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Article: Visual response properties of Y cells in the detached feline retina

TitleVisual response properties of Y cells in the detached feline retina
Authors
Issue Date2010
PublisherAssociation for Research in Vision and Ophthalmology. The Journal's web site is located at http://www.iovs.org
Citation
Investigative Ophthalmology And Visual Science, 2010, v. 51 n. 2, p. 1208-1215 How to Cite?
Abstract
Purpose. To evaluate early changes in the visual response properties of Y cells in the detached feline retina. Methods. The retinas of young adult cats were detached by injection, with a glass micropipette, of a solution of 0.004% sodium hyaluronate in a balanced salt solution between the neural retina and the retinal pigment epithelium. At 1, 3, and 7 days after detachment, the eyes were removed. The eyecup was prepared as a flat mount in a recording chamber and superfused with medium. Extracellular single-unit responses from Y cells in the retinas were recorded. Results. One, 3, and 7 days after retinal detachment surgery, Y cells showed clear signs of functional deterioration. At each time point, more ON center cells than OFF cells were encountered. Y cells in the detached retinas showed a statistically significant elevation in the average threshold irradiance after 1-, 3-, and 7-day detachment, respectively. The average contrast threshold recorded from cells in the normal retina was 3.6%, but it increased to 14.5%, 21.8%, and 47.5% after 1-, 3-, and 7-day detachment, respectively. Furthermore, at each time point, the capability of Y cells to process contrast information decreased significantly more because of detachment than because of luminance task performance. Conclusions. Retinal detachment induced rapid functional remodeling that resulted in degenerated Y-cell function, including an elevated luminance threshold and a deteriorated contrast threshold. Detachment had a greater impact on the latter. These physiological changes after retinal detachment could be used as objective indicators of early deterioration of visual function in future studies of retinal remodeling. © Association for Research in Vision and Ophthalmology.
Persistent Identifierhttp://hdl.handle.net/10722/149734
ISSN
2013 Impact Factor: 3.661
2013 SCImago Journal Rankings: 2.185
ISI Accession Number ID
Funding AgencyGrant Number
National Science Foundation of China663031
Ministry of Science and Technology of China2007AA02Z146
2009CB320900
Funding Information:

Supported by National Science Foundation of China Grant 663031 and Ministry of Science and Technology of China Grants 2007AA02Z146 and 2009CB320900.

References

 

DC FieldValueLanguage
dc.contributor.authorNan, Yen_HK
dc.contributor.authorXiao, Cen_HK
dc.contributor.authorChen, Ben_HK
dc.contributor.authorEllisBehnke, RGen_HK
dc.contributor.authorSo, KFen_HK
dc.contributor.authorPu, Men_HK
dc.date.accessioned2012-06-26T05:57:47Z-
dc.date.available2012-06-26T05:57:47Z-
dc.date.issued2010en_HK
dc.identifier.citationInvestigative Ophthalmology And Visual Science, 2010, v. 51 n. 2, p. 1208-1215en_HK
dc.identifier.issn0146-0404en_HK
dc.identifier.urihttp://hdl.handle.net/10722/149734-
dc.description.abstractPurpose. To evaluate early changes in the visual response properties of Y cells in the detached feline retina. Methods. The retinas of young adult cats were detached by injection, with a glass micropipette, of a solution of 0.004% sodium hyaluronate in a balanced salt solution between the neural retina and the retinal pigment epithelium. At 1, 3, and 7 days after detachment, the eyes were removed. The eyecup was prepared as a flat mount in a recording chamber and superfused with medium. Extracellular single-unit responses from Y cells in the retinas were recorded. Results. One, 3, and 7 days after retinal detachment surgery, Y cells showed clear signs of functional deterioration. At each time point, more ON center cells than OFF cells were encountered. Y cells in the detached retinas showed a statistically significant elevation in the average threshold irradiance after 1-, 3-, and 7-day detachment, respectively. The average contrast threshold recorded from cells in the normal retina was 3.6%, but it increased to 14.5%, 21.8%, and 47.5% after 1-, 3-, and 7-day detachment, respectively. Furthermore, at each time point, the capability of Y cells to process contrast information decreased significantly more because of detachment than because of luminance task performance. Conclusions. Retinal detachment induced rapid functional remodeling that resulted in degenerated Y-cell function, including an elevated luminance threshold and a deteriorated contrast threshold. Detachment had a greater impact on the latter. These physiological changes after retinal detachment could be used as objective indicators of early deterioration of visual function in future studies of retinal remodeling. © Association for Research in Vision and Ophthalmology.en_HK
dc.languageengen_US
dc.publisherAssociation for Research in Vision and Ophthalmology. The Journal's web site is located at http://www.iovs.orgen_HK
dc.relation.ispartofInvestigative Ophthalmology and Visual Scienceen_HK
dc.titleVisual response properties of Y cells in the detached feline retinaen_HK
dc.typeArticleen_HK
dc.identifier.emailEllisBehnke, RG: rutledg@mit.eduen_HK
dc.identifier.emailSo, KF: hrmaskf@hku.hken_HK
dc.identifier.authorityEllisBehnke, RG=rp00252en_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1167/iovs.09-4179en_HK
dc.identifier.pmid19797207-
dc.identifier.scopuseid_2-s2.0-77449110750en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77449110750&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume51en_HK
dc.identifier.issue2en_HK
dc.identifier.spage1208en_HK
dc.identifier.epage1215en_HK
dc.identifier.isiWOS:000273704700079-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridNan, Y=35604117200en_HK
dc.identifier.scopusauthoridXiao, C=35604916100en_HK
dc.identifier.scopusauthoridChen, B=14051424300en_HK
dc.identifier.scopusauthoridEllisBehnke, RG=8548055200en_HK
dc.identifier.scopusauthoridSo, KF=34668391300en_HK
dc.identifier.scopusauthoridPu, M=16073321400en_HK

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