contributor.authorWong, YC
dc.contributor.authorZhong, Z
dc.date.accessioned2012-06-26T05:58:17Z
dc.date.available2012-06-26T05:58:17Z
dc.date.issued2011
dc.description.abstractS-allylmercaptocysteine (SAMC), one of the water-soluble organosulfur garlic derivatives, has been demonstrated as a suppressive agent against some tumors. The effects of SAMC on the proliferation and metastasis of colorectal cancer (CRC) under in vitro and in vivo conditions were evaluated here. The viabilities and migrations of CRC cells SW480, SW620, Caco-2 treated with SAMC were measured by MTT, scratch-wound, and transwell assays. The in vivo anticancer effect of SAMC against luciferase-expressing SW620 xenografts in mice was determined by bioluminescence imaging and histopathology observation. The apoptosis of SAMC-treated CRC cells was examined by Western blotting. The results demonstrate that SAMC could effectively suppress the growth and metastasis of colorectal cancer cells both in vivo and in vitro. The anticancer effect of SAMC was related to the decreased proliferation and increased apoptosis as well as necrosis of cancer cells. Oral administration of SAMC in the quantity/concentration used had no apparent toxic side effect on the vital organs of the experimental mice. Taken together, the proliferation and metastasis of CRC cells can be significantly suppressed by SAMC treatment under both in vitro and in vivo conditions. SAMC may thus be a promising candidate for CRC chemotherapy. © 2011 Elsevier Ireland Ltd.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationCancer Letters, 2011, v. 310 n. 1, p. 69-76 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.canlet.2011.06.019
dc.identifier.citeulike9651712
dc.identifier.doihttp://dx.doi.org/10.1016/j.canlet.2011.06.019
dc.identifier.epage76
dc.identifier.isiWOS:000294982300009
Funding AgencyGrant Number
Natural Science Foundation of China30872231
Funding Information:

This work was partly supported by grant from Natural Science Foundation of China (No. 30872231) to Prof. Zhaohua Zhong. We thank Wakunaga Pharmaceutical, Hiroshima, Japan, for the gift of garlic-derived compound SAMC to Prof. Yong-Chuan Wong, University of Hong Kong.

dc.identifier.issn0304-3835
2011 Impact Factor: 4.238
2011 SCImago Journal Rankings: 0.494
dc.identifier.issue1
dc.identifier.pmid21794975
dc.identifier.scopuseid_2-s2.0-79961129315
dc.identifier.spage69
dc.identifier.urihttp://hdl.handle.net/10722/149767
dc.identifier.volume310
dc.languageeng
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet
dc.publisher.placeIreland
dc.relation.ispartofCancer Letters
dc.relation.referencesReferences in Scopus
dc.subject.meshAnimals
dc.subject.meshAntineoplastic Agents, Phytogenic - Pharmacology
dc.subject.meshApoptosis - Drug Effects
dc.subject.meshBlotting, Western
dc.subject.meshCaco-2 Cells
dc.subject.meshCaspase 3 - Metabolism
dc.subject.meshCell Line, Tumor
dc.subject.meshCell Proliferation - Drug Effects
dc.subject.meshCell Survival - Drug Effects
dc.subject.meshColorectal Neoplasms - Drug Therapy - Metabolism - Pathology
dc.subject.meshCysteine - Analogs & Derivatives - Pharmacology
dc.subject.meshDose-Response Relationship, Drug
dc.subject.meshEnzyme Activation - Drug Effects
dc.subject.meshHumans
dc.subject.meshLuciferases, Firefly - Genetics - Metabolism
dc.subject.meshMale
dc.subject.meshMice
dc.subject.meshPoly(Adp-Ribose) Polymerases - Metabolism
dc.subject.meshTime Factors
dc.subject.meshXenograft Model Antitumor Assays
dc.titleS-allylmercaptocysteine effectively inhibits the proliferation of colorectal cancer cells under in vitro and in vivo conditions
dc.typeArticle
Author Affiliations
  1. Harbin Medical University
  2. The University of Hong Kong
  3. Davos Life Science Pte Ltd