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Article: Co-expression of GAP-43 and nNOS in avulsed motoneurons and their potential role for motoneuron regeneration

TitleCo-expression of GAP-43 and nNOS in avulsed motoneurons and their potential role for motoneuron regeneration
Authors
Yuan, QHu, BChu, THSu, HZhang, WSo, KFLin, ZWu, W
KeywordsAxonal injury
Motoneuron
Nitric oxide synthase
Regeneration
Spinal cord
Issue Date2010
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yniox
Citation
Nitric Oxide - Biology And Chemistry, 2010, v. 23 n. 4, p. 258-263 How to Cite?
DOI: http://dx.doi.org/10.1016/j.niox.2010.07.006
AbstractNeuronal nitric oxide synthase (nNOS) is induced after axonal injury. The role of induced nNOS in injured neurons is not well established. In the present study, we investigated the co-expression of nNOS with GAP-43 in spinal motoneurons following axonal injury. The role of induced nNOS was discussed and evaluated. In normal rats, spinal motoneurons do not express nNOS or GAP-43. Following spinal root avulsion, expression of nNOS and GAP-43 were induced and colocalized in avulsed motoneurons. Reimplantation of avulsed roots resulted in a remarkable decrease of GAP-43- and nNOS-IR in the soma of the injured motoneurons. A number of GAP-43-IR regenerating motor axons were found in the reimplanted nerve. In contrast, the nNOS-IR was absent in reimplanted nerve. These results suggest that expression of GAP-43 in avulsed motoneurons is related to axonal regeneration whereas nNOS is not. © 2010 Elsevier Inc.
Persistent Identifierhttp://hdl.handle.net/10722/149750
ISSN
1089-8603
2023 Impact Factor: 3.2
2023 SCImago Journal Rankings: 0.749
ISI Accession Number ID
WOS:000283894500002
Funding AgencyGrant Number
HKU Spinal Cord Injury Foundation
University of Hong Kong
Hong Kong Research Grants Council (RGC)
Funding Information:

This study was supported by HKU Spinal Cord Injury Foundation and grants from the University of Hong Kong and Hong Kong Research Grants Council (RGC).

References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorYuan, Qen_US
dc.contributor.authorHu, Ben_US
dc.contributor.authorChu, THen_US
dc.contributor.authorSu, Hen_US
dc.contributor.authorZhang, Wen_US
dc.contributor.authorSo, KFen_US
dc.contributor.authorLin, Zen_US
dc.contributor.authorWu, Wen_US
dc.date.accessioned2012-06-26T05:58:00Z-
dc.date.available2012-06-26T05:58:00Z-
dc.date.issued2010en_US
dc.identifier.citationNitric Oxide - Biology And Chemistry, 2010, v. 23 n. 4, p. 258-263en_US
dc.identifier.issn1089-8603en_US
dc.identifier.urihttp://hdl.handle.net/10722/149750-
dc.description.abstractNeuronal nitric oxide synthase (nNOS) is induced after axonal injury. The role of induced nNOS in injured neurons is not well established. In the present study, we investigated the co-expression of nNOS with GAP-43 in spinal motoneurons following axonal injury. The role of induced nNOS was discussed and evaluated. In normal rats, spinal motoneurons do not express nNOS or GAP-43. Following spinal root avulsion, expression of nNOS and GAP-43 were induced and colocalized in avulsed motoneurons. Reimplantation of avulsed roots resulted in a remarkable decrease of GAP-43- and nNOS-IR in the soma of the injured motoneurons. A number of GAP-43-IR regenerating motor axons were found in the reimplanted nerve. In contrast, the nNOS-IR was absent in reimplanted nerve. These results suggest that expression of GAP-43 in avulsed motoneurons is related to axonal regeneration whereas nNOS is not. © 2010 Elsevier Inc.en_US
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynioxen_US
dc.relation.ispartofNitric Oxide - Biology and Chemistryen_US
dc.subjectAxonal injury-
dc.subjectMotoneuron-
dc.subjectNitric oxide synthase-
dc.subjectRegeneration-
dc.subjectSpinal cord-
dc.subject.meshAnimalsen_US
dc.subject.meshAxons - Metabolismen_US
dc.subject.meshDisease Models, Animalen_US
dc.subject.meshFemaleen_US
dc.subject.meshGap-43 Protein - Metabolismen_US
dc.subject.meshMotor Neurons - Enzymology - Metabolismen_US
dc.subject.meshNerve Regenerationen_US
dc.subject.meshNitric Oxide Synthase Type I - Metabolismen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.titleCo-expression of GAP-43 and nNOS in avulsed motoneurons and their potential role for motoneuron regenerationen_US
dc.typeArticleen_US
dc.identifier.emailSo, KF:hrmaskf@hkucc.hku.hken_US
dc.identifier.emailWu, W:wtwu@hkucc.hku.hken_US
dc.identifier.authoritySo, KF=rp00329en_US
dc.identifier.authorityWu, W=rp00419en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.niox.2010.07.006en_US
dc.identifier.pmid20667480-
dc.identifier.scopuseid_2-s2.0-77958153558en_US
dc.identifier.hkuros175293-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77958153558&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume23en_US
dc.identifier.issue4en_US
dc.identifier.spage258en_US
dc.identifier.epage263en_US
dc.identifier.isiWOS:000283894500002-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridYuan, Q=7202814773en_US
dc.identifier.scopusauthoridHu, B=35733928400en_US
dc.identifier.scopusauthoridChu, TH=14023966500en_US
dc.identifier.scopusauthoridSu, H=16317750200en_US
dc.identifier.scopusauthoridZhang, W=37039036200en_US
dc.identifier.scopusauthoridSo, KF=34668391300en_US
dc.identifier.scopusauthoridLin, Z=26433004200en_US
dc.identifier.scopusauthoridWu, W=7407081122en_US
dc.identifier.citeulike7587115-
dc.identifier.issnl1089-8603-

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