File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: CNS regeneration after chronic injury using a self-assembled nanomaterial and MEMRI for real-time in vivo monitoring

TitleCNS regeneration after chronic injury using a self-assembled nanomaterial and MEMRI for real-time in vivo monitoring
Authors
KeywordsChronic CNS regeneration
In vivo
MEMRI
Nano contrast agent
Self-assembled materials
Issue Date2011
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/nanomed
Citation
Nanomedicine: Nanotechnology, Biology, And Medicine, 2011, v. 7 n. 3, p. 351-359 How to Cite?
AbstractTo speed up the process of central nervous system (CNS) recovery after injury, the need for real-time measurement of axon regeneration in vivo is essential to assess the extent of injury, as well as the optimal timing and delivery of therapeutics and rehabilitation. It was necessary to develop a chronic animal model with an in vivo measurement technique to provide a real-time monitoring and feedback system. Using the framework of the 4 P's of CNS regeneration (Preserve, Permit, Promote and Plasticity) as a guide, combined with noninvasive manganese-enhanced magnetic resonance imaging (MEMRI), we show a successful chronic injury model to measure CNS regeneration, combined with an in vivo measurement system to provide real-time feedback during every stage of the regeneration process. We also show that a chronic optic tract (OT) lesion is able to heal, and axons are able to regenerate, when treated with a self-assembling nanofiber peptide scaffold (SAPNS). © 2011 Elsevier Inc.
Persistent Identifierhttp://hdl.handle.net/10722/149764
ISSN
2015 Impact Factor: 5.671
2015 SCImago Journal Rankings: 1.886
ISI Accession Number ID
Funding AgencyGrant Number
University of Hong Kong
Funding Information:

Research support from University of Hong Kong Seed Funding Programme for Applied Research.

References

 

DC FieldValueLanguage
dc.contributor.authorLiang, YXen_HK
dc.contributor.authorCheung, SWHen_HK
dc.contributor.authorChan, KCWen_HK
dc.contributor.authorWu, EXen_HK
dc.contributor.authorTay, DKCen_HK
dc.contributor.authorEllisBehnke, RGen_HK
dc.date.accessioned2012-06-26T05:58:12Z-
dc.date.available2012-06-26T05:58:12Z-
dc.date.issued2011en_HK
dc.identifier.citationNanomedicine: Nanotechnology, Biology, And Medicine, 2011, v. 7 n. 3, p. 351-359en_HK
dc.identifier.issn1549-9634en_HK
dc.identifier.urihttp://hdl.handle.net/10722/149764-
dc.description.abstractTo speed up the process of central nervous system (CNS) recovery after injury, the need for real-time measurement of axon regeneration in vivo is essential to assess the extent of injury, as well as the optimal timing and delivery of therapeutics and rehabilitation. It was necessary to develop a chronic animal model with an in vivo measurement technique to provide a real-time monitoring and feedback system. Using the framework of the 4 P's of CNS regeneration (Preserve, Permit, Promote and Plasticity) as a guide, combined with noninvasive manganese-enhanced magnetic resonance imaging (MEMRI), we show a successful chronic injury model to measure CNS regeneration, combined with an in vivo measurement system to provide real-time feedback during every stage of the regeneration process. We also show that a chronic optic tract (OT) lesion is able to heal, and axons are able to regenerate, when treated with a self-assembling nanofiber peptide scaffold (SAPNS). © 2011 Elsevier Inc.en_HK
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/nanomeden_HK
dc.relation.ispartofNanomedicine: Nanotechnology, Biology, and Medicineen_HK
dc.subjectChronic CNS regenerationen_HK
dc.subjectIn vivoen_HK
dc.subjectMEMRIen_HK
dc.subjectNano contrast agenten_HK
dc.subjectSelf-assembled materialsen_HK
dc.subject.meshAnimalsen_US
dc.subject.meshBehavior, Animalen_US
dc.subject.meshCentral Nervous System - Injuries - Physiopathologyen_US
dc.subject.meshChronic Diseaseen_US
dc.subject.meshContrast Media - Administration & Dosageen_US
dc.subject.meshCricetinaeen_US
dc.subject.meshMagnetic Resonance Imaging - Methodsen_US
dc.subject.meshManganese - Diagnostic Useen_US
dc.subject.meshNanofibers - Chemistry - Diagnostic Useen_US
dc.subject.meshNerve Regeneration - Physiologyen_US
dc.subject.meshOptic Nerve - Pathology - Surgeryen_US
dc.subject.meshPeptides - Chemistry - Diagnostic Useen_US
dc.subject.meshPilot Projectsen_US
dc.subject.meshRegenerative Medicine - Methodsen_US
dc.subject.meshReproducibility Of Resultsen_US
dc.subject.meshTime Factorsen_US
dc.subject.meshVisual Pathways - Pathology - Surgeryen_US
dc.titleCNS regeneration after chronic injury using a self-assembled nanomaterial and MEMRI for real-time in vivo monitoringen_HK
dc.typeArticleen_HK
dc.identifier.emailLiang, YX: yxliang@hkucc.hku.hken_HK
dc.identifier.emailCheung, SWH: sunnycwh@hku.hken_HK
dc.identifier.emailWu, EX: ewu1@hkucc.hku.hken_HK
dc.identifier.emailTay, DKC: dkctay@hkucc.hku.hken_HK
dc.identifier.emailEllisBehnke, RG: rutledg@mit.eduen_HK
dc.identifier.authorityLiang, YX=rp00510en_HK
dc.identifier.authorityCheung, SWH=rp00246en_HK
dc.identifier.authorityWu, EX=rp00193en_HK
dc.identifier.authorityTay, DKC=rp00336en_HK
dc.identifier.authorityEllisBehnke, RG=rp00252en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.nano.2010.12.001en_HK
dc.identifier.pmid21185404-
dc.identifier.scopuseid_2-s2.0-79956344169en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-79956344169&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume7en_HK
dc.identifier.issue3en_HK
dc.identifier.spage351en_HK
dc.identifier.epage359en_HK
dc.identifier.isiWOS:000291032800012-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridLiang, YX=55479398500en_HK
dc.identifier.scopusauthoridCheung, SWH=36152058800en_HK
dc.identifier.scopusauthoridChan, KCW=34968940300en_HK
dc.identifier.scopusauthoridWu, EX=7202128034en_HK
dc.identifier.scopusauthoridTay, DKC=55392935900en_HK
dc.identifier.scopusauthoridEllisBehnke, RG=8548055200en_HK

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats