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Article: S-allylmercaptocysteine effectively inhibits the proliferation of colorectal cancer cells under in vitro and in vivo conditions
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TitleS-allylmercaptocysteine effectively inhibits the proliferation of colorectal cancer cells under in vitro and in vivo conditions
 
AuthorsLiang, D1
Qin, Y1
Zhao, W1
Zhai, X1
Guo, Z1
Wang, R1
Tong, L1
Lin, L1
Chen, H1
Wong, YC3 1 2
Zhong, Z1
 
Issue Date2011
 
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet
 
CitationCancer Letters, 2011, v. 310 n. 1, p. 69-76 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.canlet.2011.06.019
 
AbstractS-allylmercaptocysteine (SAMC), one of the water-soluble organosulfur garlic derivatives, has been demonstrated as a suppressive agent against some tumors. The effects of SAMC on the proliferation and metastasis of colorectal cancer (CRC) under in vitro and in vivo conditions were evaluated here. The viabilities and migrations of CRC cells SW480, SW620, Caco-2 treated with SAMC were measured by MTT, scratch-wound, and transwell assays. The in vivo anticancer effect of SAMC against luciferase-expressing SW620 xenografts in mice was determined by bioluminescence imaging and histopathology observation. The apoptosis of SAMC-treated CRC cells was examined by Western blotting. The results demonstrate that SAMC could effectively suppress the growth and metastasis of colorectal cancer cells both in vivo and in vitro. The anticancer effect of SAMC was related to the decreased proliferation and increased apoptosis as well as necrosis of cancer cells. Oral administration of SAMC in the quantity/concentration used had no apparent toxic side effect on the vital organs of the experimental mice. Taken together, the proliferation and metastasis of CRC cells can be significantly suppressed by SAMC treatment under both in vitro and in vivo conditions. SAMC may thus be a promising candidate for CRC chemotherapy. © 2011 Elsevier Ireland Ltd.
 
ISSN0304-3835
2013 Impact Factor: 5.016
 
DOIhttp://dx.doi.org/10.1016/j.canlet.2011.06.019
 
ISI Accession Number IDWOS:000294982300009
Funding AgencyGrant Number
Natural Science Foundation of China30872231
Funding Information:

This work was partly supported by grant from Natural Science Foundation of China (No. 30872231) to Prof. Zhaohua Zhong. We thank Wakunaga Pharmaceutical, Hiroshima, Japan, for the gift of garlic-derived compound SAMC to Prof. Yong-Chuan Wong, University of Hong Kong.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorLiang, D
 
dc.contributor.authorQin, Y
 
dc.contributor.authorZhao, W
 
dc.contributor.authorZhai, X
 
dc.contributor.authorGuo, Z
 
dc.contributor.authorWang, R
 
dc.contributor.authorTong, L
 
dc.contributor.authorLin, L
 
dc.contributor.authorChen, H
 
dc.contributor.authorWong, YC
 
dc.contributor.authorZhong, Z
 
dc.date.accessioned2012-06-26T05:58:17Z
 
dc.date.available2012-06-26T05:58:17Z
 
dc.date.issued2011
 
dc.description.abstractS-allylmercaptocysteine (SAMC), one of the water-soluble organosulfur garlic derivatives, has been demonstrated as a suppressive agent against some tumors. The effects of SAMC on the proliferation and metastasis of colorectal cancer (CRC) under in vitro and in vivo conditions were evaluated here. The viabilities and migrations of CRC cells SW480, SW620, Caco-2 treated with SAMC were measured by MTT, scratch-wound, and transwell assays. The in vivo anticancer effect of SAMC against luciferase-expressing SW620 xenografts in mice was determined by bioluminescence imaging and histopathology observation. The apoptosis of SAMC-treated CRC cells was examined by Western blotting. The results demonstrate that SAMC could effectively suppress the growth and metastasis of colorectal cancer cells both in vivo and in vitro. The anticancer effect of SAMC was related to the decreased proliferation and increased apoptosis as well as necrosis of cancer cells. Oral administration of SAMC in the quantity/concentration used had no apparent toxic side effect on the vital organs of the experimental mice. Taken together, the proliferation and metastasis of CRC cells can be significantly suppressed by SAMC treatment under both in vitro and in vivo conditions. SAMC may thus be a promising candidate for CRC chemotherapy. © 2011 Elsevier Ireland Ltd.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationCancer Letters, 2011, v. 310 n. 1, p. 69-76 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.canlet.2011.06.019
 
dc.identifier.citeulike9651712
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.canlet.2011.06.019
 
dc.identifier.epage76
 
dc.identifier.isiWOS:000294982300009
Funding AgencyGrant Number
Natural Science Foundation of China30872231
Funding Information:

This work was partly supported by grant from Natural Science Foundation of China (No. 30872231) to Prof. Zhaohua Zhong. We thank Wakunaga Pharmaceutical, Hiroshima, Japan, for the gift of garlic-derived compound SAMC to Prof. Yong-Chuan Wong, University of Hong Kong.

 
dc.identifier.issn0304-3835
2013 Impact Factor: 5.016
 
dc.identifier.issue1
 
dc.identifier.pmid21794975
 
dc.identifier.scopuseid_2-s2.0-79961129315
 
dc.identifier.spage69
 
dc.identifier.urihttp://hdl.handle.net/10722/149767
 
dc.identifier.volume310
 
dc.languageeng
 
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet
 
dc.publisher.placeIreland
 
dc.relation.ispartofCancer Letters
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAnimals
 
dc.subject.meshAntineoplastic Agents, Phytogenic - Pharmacology
 
dc.subject.meshApoptosis - Drug Effects
 
dc.subject.meshBlotting, Western
 
dc.subject.meshCaco-2 Cells
 
dc.subject.meshCaspase 3 - Metabolism
 
dc.subject.meshCell Line, Tumor
 
dc.subject.meshCell Proliferation - Drug Effects
 
dc.subject.meshCell Survival - Drug Effects
 
dc.subject.meshColorectal Neoplasms - Drug Therapy - Metabolism - Pathology
 
dc.subject.meshCysteine - Analogs & Derivatives - Pharmacology
 
dc.subject.meshDose-Response Relationship, Drug
 
dc.subject.meshEnzyme Activation - Drug Effects
 
dc.subject.meshHumans
 
dc.subject.meshLuciferases, Firefly - Genetics - Metabolism
 
dc.subject.meshMale
 
dc.subject.meshMice
 
dc.subject.meshPoly(Adp-Ribose) Polymerases - Metabolism
 
dc.subject.meshTime Factors
 
dc.subject.meshXenograft Model Antitumor Assays
 
dc.titleS-allylmercaptocysteine effectively inhibits the proliferation of colorectal cancer cells under in vitro and in vivo conditions
 
dc.typeArticle
 
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Author Affiliations
  1. Harbin Medical University
  2. The University of Hong Kong
  3. Davos Life Science Pte Ltd