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Article: LINGO-1 negatively regulates TrkB phosphorylation after ocular hypertension
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TitleLINGO-1 negatively regulates TrkB phosphorylation after ocular hypertension
 
AuthorsFu, QL1 4
Hu, B1 3
Li, X4
Shao, Z2
Shi, JB4
Wu, W1 5
So, KF1 5
Mi, S2
 
Issue Date2010
 
PublisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/EJN
 
CitationEuropean Journal Of Neuroscience, 2010, v. 31 n. 6, p. 1091-1097 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1460-9568.2010.07127.x
 
AbstractThe antagonism of LINGO-1, a CNS-specific negative regulator of neuronal survival, was shown to promote short-term survival of retinal ganglion cell (RGC) in an ocular hypertension model. LINGO-1 antagonists, combined with brain-derived neurotrophic factor (BDNF), can increase the length of neuron survival through an unclear molecular mechanism. To determine the relationship between LINGO-1 and BDNF/TrkB receptor in neuronal protection, we show here that LINGO-1 forms a receptor complex with TrkB and negatively regulates its activation in the retina after ocular hypertension injury. LINGO-1 antagonist antibody 1A7 or soluble LINGO-1 (LINGO-1-Fc) treatment upregulates phospho-TrkB phosphorylation and leads to RGC survival after high intraocular pressure injury. This neuronal protective effect was blocked by anti-BDNF antibody. LINGO-1 antagonism therefore promotes RGC survival by regulating the BDNF and TrkB signaling pathway after ocular hypertension. © Federation of European Neuroscience Societies and Blackwell Publishing Ltd.
 
ISSN0953-816X
2013 Impact Factor: 3.669
 
DOIhttp://dx.doi.org/10.1111/j.1460-9568.2010.07127.x
 
ISI Accession Number IDWOS:000275674400011
Funding AgencyGrant Number
The University of Hong Kong Foundation for Educational Development and Research Limited
NSFC30801272
RFDP200805581160
Natural Science Foundation of Guangdong Province of China8451008901000852
Training Foundation for the Youth Scholars of Sun Yat-Sen University2009009
2009026
Science and Technology Foundation of Guangdong Province of China2006B36004010
2008B030301090
Chinese Academy of Sciences
Funding Information:

This study was supported by funding from the Jessie Ho Professorship in Neuroscience (The University of Hong Kong Foundation for Educational Development and Research Limited, and donation from Mr George Ho), and donations from Ms Tung Shai Yun and Ms Annie Tsao Wen Wei. This research is also supported by grants from the NSFC (30801272), RFDP (200805581160), Natural Science Foundation of Guangdong Province of China (8451008901000852), Training Foundation for the Youth Scholars of Sun Yat-Sen University (2009009, 2009026) and The Science and Technology Foundation of Guangdong Province of China (2006B36004010, 2008B030301090). Bai Ren Ji Hua provided a grant to B.H. (Chinese Academy of Sciences).

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorFu, QL
 
dc.contributor.authorHu, B
 
dc.contributor.authorLi, X
 
dc.contributor.authorShao, Z
 
dc.contributor.authorShi, JB
 
dc.contributor.authorWu, W
 
dc.contributor.authorSo, KF
 
dc.contributor.authorMi, S
 
dc.date.accessioned2012-06-26T05:57:49Z
 
dc.date.available2012-06-26T05:57:49Z
 
dc.date.issued2010
 
dc.description.abstractThe antagonism of LINGO-1, a CNS-specific negative regulator of neuronal survival, was shown to promote short-term survival of retinal ganglion cell (RGC) in an ocular hypertension model. LINGO-1 antagonists, combined with brain-derived neurotrophic factor (BDNF), can increase the length of neuron survival through an unclear molecular mechanism. To determine the relationship between LINGO-1 and BDNF/TrkB receptor in neuronal protection, we show here that LINGO-1 forms a receptor complex with TrkB and negatively regulates its activation in the retina after ocular hypertension injury. LINGO-1 antagonist antibody 1A7 or soluble LINGO-1 (LINGO-1-Fc) treatment upregulates phospho-TrkB phosphorylation and leads to RGC survival after high intraocular pressure injury. This neuronal protective effect was blocked by anti-BDNF antibody. LINGO-1 antagonism therefore promotes RGC survival by regulating the BDNF and TrkB signaling pathway after ocular hypertension. © Federation of European Neuroscience Societies and Blackwell Publishing Ltd.
 
dc.description.naturelink_to_subscribed_fulltext
 
dc.identifier.citationEuropean Journal Of Neuroscience, 2010, v. 31 n. 6, p. 1091-1097 [How to Cite?]
DOI: http://dx.doi.org/10.1111/j.1460-9568.2010.07127.x
 
dc.identifier.citeulike6885051
 
dc.identifier.doihttp://dx.doi.org/10.1111/j.1460-9568.2010.07127.x
 
dc.identifier.epage1097
 
dc.identifier.isiWOS:000275674400011
Funding AgencyGrant Number
The University of Hong Kong Foundation for Educational Development and Research Limited
NSFC30801272
RFDP200805581160
Natural Science Foundation of Guangdong Province of China8451008901000852
Training Foundation for the Youth Scholars of Sun Yat-Sen University2009009
2009026
Science and Technology Foundation of Guangdong Province of China2006B36004010
2008B030301090
Chinese Academy of Sciences
Funding Information:

This study was supported by funding from the Jessie Ho Professorship in Neuroscience (The University of Hong Kong Foundation for Educational Development and Research Limited, and donation from Mr George Ho), and donations from Ms Tung Shai Yun and Ms Annie Tsao Wen Wei. This research is also supported by grants from the NSFC (30801272), RFDP (200805581160), Natural Science Foundation of Guangdong Province of China (8451008901000852), Training Foundation for the Youth Scholars of Sun Yat-Sen University (2009009, 2009026) and The Science and Technology Foundation of Guangdong Province of China (2006B36004010, 2008B030301090). Bai Ren Ji Hua provided a grant to B.H. (Chinese Academy of Sciences).

 
dc.identifier.issn0953-816X
2013 Impact Factor: 3.669
 
dc.identifier.issue6
 
dc.identifier.pmid20377621
 
dc.identifier.scopuseid_2-s2.0-77949543242
 
dc.identifier.spage1091
 
dc.identifier.urihttp://hdl.handle.net/10722/149736
 
dc.identifier.volume31
 
dc.languageeng
 
dc.publisherBlackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/EJN
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofEuropean Journal of Neuroscience
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAnimals
 
dc.subject.meshAntibodies - Pharmacology - Therapeutic Use
 
dc.subject.meshBrain-Derived Neurotrophic Factor - Immunology - Metabolism
 
dc.subject.meshCell Line, Transformed
 
dc.subject.meshDisease Models, Animal
 
dc.subject.meshFemale
 
dc.subject.meshGene Expression Regulation - Drug Effects - Physiology
 
dc.subject.meshImmunoprecipitation
 
dc.subject.meshIntraocular Pressure - Physiology
 
dc.subject.meshMembrane Proteins - Genetics - Immunology - Metabolism
 
dc.subject.meshNerve Tissue Proteins - Genetics - Immunology - Metabolism
 
dc.subject.meshOcular Hypertension - Drug Therapy - Metabolism - Pathology
 
dc.subject.meshPhosphorylation - Drug Effects - Physiology
 
dc.subject.meshRats
 
dc.subject.meshRats, Sprague-Dawley
 
dc.subject.meshReceptor, Trkb - Metabolism
 
dc.subject.meshRetina - Pathology
 
dc.subject.meshRetinal Ganglion Cells - Metabolism - Pathology
 
dc.subject.meshTime Factors
 
dc.titleLINGO-1 negatively regulates TrkB phosphorylation after ocular hypertension
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. Biogen IDEC
  3. University of Science and Technology of China
  4. Sun Yat-Sen University
  5. Jinan University