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Article: GAP-43 expression correlates with spinal motoneuron regeneration following root avulsion
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TitleGAP-43 expression correlates with spinal motoneuron regeneration following root avulsion
 
AuthorsYuan, Q1 3
Hu, B1
Su, H1
So, K1 2 2
Lin, Z3
Wu, W1 2 1 2
 
Issue Date2009
 
PublisherBioMed Central Ltd. The Journal's web site is located at http://www.jbppni.com/home/
 
CitationJournal Of Brachial Plexus And Peripheral Nerve Injury, 2009, v. 4 n. 1, p. 18 [How to Cite?]
DOI: http://dx.doi.org/10.1186/1749-7221-4-18
 
AbstractBackground: The growth-associated protein GAP-43 plays a crucial role in axonal regeneration in injured neurons. Methods: We have used immunohistochemistry to investigate the expression of GAP-43 in spinal motoneurons during nerve reconstruction following root avulsion in the neonatal and adult rats. Results: Following the injury, GAP-43-immunoreactivity (IR) could be found in adult avulsed motoneurons as early as 1 day, increased from 3 to 7 days and reached a maximal level at 2 weeks post-injury. The up-regulation of GAP-43 in adult avulsed motoneurons was accompanied with the axonal regeneration indicated by numerous regenerating motor axons entering the reimplanted ventral root and nerve. In contrast, GAP-43-IR could not be found in the neonatal avulsed motoneurons at any examined post-injury time points. This failure of up-regulation of GAP-43 was coincident with no axonal regeneration in the reimplanted nerve in the neonatal rats. Conclusion: Close association of GAP-43 expression and capacity of regeneration in reimplanted spinal nerve of avulsed motoneurons suggests that GAP-43 is a potential therapeutic target for treatment of root avulsion of brachial plexus. © 2009 Yuan et al; licensee BioMed Central Ltd.
 
ISSN1749-7221
2012 SCImago Journal Rankings: 0.410
 
DOIhttp://dx.doi.org/10.1186/1749-7221-4-18
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorYuan, Q
 
dc.contributor.authorHu, B
 
dc.contributor.authorSu, H
 
dc.contributor.authorSo, K
 
dc.contributor.authorLin, Z
 
dc.contributor.authorWu, W
 
dc.date.accessioned2012-06-26T05:57:39Z
 
dc.date.available2012-06-26T05:57:39Z
 
dc.date.issued2009
 
dc.description.abstractBackground: The growth-associated protein GAP-43 plays a crucial role in axonal regeneration in injured neurons. Methods: We have used immunohistochemistry to investigate the expression of GAP-43 in spinal motoneurons during nerve reconstruction following root avulsion in the neonatal and adult rats. Results: Following the injury, GAP-43-immunoreactivity (IR) could be found in adult avulsed motoneurons as early as 1 day, increased from 3 to 7 days and reached a maximal level at 2 weeks post-injury. The up-regulation of GAP-43 in adult avulsed motoneurons was accompanied with the axonal regeneration indicated by numerous regenerating motor axons entering the reimplanted ventral root and nerve. In contrast, GAP-43-IR could not be found in the neonatal avulsed motoneurons at any examined post-injury time points. This failure of up-regulation of GAP-43 was coincident with no axonal regeneration in the reimplanted nerve in the neonatal rats. Conclusion: Close association of GAP-43 expression and capacity of regeneration in reimplanted spinal nerve of avulsed motoneurons suggests that GAP-43 is a potential therapeutic target for treatment of root avulsion of brachial plexus. © 2009 Yuan et al; licensee BioMed Central Ltd.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationJournal Of Brachial Plexus And Peripheral Nerve Injury, 2009, v. 4 n. 1, p. 18 [How to Cite?]
DOI: http://dx.doi.org/10.1186/1749-7221-4-18
 
dc.identifier.citeulike6112055
 
dc.identifier.doihttp://dx.doi.org/10.1186/1749-7221-4-18
 
dc.identifier.issn1749-7221
2012 SCImago Journal Rankings: 0.410
 
dc.identifier.issue1
 
dc.identifier.scopuseid_2-s2.0-70450237103
 
dc.identifier.spage18
 
dc.identifier.urihttp://hdl.handle.net/10722/149724
 
dc.identifier.volume4
 
dc.languageeng
 
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://www.jbppni.com/home/
 
dc.publisher.placeUnited Kingdom
 
dc.relation.ispartofJournal of Brachial Plexus and Peripheral Nerve Injury
 
dc.relation.referencesReferences in Scopus
 
dc.titleGAP-43 expression correlates with spinal motoneuron regeneration following root avulsion
 
dc.typeArticle
 
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<contributor.author>Hu, B</contributor.author>
<contributor.author>Su, H</contributor.author>
<contributor.author>So, K</contributor.author>
<contributor.author>Lin, Z</contributor.author>
<contributor.author>Wu, W</contributor.author>
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Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. The University of Hong Kong
  3. Chinese University of Hong Kong