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Article: GAP-43 expression correlates with spinal motoneuron regeneration following root avulsion

TitleGAP-43 expression correlates with spinal motoneuron regeneration following root avulsion
Authors
Issue Date2009
PublisherBioMed Central Ltd. The Journal's web site is located at http://www.jbppni.com/home/
Citation
Journal Of Brachial Plexus And Peripheral Nerve Injury, 2009, v. 4 n. 1, p. 18 How to Cite?
AbstractBackground: The growth-associated protein GAP-43 plays a crucial role in axonal regeneration in injured neurons. Methods: We have used immunohistochemistry to investigate the expression of GAP-43 in spinal motoneurons during nerve reconstruction following root avulsion in the neonatal and adult rats. Results: Following the injury, GAP-43-immunoreactivity (IR) could be found in adult avulsed motoneurons as early as 1 day, increased from 3 to 7 days and reached a maximal level at 2 weeks post-injury. The up-regulation of GAP-43 in adult avulsed motoneurons was accompanied with the axonal regeneration indicated by numerous regenerating motor axons entering the reimplanted ventral root and nerve. In contrast, GAP-43-IR could not be found in the neonatal avulsed motoneurons at any examined post-injury time points. This failure of up-regulation of GAP-43 was coincident with no axonal regeneration in the reimplanted nerve in the neonatal rats. Conclusion: Close association of GAP-43 expression and capacity of regeneration in reimplanted spinal nerve of avulsed motoneurons suggests that GAP-43 is a potential therapeutic target for treatment of root avulsion of brachial plexus. © 2009 Yuan et al; licensee BioMed Central Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/149724
ISSN
2014 SCImago Journal Rankings: 0.175
PubMed Central ID
References

 

DC FieldValueLanguage
dc.contributor.authorYuan, Qen_US
dc.contributor.authorHu, Ben_US
dc.contributor.authorSu, Hen_US
dc.contributor.authorSo, Ken_US
dc.contributor.authorLin, Zen_US
dc.contributor.authorWu, Wen_US
dc.date.accessioned2012-06-26T05:57:39Z-
dc.date.available2012-06-26T05:57:39Z-
dc.date.issued2009en_US
dc.identifier.citationJournal Of Brachial Plexus And Peripheral Nerve Injury, 2009, v. 4 n. 1, p. 18en_US
dc.identifier.issn1749-7221en_US
dc.identifier.urihttp://hdl.handle.net/10722/149724-
dc.description.abstractBackground: The growth-associated protein GAP-43 plays a crucial role in axonal regeneration in injured neurons. Methods: We have used immunohistochemistry to investigate the expression of GAP-43 in spinal motoneurons during nerve reconstruction following root avulsion in the neonatal and adult rats. Results: Following the injury, GAP-43-immunoreactivity (IR) could be found in adult avulsed motoneurons as early as 1 day, increased from 3 to 7 days and reached a maximal level at 2 weeks post-injury. The up-regulation of GAP-43 in adult avulsed motoneurons was accompanied with the axonal regeneration indicated by numerous regenerating motor axons entering the reimplanted ventral root and nerve. In contrast, GAP-43-IR could not be found in the neonatal avulsed motoneurons at any examined post-injury time points. This failure of up-regulation of GAP-43 was coincident with no axonal regeneration in the reimplanted nerve in the neonatal rats. Conclusion: Close association of GAP-43 expression and capacity of regeneration in reimplanted spinal nerve of avulsed motoneurons suggests that GAP-43 is a potential therapeutic target for treatment of root avulsion of brachial plexus. © 2009 Yuan et al; licensee BioMed Central Ltd.en_US
dc.languageengen_US
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://www.jbppni.com/home/en_US
dc.relation.ispartofJournal of Brachial Plexus and Peripheral Nerve Injuryen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.titleGAP-43 expression correlates with spinal motoneuron regeneration following root avulsionen_US
dc.typeArticleen_US
dc.identifier.emailSo, K:hrmaskf@hkucc.hku.hken_US
dc.identifier.emailWu, W:wtwu@hkucc.hku.hken_US
dc.identifier.authoritySo, K=rp00329en_US
dc.identifier.authorityWu, W=rp00419en_US
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.1186/1749-7221-4-18en_US
dc.identifier.pmid19852861-
dc.identifier.pmcidPMC2771005-
dc.identifier.scopuseid_2-s2.0-70450237103en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-70450237103&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume4en_US
dc.identifier.issue1en_US
dc.identifier.spage18en_US
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridYuan, Q=7202814773en_US
dc.identifier.scopusauthoridHu, B=35733928400en_US
dc.identifier.scopusauthoridSu, H=16317750200en_US
dc.identifier.scopusauthoridSo, K=34668391300en_US
dc.identifier.scopusauthoridLin, Z=26433004200en_US
dc.identifier.scopusauthoridWu, W=7407081122en_US
dc.identifier.citeulike6112055-

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