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Article: Visual response properties of Y cells in the detached feline retina
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TitleVisual response properties of Y cells in the detached feline retina
 
AuthorsNan, Y3
Xiao, C3
Chen, B3
EllisBehnke, RG2 1
So, KF2
Pu, M3
 
Issue Date2010
 
PublisherAssociation for Research in Vision and Ophthalmology. The Journal's web site is located at http://www.iovs.org
 
CitationInvestigative Ophthalmology And Visual Science, 2010, v. 51 n. 2, p. 1208-1215 [How to Cite?]
DOI: http://dx.doi.org/10.1167/iovs.09-4179
 
AbstractPurpose. To evaluate early changes in the visual response properties of Y cells in the detached feline retina. Methods. The retinas of young adult cats were detached by injection, with a glass micropipette, of a solution of 0.004% sodium hyaluronate in a balanced salt solution between the neural retina and the retinal pigment epithelium. At 1, 3, and 7 days after detachment, the eyes were removed. The eyecup was prepared as a flat mount in a recording chamber and superfused with medium. Extracellular single-unit responses from Y cells in the retinas were recorded. Results. One, 3, and 7 days after retinal detachment surgery, Y cells showed clear signs of functional deterioration. At each time point, more ON center cells than OFF cells were encountered. Y cells in the detached retinas showed a statistically significant elevation in the average threshold irradiance after 1-, 3-, and 7-day detachment, respectively. The average contrast threshold recorded from cells in the normal retina was 3.6%, but it increased to 14.5%, 21.8%, and 47.5% after 1-, 3-, and 7-day detachment, respectively. Furthermore, at each time point, the capability of Y cells to process contrast information decreased significantly more because of detachment than because of luminance task performance. Conclusions. Retinal detachment induced rapid functional remodeling that resulted in degenerated Y-cell function, including an elevated luminance threshold and a deteriorated contrast threshold. Detachment had a greater impact on the latter. These physiological changes after retinal detachment could be used as objective indicators of early deterioration of visual function in future studies of retinal remodeling. © Association for Research in Vision and Ophthalmology.
 
ISSN0146-0404
2012 Impact Factor: 3.441
2012 SCImago Journal Rankings: 1.828
 
DOIhttp://dx.doi.org/10.1167/iovs.09-4179
 
ISI Accession Number IDWOS:000273704700079
Funding AgencyGrant Number
National Science Foundation of China663031
Ministry of Science and Technology of China2007AA02Z146
2009CB320900
Funding Information:

Supported by National Science Foundation of China Grant 663031 and Ministry of Science and Technology of China Grants 2007AA02Z146 and 2009CB320900.

 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorNan, Y
 
dc.contributor.authorXiao, C
 
dc.contributor.authorChen, B
 
dc.contributor.authorEllisBehnke, RG
 
dc.contributor.authorSo, KF
 
dc.contributor.authorPu, M
 
dc.date.accessioned2012-06-26T05:57:47Z
 
dc.date.available2012-06-26T05:57:47Z
 
dc.date.issued2010
 
dc.description.abstractPurpose. To evaluate early changes in the visual response properties of Y cells in the detached feline retina. Methods. The retinas of young adult cats were detached by injection, with a glass micropipette, of a solution of 0.004% sodium hyaluronate in a balanced salt solution between the neural retina and the retinal pigment epithelium. At 1, 3, and 7 days after detachment, the eyes were removed. The eyecup was prepared as a flat mount in a recording chamber and superfused with medium. Extracellular single-unit responses from Y cells in the retinas were recorded. Results. One, 3, and 7 days after retinal detachment surgery, Y cells showed clear signs of functional deterioration. At each time point, more ON center cells than OFF cells were encountered. Y cells in the detached retinas showed a statistically significant elevation in the average threshold irradiance after 1-, 3-, and 7-day detachment, respectively. The average contrast threshold recorded from cells in the normal retina was 3.6%, but it increased to 14.5%, 21.8%, and 47.5% after 1-, 3-, and 7-day detachment, respectively. Furthermore, at each time point, the capability of Y cells to process contrast information decreased significantly more because of detachment than because of luminance task performance. Conclusions. Retinal detachment induced rapid functional remodeling that resulted in degenerated Y-cell function, including an elevated luminance threshold and a deteriorated contrast threshold. Detachment had a greater impact on the latter. These physiological changes after retinal detachment could be used as objective indicators of early deterioration of visual function in future studies of retinal remodeling. © Association for Research in Vision and Ophthalmology.
 
dc.description.naturelink_to_OA_fulltext
 
dc.identifier.citationInvestigative Ophthalmology And Visual Science, 2010, v. 51 n. 2, p. 1208-1215 [How to Cite?]
DOI: http://dx.doi.org/10.1167/iovs.09-4179
 
dc.identifier.doihttp://dx.doi.org/10.1167/iovs.09-4179
 
dc.identifier.epage1215
 
dc.identifier.isiWOS:000273704700079
Funding AgencyGrant Number
National Science Foundation of China663031
Ministry of Science and Technology of China2007AA02Z146
2009CB320900
Funding Information:

Supported by National Science Foundation of China Grant 663031 and Ministry of Science and Technology of China Grants 2007AA02Z146 and 2009CB320900.

 
dc.identifier.issn0146-0404
2012 Impact Factor: 3.441
2012 SCImago Journal Rankings: 1.828
 
dc.identifier.issue2
 
dc.identifier.pmid19797207
 
dc.identifier.scopuseid_2-s2.0-77449110750
 
dc.identifier.spage1208
 
dc.identifier.urihttp://hdl.handle.net/10722/149734
 
dc.identifier.volume51
 
dc.languageeng
 
dc.publisherAssociation for Research in Vision and Ophthalmology. The Journal's web site is located at http://www.iovs.org
 
dc.publisher.placeUnited States
 
dc.relation.ispartofInvestigative Ophthalmology and Visual Science
 
dc.relation.referencesReferences in Scopus
 
dc.titleVisual response properties of Y cells in the detached feline retina
 
dc.typeArticle
 
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<contributor.author>So, KF</contributor.author>
<contributor.author>Pu, M</contributor.author>
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<description.abstract>Purpose. To evaluate early changes in the visual response properties of Y cells in the detached feline retina. Methods. The retinas of young adult cats were detached by injection, with a glass micropipette, of a solution of 0.004% sodium hyaluronate in a balanced salt solution between the neural retina and the retinal pigment epithelium. At 1, 3, and 7 days after detachment, the eyes were removed. The eyecup was prepared as a flat mount in a recording chamber and superfused with medium. Extracellular single-unit responses from Y cells in the retinas were recorded. Results. One, 3, and 7 days after retinal detachment surgery, Y cells showed clear signs of functional deterioration. At each time point, more ON center cells than OFF cells were encountered. Y cells in the detached retinas showed a statistically significant elevation in the average threshold irradiance after 1-, 3-, and 7-day detachment, respectively. The average contrast threshold recorded from cells in the normal retina was 3.6%, but it increased to 14.5%, 21.8%, and 47.5% after 1-, 3-, and 7-day detachment, respectively. Furthermore, at each time point, the capability of Y cells to process contrast information decreased significantly more because of detachment than because of luminance task performance. Conclusions. Retinal detachment induced rapid functional remodeling that resulted in degenerated Y-cell function, including an elevated luminance threshold and a deteriorated contrast threshold. Detachment had a greater impact on the latter. These physiological changes after retinal detachment could be used as objective indicators of early deterioration of visual function in future studies of retinal remodeling. &#169; Association for Research in Vision and Ophthalmology.</description.abstract>
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Author Affiliations
  1. Massachusetts Institute of Technology
  2. The University of Hong Kong Li Ka Shing Faculty of Medicine
  3. Peking University