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Article: The diversity of nNOS gene expression in avulsion-injured spinal motoneurons among laboratory rodents

TitleThe diversity of nNOS gene expression in avulsion-injured spinal motoneurons among laboratory rodents
Authors
Issue Date2010
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yniox
Citation
Nitric Oxide - Biology And Chemistry, 2010, v. 22 n. 1, p. 37-42 How to Cite?
AbstractRats, mice, and hamsters are commonly used laboratory rodents in the experimental modeling strategies of avulsion-induced motoneuron degenerations. It is necessary to study the species-specific gene expression in spinal cord in response to avulsion. We carried out the brachial roots avulsion in all animals and compared the survival and nNOS gene expression in injured motoneurons and spinal segments among the three species. The results showed that avulsion-induced loss of motoneurons was greatest in mice than that in hamsters or rats. Avulsion induced decrease of nNOS mRNA level in injured spinal segments in all three species, but greater in amplitude in rats and mice than that in hamsters. However, the de novo nNOS protein expression in injured motoneurons was higher in rats than in hamsters, none in mice. This study strongly suggests that the species diversity of nNOS gene must be considered when estimating the role of nNOS in motoneuron degenerations. © 2009 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/149725
ISSN
2015 Impact Factor: 3.76
2015 SCImago Journal Rankings: 1.292
ISI Accession Number ID
Funding AgencyGrant Number
National Science Foundation Council of China30672119
Research Grants Council of Guangdong2008B050100011
Funding Information:

This work was supported by grants from the National Science Foundation Council of China (30672119) and grants from the Research Grants Council of Guangdong (2008B050100011).

References

 

DC FieldValueLanguage
dc.contributor.authorWang, Jen_US
dc.contributor.authorYan, Len_US
dc.contributor.authorZhao, Xen_US
dc.contributor.authorWu, Wen_US
dc.contributor.authorZhou, LHen_US
dc.date.accessioned2012-06-26T05:57:40Z-
dc.date.available2012-06-26T05:57:40Z-
dc.date.issued2010en_US
dc.identifier.citationNitric Oxide - Biology And Chemistry, 2010, v. 22 n. 1, p. 37-42en_US
dc.identifier.issn1089-8603en_US
dc.identifier.urihttp://hdl.handle.net/10722/149725-
dc.description.abstractRats, mice, and hamsters are commonly used laboratory rodents in the experimental modeling strategies of avulsion-induced motoneuron degenerations. It is necessary to study the species-specific gene expression in spinal cord in response to avulsion. We carried out the brachial roots avulsion in all animals and compared the survival and nNOS gene expression in injured motoneurons and spinal segments among the three species. The results showed that avulsion-induced loss of motoneurons was greatest in mice than that in hamsters or rats. Avulsion induced decrease of nNOS mRNA level in injured spinal segments in all three species, but greater in amplitude in rats and mice than that in hamsters. However, the de novo nNOS protein expression in injured motoneurons was higher in rats than in hamsters, none in mice. This study strongly suggests that the species diversity of nNOS gene must be considered when estimating the role of nNOS in motoneuron degenerations. © 2009 Elsevier Inc. All rights reserved.en_US
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynioxen_US
dc.relation.ispartofNitric Oxide - Biology and Chemistryen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCricetinaeen_US
dc.subject.meshGene Expression Regulation, Enzymologic - Geneticsen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshMaleen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Inbred Balb Cen_US
dc.subject.meshMotor Neurons - Enzymology - Pathologyen_US
dc.subject.meshNadph Dehydrogenase - Metabolismen_US
dc.subject.meshNitric Oxide Synthase Type I - Geneticsen_US
dc.subject.meshRna, Messenger - Geneticsen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshReverse Transcriptase Polymerase Chain Reactionen_US
dc.subject.meshSpecies Specificityen_US
dc.subject.meshSpinal Cord Injuries - Enzymology - Pathologyen_US
dc.titleThe diversity of nNOS gene expression in avulsion-injured spinal motoneurons among laboratory rodentsen_US
dc.typeArticleen_US
dc.identifier.emailWu, W:wtwu@hkucc.hku.hken_US
dc.identifier.authorityWu, W=rp00419en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.niox.2009.11.005en_US
dc.identifier.pmid19931630-
dc.identifier.scopuseid_2-s2.0-73349099337en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-73349099337&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume22en_US
dc.identifier.issue1en_US
dc.identifier.spage37en_US
dc.identifier.epage42en_US
dc.identifier.isiWOS:000273642200005-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridWang, J=36090272400en_US
dc.identifier.scopusauthoridYan, L=7402671199en_US
dc.identifier.scopusauthoridZhao, X=36665560200en_US
dc.identifier.scopusauthoridWu, W=7407081122en_US
dc.identifier.scopusauthoridZhou, LH=7404125592en_US
dc.identifier.citeulike6189110-

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