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Article: Co-expression of GAP-43 and nNOS in avulsed motoneurons and their potential role for motoneuron regeneration
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TitleCo-expression of GAP-43 and nNOS in avulsed motoneurons and their potential role for motoneuron regeneration
 
AuthorsYuan, Q1 3
Hu, B1
Chu, TH1
Su, H1
Zhang, W1
So, KF1 2
Lin, Z3
Wu, W1 2
 
Issue Date2010
 
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yniox
 
CitationNitric Oxide - Biology And Chemistry, 2010, v. 23 n. 4, p. 258-263 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.niox.2010.07.006
 
AbstractNeuronal nitric oxide synthase (nNOS) is induced after axonal injury. The role of induced nNOS in injured neurons is not well established. In the present study, we investigated the co-expression of nNOS with GAP-43 in spinal motoneurons following axonal injury. The role of induced nNOS was discussed and evaluated. In normal rats, spinal motoneurons do not express nNOS or GAP-43. Following spinal root avulsion, expression of nNOS and GAP-43 were induced and colocalized in avulsed motoneurons. Reimplantation of avulsed roots resulted in a remarkable decrease of GAP-43- and nNOS-IR in the soma of the injured motoneurons. A number of GAP-43-IR regenerating motor axons were found in the reimplanted nerve. In contrast, the nNOS-IR was absent in reimplanted nerve. These results suggest that expression of GAP-43 in avulsed motoneurons is related to axonal regeneration whereas nNOS is not. © 2010 Elsevier Inc.
 
ISSN1089-8603
2013 Impact Factor: 3.180
 
DOIhttp://dx.doi.org/10.1016/j.niox.2010.07.006
 
ISI Accession Number IDWOS:000283894500002
Funding AgencyGrant Number
HKU Spinal Cord Injury Foundation
University of Hong Kong
Hong Kong Research Grants Council (RGC)
Funding Information:

This study was supported by HKU Spinal Cord Injury Foundation and grants from the University of Hong Kong and Hong Kong Research Grants Council (RGC).

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorYuan, Q
 
dc.contributor.authorHu, B
 
dc.contributor.authorChu, TH
 
dc.contributor.authorSu, H
 
dc.contributor.authorZhang, W
 
dc.contributor.authorSo, KF
 
dc.contributor.authorLin, Z
 
dc.contributor.authorWu, W
 
dc.date.accessioned2012-06-26T05:58:00Z
 
dc.date.available2012-06-26T05:58:00Z
 
dc.date.issued2010
 
dc.description.abstractNeuronal nitric oxide synthase (nNOS) is induced after axonal injury. The role of induced nNOS in injured neurons is not well established. In the present study, we investigated the co-expression of nNOS with GAP-43 in spinal motoneurons following axonal injury. The role of induced nNOS was discussed and evaluated. In normal rats, spinal motoneurons do not express nNOS or GAP-43. Following spinal root avulsion, expression of nNOS and GAP-43 were induced and colocalized in avulsed motoneurons. Reimplantation of avulsed roots resulted in a remarkable decrease of GAP-43- and nNOS-IR in the soma of the injured motoneurons. A number of GAP-43-IR regenerating motor axons were found in the reimplanted nerve. In contrast, the nNOS-IR was absent in reimplanted nerve. These results suggest that expression of GAP-43 in avulsed motoneurons is related to axonal regeneration whereas nNOS is not. © 2010 Elsevier Inc.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationNitric Oxide - Biology And Chemistry, 2010, v. 23 n. 4, p. 258-263 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.niox.2010.07.006
 
dc.identifier.citeulike7587115
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.niox.2010.07.006
 
dc.identifier.epage263
 
dc.identifier.hkuros175293
 
dc.identifier.isiWOS:000283894500002
Funding AgencyGrant Number
HKU Spinal Cord Injury Foundation
University of Hong Kong
Hong Kong Research Grants Council (RGC)
Funding Information:

This study was supported by HKU Spinal Cord Injury Foundation and grants from the University of Hong Kong and Hong Kong Research Grants Council (RGC).

 
dc.identifier.issn1089-8603
2013 Impact Factor: 3.180
 
dc.identifier.issue4
 
dc.identifier.pmid20667480
 
dc.identifier.scopuseid_2-s2.0-77958153558
 
dc.identifier.spage258
 
dc.identifier.urihttp://hdl.handle.net/10722/149750
 
dc.identifier.volume23
 
dc.languageeng
 
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yniox
 
dc.publisher.placeUnited States
 
dc.relation.ispartofNitric Oxide - Biology and Chemistry
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAnimals
 
dc.subject.meshAxons - Metabolism
 
dc.subject.meshDisease Models, Animal
 
dc.subject.meshFemale
 
dc.subject.meshGap-43 Protein - Metabolism
 
dc.subject.meshMotor Neurons - Enzymology - Metabolism
 
dc.subject.meshNerve Regeneration
 
dc.subject.meshNitric Oxide Synthase Type I - Metabolism
 
dc.subject.meshRats
 
dc.subject.meshRats, Sprague-Dawley
 
dc.titleCo-expression of GAP-43 and nNOS in avulsed motoneurons and their potential role for motoneuron regeneration
 
dc.typeArticle
 
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<contributor.author>Lin, Z</contributor.author>
<contributor.author>Wu, W</contributor.author>
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Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. Jinan University
  3. Chinese University of Hong Kong