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Article: Human γδ T cells: A lymphoid lineage cell capable of professional phagocytosis

TitleHuman γδ T cells: A lymphoid lineage cell capable of professional phagocytosis
Authors
Issue Date2009
PublisherAmerican Association of Immunologists. The Journal's web site is located at http://www.jimmunol.org
Citation
Journal Of Immunology, 2009, v. 183 n. 9, p. 5622-5629 How to Cite?
AbstractProfessional phagocytosis in mammals is considered to be performed exclusively by myeloid cell types. In this study, we demonstrate, for the first time, that a mammalian lymphocyte subset can operate as a professional phagocyte. By using confocal microscopy, transmission electron microscopy, and functional Ag presentation assays, we find that freshly isolated human peripheral blood γδ T cells can phagocytose Escherichia coli and 1 μm synthetic beads via Ab opsonization and CD16 (FcγRIII), leading to Ag processing and presentation on MHC class II. In contrast, other CD16 + lymphocytes, i.e., CD16 +/CD56 + NK cells, were not capable of such functions. These findings of distinct myeloid characteristics in γδ T cells strongly support the suggestion that γδ T cells are evolutionarily ancient lymphocytes and have implications for our understanding of their role in transitional immunity and the control of infectious diseases and cancer. Copyright © 2009 by The American Association of Immunologists, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/149742
ISSN
2014 Impact Factor: 4.922
2014 SCImago Journal Rankings: 3.031
ISI Accession Number ID
Funding AgencyGrant Number
Jean Shanks Foundation
Funding Information:

This work was supported by the Jean Shanks Foundation.

References

 

DC FieldValueLanguage
dc.contributor.authorWu, Yen_US
dc.contributor.authorWu, Wen_US
dc.contributor.authorWong, WMen_US
dc.contributor.authorWard, Een_US
dc.contributor.authorThrasher, AJen_US
dc.contributor.authorGoldblatt, Den_US
dc.contributor.authorOsman, Men_US
dc.contributor.authorDigard, Pen_US
dc.contributor.authorCanaday, DHen_US
dc.contributor.authorGustafsson, Ken_US
dc.date.accessioned2012-06-26T05:57:53Z-
dc.date.available2012-06-26T05:57:53Z-
dc.date.issued2009en_US
dc.identifier.citationJournal Of Immunology, 2009, v. 183 n. 9, p. 5622-5629en_US
dc.identifier.issn0022-1767en_US
dc.identifier.urihttp://hdl.handle.net/10722/149742-
dc.description.abstractProfessional phagocytosis in mammals is considered to be performed exclusively by myeloid cell types. In this study, we demonstrate, for the first time, that a mammalian lymphocyte subset can operate as a professional phagocyte. By using confocal microscopy, transmission electron microscopy, and functional Ag presentation assays, we find that freshly isolated human peripheral blood γδ T cells can phagocytose Escherichia coli and 1 μm synthetic beads via Ab opsonization and CD16 (FcγRIII), leading to Ag processing and presentation on MHC class II. In contrast, other CD16 + lymphocytes, i.e., CD16 +/CD56 + NK cells, were not capable of such functions. These findings of distinct myeloid characteristics in γδ T cells strongly support the suggestion that γδ T cells are evolutionarily ancient lymphocytes and have implications for our understanding of their role in transitional immunity and the control of infectious diseases and cancer. Copyright © 2009 by The American Association of Immunologists, Inc.en_US
dc.languageengen_US
dc.publisherAmerican Association of Immunologists. The Journal's web site is located at http://www.jimmunol.orgen_US
dc.relation.ispartofJournal of Immunologyen_US
dc.subject.meshAmino Acid Sequenceen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntigen Presentation - Immunologyen_US
dc.subject.meshCell Lineen_US
dc.subject.meshCell Line, Transformeden_US
dc.subject.meshCell Line, Tumoren_US
dc.subject.meshCell Lineage - Immunologyen_US
dc.subject.meshCoculture Techniquesen_US
dc.subject.meshEscherichia Coli - Immunologyen_US
dc.subject.meshHla-A Antigens - Immunology - Metabolismen_US
dc.subject.meshHla-Drb1 Chainsen_US
dc.subject.meshHumansen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Transgenicen_US
dc.subject.meshMicrospheresen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshOpsonin Proteins - Metabolismen_US
dc.subject.meshPhagocytosis - Immunologyen_US
dc.subject.meshReceptors, Antigen, T-Cell, Gamma-Delta - Biosynthesis - Physiologyen_US
dc.subject.meshReceptors, Igg - Physiologyen_US
dc.subject.meshT-Lymphocyte Subsets - Immunology - Metabolism - Ultrastructureen_US
dc.subject.meshViral Matrix Proteins - Immunology - Metabolismen_US
dc.titleHuman γδ T cells: A lymphoid lineage cell capable of professional phagocytosisen_US
dc.typeArticleen_US
dc.identifier.emailWu, W:wtwu@hkucc.hku.hken_US
dc.identifier.authorityWu, W=rp00419en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.4049/jimmunol.0901772en_US
dc.identifier.pmid19843947en_US
dc.identifier.scopuseid_2-s2.0-77952704343en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77952704343&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume183en_US
dc.identifier.issue9en_US
dc.identifier.spage5622en_US
dc.identifier.epage5629en_US
dc.identifier.isiWOS:000271488500025-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridWu, Y=36130811800en_US
dc.identifier.scopusauthoridWu, W=7407081122en_US
dc.identifier.scopusauthoridWong, WM=7403972413en_US
dc.identifier.scopusauthoridWard, E=36060860700en_US
dc.identifier.scopusauthoridThrasher, AJ=7005085037en_US
dc.identifier.scopusauthoridGoldblatt, D=7102190212en_US
dc.identifier.scopusauthoridOsman, M=7201930374en_US
dc.identifier.scopusauthoridDigard, P=6701641095en_US
dc.identifier.scopusauthoridCanaday, DH=6701913563en_US
dc.identifier.scopusauthoridGustafsson, K=7005333544en_US

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