Article: Visual response properties of Y cells in the detached feline retina
| Title | Visual response properties of Y cells in the detached feline retina |
|---|---|
| Authors | Nan, Y3 Xiao, C3 Chen, B3 EllisBehnke, RG1 2 So, KF2 Pu, M3 |
| Issue Date | 2010 |
| Publisher | Association for Research in Vision and Ophthalmology. The Journal's web site is located at http://www.iovs.org |
| Citation | Investigative Ophthalmology And Visual Science, 2010, v. 51 n. 2, p. 1208-1215 [How to Cite?] DOI: http://dx.doi.org/10.1167/iovs.09-4179 |
| Abstract | Purpose. To evaluate early changes in the visual response properties of Y cells in the detached feline retina. Methods. The retinas of young adult cats were detached by injection, with a glass micropipette, of a solution of 0.004% sodium hyaluronate in a balanced salt solution between the neural retina and the retinal pigment epithelium. At 1, 3, and 7 days after detachment, the eyes were removed. The eyecup was prepared as a flat mount in a recording chamber and superfused with medium. Extracellular single-unit responses from Y cells in the retinas were recorded. Results. One, 3, and 7 days after retinal detachment surgery, Y cells showed clear signs of functional deterioration. At each time point, more ON center cells than OFF cells were encountered. Y cells in the detached retinas showed a statistically significant elevation in the average threshold irradiance after 1-, 3-, and 7-day detachment, respectively. The average contrast threshold recorded from cells in the normal retina was 3.6%, but it increased to 14.5%, 21.8%, and 47.5% after 1-, 3-, and 7-day detachment, respectively. Furthermore, at each time point, the capability of Y cells to process contrast information decreased significantly more because of detachment than because of luminance task performance. Conclusions. Retinal detachment induced rapid functional remodeling that resulted in degenerated Y-cell function, including an elevated luminance threshold and a deteriorated contrast threshold. Detachment had a greater impact on the latter. These physiological changes after retinal detachment could be used as objective indicators of early deterioration of visual function in future studies of retinal remodeling. © Association for Research in Vision and Ophthalmology. |
| ISSN | 0146-0404 2011 Impact Factor: 3.597 2011 SCImago Journal Rankings: 0.320 |
| DOI | http://dx.doi.org/10.1167/iovs.09-4179 |
| References | References in Scopus |
| dc.contributor.author | Nan, Y | ||||||
|---|---|---|---|---|---|---|---|
| dc.contributor.author | Xiao, C | ||||||
| dc.contributor.author | Chen, B | ||||||
| dc.contributor.author | EllisBehnke, RG | ||||||
| dc.contributor.author | So, KF | ||||||
| dc.contributor.author | Pu, M | ||||||
| dc.date.accessioned | 2012-06-26T05:57:47Z | ||||||
| dc.date.available | 2012-06-26T05:57:47Z | ||||||
| dc.date.issued | 2010 | ||||||
| dc.description.abstract | Purpose. To evaluate early changes in the visual response properties of Y cells in the detached feline retina. Methods. The retinas of young adult cats were detached by injection, with a glass micropipette, of a solution of 0.004% sodium hyaluronate in a balanced salt solution between the neural retina and the retinal pigment epithelium. At 1, 3, and 7 days after detachment, the eyes were removed. The eyecup was prepared as a flat mount in a recording chamber and superfused with medium. Extracellular single-unit responses from Y cells in the retinas were recorded. Results. One, 3, and 7 days after retinal detachment surgery, Y cells showed clear signs of functional deterioration. At each time point, more ON center cells than OFF cells were encountered. Y cells in the detached retinas showed a statistically significant elevation in the average threshold irradiance after 1-, 3-, and 7-day detachment, respectively. The average contrast threshold recorded from cells in the normal retina was 3.6%, but it increased to 14.5%, 21.8%, and 47.5% after 1-, 3-, and 7-day detachment, respectively. Furthermore, at each time point, the capability of Y cells to process contrast information decreased significantly more because of detachment than because of luminance task performance. Conclusions. Retinal detachment induced rapid functional remodeling that resulted in degenerated Y-cell function, including an elevated luminance threshold and a deteriorated contrast threshold. Detachment had a greater impact on the latter. These physiological changes after retinal detachment could be used as objective indicators of early deterioration of visual function in future studies of retinal remodeling. © Association for Research in Vision and Ophthalmology. | ||||||
| dc.description.nature | link_to_OA_fulltext | ||||||
| dc.identifier.citation | Investigative Ophthalmology And Visual Science, 2010, v. 51 n. 2, p. 1208-1215 [How to Cite?] DOI: http://dx.doi.org/10.1167/iovs.09-4179 | ||||||
| dc.identifier.doi | http://dx.doi.org/10.1167/iovs.09-4179 | ||||||
| dc.identifier.epage | 1215 | ||||||
| dc.identifier.isi | WOS:000273704700079
Funding Information: Supported by National Science Foundation of China Grant 663031 and Ministry of Science and Technology of China Grants 2007AA02Z146 and 2009CB320900. | ||||||
| dc.identifier.issn | 0146-0404 2011 Impact Factor: 3.597 2011 SCImago Journal Rankings: 0.320 | ||||||
| dc.identifier.issue | 2 | ||||||
| dc.identifier.pmid | 19797207 | ||||||
| dc.identifier.scopus | eid_2-s2.0-77449110750 | ||||||
| dc.identifier.spage | 1208 | ||||||
| dc.identifier.uri | http://hdl.handle.net/10722/149734 | ||||||
| dc.identifier.volume | 51 | ||||||
| dc.language | eng | ||||||
| dc.publisher | Association for Research in Vision and Ophthalmology. The Journal's web site is located at http://www.iovs.org | ||||||
| dc.publisher.place | United States | ||||||
| dc.relation.ispartof | Investigative Ophthalmology and Visual Science | ||||||
| dc.relation.references | References in Scopus | ||||||
| dc.title | Visual response properties of Y cells in the detached feline retina | ||||||
| dc.type | Article |
Author Affiliations
- Massachusetts Institute of Technology
- The University of Hong Kong Li Ka Shing Faculty of Medicine
- Peking University