Article: GAP-43 expression correlates with spinal motoneuron regeneration following root avulsion

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TitleGAP-43 expression correlates with spinal motoneuron regeneration following root avulsion
AuthorsYuan, Q1 3
Hu, B1
Su, H1
So, K1 2
Lin, Z3
Wu, W1 2
Issue Date2009
PublisherBioMed Central Ltd. The Journal's web site is located at http://www.jbppni.com/home/
CitationJournal Of Brachial Plexus And Peripheral Nerve Injury, 2009, v. 4 n. 1, p. 18 [How to Cite?]
DOI: http://dx.doi.org/10.1186/1749-7221-4-18
AbstractBackground: The growth-associated protein GAP-43 plays a crucial role in axonal regeneration in injured neurons. Methods: We have used immunohistochemistry to investigate the expression of GAP-43 in spinal motoneurons during nerve reconstruction following root avulsion in the neonatal and adult rats. Results: Following the injury, GAP-43-immunoreactivity (IR) could be found in adult avulsed motoneurons as early as 1 day, increased from 3 to 7 days and reached a maximal level at 2 weeks post-injury. The up-regulation of GAP-43 in adult avulsed motoneurons was accompanied with the axonal regeneration indicated by numerous regenerating motor axons entering the reimplanted ventral root and nerve. In contrast, GAP-43-IR could not be found in the neonatal avulsed motoneurons at any examined post-injury time points. This failure of up-regulation of GAP-43 was coincident with no axonal regeneration in the reimplanted nerve in the neonatal rats. Conclusion: Close association of GAP-43 expression and capacity of regeneration in reimplanted spinal nerve of avulsed motoneurons suggests that GAP-43 is a potential therapeutic target for treatment of root avulsion of brachial plexus. © 2009 Yuan et al; licensee BioMed Central Ltd.
ISSN1749-7221
2011 SCImago Journal Rankings: 0.084
DOIhttp://dx.doi.org/10.1186/1749-7221-4-18
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorYuan, Q
dc.contributor.authorHu, B
dc.contributor.authorSu, H
dc.contributor.authorSo, K
dc.contributor.authorLin, Z
dc.contributor.authorWu, W
dc.date.accessioned2012-06-26T05:57:39Z
dc.date.available2012-06-26T05:57:39Z
dc.date.issued2009
dc.description.abstractBackground: The growth-associated protein GAP-43 plays a crucial role in axonal regeneration in injured neurons. Methods: We have used immunohistochemistry to investigate the expression of GAP-43 in spinal motoneurons during nerve reconstruction following root avulsion in the neonatal and adult rats. Results: Following the injury, GAP-43-immunoreactivity (IR) could be found in adult avulsed motoneurons as early as 1 day, increased from 3 to 7 days and reached a maximal level at 2 weeks post-injury. The up-regulation of GAP-43 in adult avulsed motoneurons was accompanied with the axonal regeneration indicated by numerous regenerating motor axons entering the reimplanted ventral root and nerve. In contrast, GAP-43-IR could not be found in the neonatal avulsed motoneurons at any examined post-injury time points. This failure of up-regulation of GAP-43 was coincident with no axonal regeneration in the reimplanted nerve in the neonatal rats. Conclusion: Close association of GAP-43 expression and capacity of regeneration in reimplanted spinal nerve of avulsed motoneurons suggests that GAP-43 is a potential therapeutic target for treatment of root avulsion of brachial plexus. © 2009 Yuan et al; licensee BioMed Central Ltd.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationJournal Of Brachial Plexus And Peripheral Nerve Injury, 2009, v. 4 n. 1, p. 18 [How to Cite?]
DOI: http://dx.doi.org/10.1186/1749-7221-4-18
dc.identifier.citeulike6112055
dc.identifier.doihttp://dx.doi.org/10.1186/1749-7221-4-18
dc.identifier.issn1749-7221
2011 SCImago Journal Rankings: 0.084
dc.identifier.issue1
dc.identifier.scopuseid_2-s2.0-70450237103
dc.identifier.spage18
dc.identifier.urihttp://hdl.handle.net/10722/149724
dc.identifier.volume4
dc.languageeng
dc.publisherBioMed Central Ltd. The Journal's web site is located at http://www.jbppni.com/home/
dc.publisher.placeUnited Kingdom
dc.relation.ispartofJournal of Brachial Plexus and Peripheral Nerve Injury
dc.relation.referencesReferences in Scopus
dc.titleGAP-43 expression correlates with spinal motoneuron regeneration following root avulsion
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong Li Ka Shing Faculty of Medicine
  2. The University of Hong Kong
  3. Chinese University of Hong Kong