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Article: Upregulated expression of GAP-43 mRNA and protein in anterior horn motoneurons of the spinal cord after brachial plexus injury

TitleUpregulated expression of GAP-43 mRNA and protein in anterior horn motoneurons of the spinal cord after brachial plexus injury
Authors
Issue Date2010
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/arcmed
Citation
Archives Of Medical Research, 2010, v. 41 n. 7, p. 513-518 How to Cite?
AbstractBackground and Aims: This study is concerned with the expressions of growth-associated protein-43 (GAP-43) mRNA and protein in the anterior horn of the spinal cord after brachial plexus injury. Methods: Animals were killed 1, 7, 14 days after injury and were divided into three injury groups: group 1, right C 7 ventral motor root avulsion; group 2, right C 7 ventral motor root avulsion and cut right C 5-T 1 dorsal sensitive roots; and group 3, right C 7 ventral motor root avulsion plus right hemisection between C 5 and C 6 segment of the spinal cord. The combined behavioral scores (CBS) 1, 7 and 14 days after surgery were used in behavioral testing. Expressions of both GAP-43 mRNA and protein were analyzed using QRT-PCR and immunohistochemistry 14 days after surgery. Results: Among the injury groups, rats in group 3 had the highest score and those in group 1, the lowest score. On day 14 after surgery, the expressions of GAP-43 mRNA and protein were evidently up-regulated compared to the control group, with the highest in group 3 and the lowest in group 1, showing significant differences among the three injury groups (p <0.01). Conclusions: Our study suggests that the expressions of GAP-43 mRNA and protein may be upregulated after brachial plexus injury, and GAP-43 protein is possibly associated with the axon regeneration and function reconstruction. © 2010 IMSS.
Persistent Identifierhttp://hdl.handle.net/10722/149754
ISSN
2015 Impact Factor: 2.219
2015 SCImago Journal Rankings: 0.984
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChen, LJen_US
dc.contributor.authorRen, YHen_US
dc.contributor.authorLiu, Len_US
dc.contributor.authorZhang, XQen_US
dc.contributor.authorZhao, Yen_US
dc.contributor.authorWu, WTen_US
dc.contributor.authorLi, Fen_US
dc.date.accessioned2012-06-26T05:58:06Z-
dc.date.available2012-06-26T05:58:06Z-
dc.date.issued2010en_US
dc.identifier.citationArchives Of Medical Research, 2010, v. 41 n. 7, p. 513-518en_US
dc.identifier.issn0188-4409en_US
dc.identifier.urihttp://hdl.handle.net/10722/149754-
dc.description.abstractBackground and Aims: This study is concerned with the expressions of growth-associated protein-43 (GAP-43) mRNA and protein in the anterior horn of the spinal cord after brachial plexus injury. Methods: Animals were killed 1, 7, 14 days after injury and were divided into three injury groups: group 1, right C 7 ventral motor root avulsion; group 2, right C 7 ventral motor root avulsion and cut right C 5-T 1 dorsal sensitive roots; and group 3, right C 7 ventral motor root avulsion plus right hemisection between C 5 and C 6 segment of the spinal cord. The combined behavioral scores (CBS) 1, 7 and 14 days after surgery were used in behavioral testing. Expressions of both GAP-43 mRNA and protein were analyzed using QRT-PCR and immunohistochemistry 14 days after surgery. Results: Among the injury groups, rats in group 3 had the highest score and those in group 1, the lowest score. On day 14 after surgery, the expressions of GAP-43 mRNA and protein were evidently up-regulated compared to the control group, with the highest in group 3 and the lowest in group 1, showing significant differences among the three injury groups (p <0.01). Conclusions: Our study suggests that the expressions of GAP-43 mRNA and protein may be upregulated after brachial plexus injury, and GAP-43 protein is possibly associated with the axon regeneration and function reconstruction. © 2010 IMSS.en_US
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/arcmeden_US
dc.relation.ispartofArchives of Medical Researchen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnterior Horn Cells - Cytology - Metabolismen_US
dc.subject.meshBehavior, Animalen_US
dc.subject.meshBrachial Plexus - Injuriesen_US
dc.subject.meshGap-43 Protein - Genetics - Metabolismen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshRandom Allocationen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshSpinal Cord - Cytology - Metabolismen_US
dc.subject.meshUp-Regulationen_US
dc.titleUpregulated expression of GAP-43 mRNA and protein in anterior horn motoneurons of the spinal cord after brachial plexus injuryen_US
dc.typeArticleen_US
dc.identifier.emailWu, WT:wtwu@hkucc.hku.hken_US
dc.identifier.authorityWu, WT=rp00419en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.arcmed.2010.10.005en_US
dc.identifier.pmid21167390-
dc.identifier.scopuseid_2-s2.0-78650131949en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-78650131949&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume41en_US
dc.identifier.issue7en_US
dc.identifier.spage513en_US
dc.identifier.epage518en_US
dc.identifier.isiWOS:000285948200004-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridChen, LJ=17433588900en_US
dc.identifier.scopusauthoridRen, YH=37077900300en_US
dc.identifier.scopusauthoridLiu, L=37077416600en_US
dc.identifier.scopusauthoridZhang, XQ=37078563600en_US
dc.identifier.scopusauthoridZhao, Y=37078447400en_US
dc.identifier.scopusauthoridWu, WT=7407081122en_US
dc.identifier.scopusauthoridLi, F=7406056863en_US
dc.identifier.citeulike8456370-

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