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Article: Visual response properties of Y cells in the detached feline retina

TitleVisual response properties of Y cells in the detached feline retina
Authors
Issue Date2010
PublisherAssociation for Research in Vision and Ophthalmology. The Journal's web site is located at http://www.iovs.org
Citation
Investigative Ophthalmology And Visual Science, 2010, v. 51 n. 2, p. 1208-1215 How to Cite?
Abstract
Purpose. To evaluate early changes in the visual response properties of Y cells in the detached feline retina. Methods. The retinas of young adult cats were detached by injection, with a glass micropipette, of a solution of 0.004% sodium hyaluronate in a balanced salt solution between the neural retina and the retinal pigment epithelium. At 1, 3, and 7 days after detachment, the eyes were removed. The eyecup was prepared as a flat mount in a recording chamber and superfused with medium. Extracellular single-unit responses from Y cells in the retinas were recorded. Results. One, 3, and 7 days after retinal detachment surgery, Y cells showed clear signs of functional deterioration. At each time point, more ON center cells than OFF cells were encountered. Y cells in the detached retinas showed a statistically significant elevation in the average threshold irradiance after 1-, 3-, and 7-day detachment, respectively. The average contrast threshold recorded from cells in the normal retina was 3.6%, but it increased to 14.5%, 21.8%, and 47.5% after 1-, 3-, and 7-day detachment, respectively. Furthermore, at each time point, the capability of Y cells to process contrast information decreased significantly more because of detachment than because of luminance task performance. Conclusions. Retinal detachment induced rapid functional remodeling that resulted in degenerated Y-cell function, including an elevated luminance threshold and a deteriorated contrast threshold. Detachment had a greater impact on the latter. These physiological changes after retinal detachment could be used as objective indicators of early deterioration of visual function in future studies of retinal remodeling. © Association for Research in Vision and Ophthalmology.
Persistent Identifierhttp://hdl.handle.net/10722/149734
ISSN
2013 Impact Factor: 3.661
2013 SCImago Journal Rankings: 2.185
ISI Accession Number ID
Funding AgencyGrant Number
National Science Foundation of China663031
Ministry of Science and Technology of China2007AA02Z146
2009CB320900
Funding Information:

Supported by National Science Foundation of China Grant 663031 and Ministry of Science and Technology of China Grants 2007AA02Z146 and 2009CB320900.

References

 

Author Affiliations
  1. Massachusetts Institute of Technology
  2. The University of Hong Kong Li Ka Shing Faculty of Medicine
  3. Peking University
DC FieldValueLanguage
dc.contributor.authorNan, Yen_HK
dc.contributor.authorXiao, Cen_HK
dc.contributor.authorChen, Ben_HK
dc.contributor.authorEllisBehnke, RGen_HK
dc.contributor.authorSo, KFen_HK
dc.contributor.authorPu, Men_HK
dc.date.accessioned2012-06-26T05:57:47Z-
dc.date.available2012-06-26T05:57:47Z-
dc.date.issued2010en_HK
dc.identifier.citationInvestigative Ophthalmology And Visual Science, 2010, v. 51 n. 2, p. 1208-1215en_HK
dc.identifier.issn0146-0404en_HK
dc.identifier.urihttp://hdl.handle.net/10722/149734-
dc.description.abstractPurpose. To evaluate early changes in the visual response properties of Y cells in the detached feline retina. Methods. The retinas of young adult cats were detached by injection, with a glass micropipette, of a solution of 0.004% sodium hyaluronate in a balanced salt solution between the neural retina and the retinal pigment epithelium. At 1, 3, and 7 days after detachment, the eyes were removed. The eyecup was prepared as a flat mount in a recording chamber and superfused with medium. Extracellular single-unit responses from Y cells in the retinas were recorded. Results. One, 3, and 7 days after retinal detachment surgery, Y cells showed clear signs of functional deterioration. At each time point, more ON center cells than OFF cells were encountered. Y cells in the detached retinas showed a statistically significant elevation in the average threshold irradiance after 1-, 3-, and 7-day detachment, respectively. The average contrast threshold recorded from cells in the normal retina was 3.6%, but it increased to 14.5%, 21.8%, and 47.5% after 1-, 3-, and 7-day detachment, respectively. Furthermore, at each time point, the capability of Y cells to process contrast information decreased significantly more because of detachment than because of luminance task performance. Conclusions. Retinal detachment induced rapid functional remodeling that resulted in degenerated Y-cell function, including an elevated luminance threshold and a deteriorated contrast threshold. Detachment had a greater impact on the latter. These physiological changes after retinal detachment could be used as objective indicators of early deterioration of visual function in future studies of retinal remodeling. © Association for Research in Vision and Ophthalmology.en_HK
dc.languageengen_US
dc.publisherAssociation for Research in Vision and Ophthalmology. The Journal's web site is located at http://www.iovs.orgen_HK
dc.relation.ispartofInvestigative Ophthalmology and Visual Scienceen_HK
dc.titleVisual response properties of Y cells in the detached feline retinaen_HK
dc.typeArticleen_HK
dc.identifier.emailEllisBehnke, RG: rutledg@mit.eduen_HK
dc.identifier.emailSo, KF: hrmaskf@hku.hken_HK
dc.identifier.authorityEllisBehnke, RG=rp00252en_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1167/iovs.09-4179en_HK
dc.identifier.pmid19797207-
dc.identifier.scopuseid_2-s2.0-77449110750en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-77449110750&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume51en_HK
dc.identifier.issue2en_HK
dc.identifier.spage1208en_HK
dc.identifier.epage1215en_HK
dc.identifier.isiWOS:000273704700079-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridNan, Y=35604117200en_HK
dc.identifier.scopusauthoridXiao, C=35604916100en_HK
dc.identifier.scopusauthoridChen, B=14051424300en_HK
dc.identifier.scopusauthoridEllisBehnke, RG=8548055200en_HK
dc.identifier.scopusauthoridSo, KF=34668391300en_HK
dc.identifier.scopusauthoridPu, M=16073321400en_HK

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