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Article: Post pressure response of skin blood flowmotions in anesthetized rats with spinal cord injury

TitlePost pressure response of skin blood flowmotions in anesthetized rats with spinal cord injury
Authors
Issue Date2009
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ymvre
Citation
Microvascular Research, 2009, v. 78 n. 1, p. 20-24 How to Cite?
AbstractPressure ulcer is a common complication developed in persons with spinal cord injury (SCI) when prolonged unrelieved pressure was applied to the body/skin and underlying tissues. The objective of this study is to assess the hyperemic response of the skin blood flowmotions in anesthetized rats with spinal cord injury subjected to prolonged pressure using spectral analysis based on wavelets transform of the periodic oscillations of the cutaneous laser Doppler flowmetry (LDF) signal. A total of twenty-eight Sprague-Dawley rats were used in this study, of which 14 were normal rats and the other 14 were spinal cord injured rats with transection of the T1 spinal nerves. External pressure of 13.3 kPa (100 mmHg) was applied to the trochanter area of rats via a specifically designed indentors. The loading duration was 6 h. LDF measurement was monitored for 20 min prior to and after the prescribed compression period. Five frequency intervals were identified (0.01-0.05 Hz, 0.05-0.15 Hz, 0.15-0.4 Hz, 0.4-2 Hz and 2-5 Hz) corresponding to endothelial related metabolic, neurogenic, myogenic, respiratory and cardiac origins. The absolute amplitude of oscillations of each particular frequency interval and the normalized amplitude were calculated for quantitative assessments. Comparisons of hyperemic response were performed between SCI rats and normal ones. The results showed that the normalized amplitude in the frequency interval II (0.05-0.15 Hz) was significantly lower on SCI rats than that in normal ones (p < 0.01). Also, decreased reactive hyperemic response was observed in rats suffered from spinal cord injury. © 2009 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/149716
ISSN
2015 Impact Factor: 2.3
2015 SCImago Journal Rankings: 1.030
ISI Accession Number ID
Funding AgencyGrant Number
Central Research Grants of the Hong Kong Polytechnic UniversityG-YD72
G-YX35
Shandong Province Scientific Foundation for Young Talents2007BS03010
Funding Information:

This project has been supported by the Central Research Grants of the Hong Kong Polytechnic University (G-YD72 and G-YX35) and Shandong Province Scientific Foundation for Young Talents (2007BS03010).

References

 

DC FieldValueLanguage
dc.contributor.authorLi, Zen_US
dc.contributor.authorTam, EWCen_US
dc.contributor.authorLau, RYCen_US
dc.contributor.authorSo, KFen_US
dc.contributor.authorWu, Wen_US
dc.contributor.authorMak, AFTen_US
dc.date.accessioned2012-06-26T05:57:34Z-
dc.date.available2012-06-26T05:57:34Z-
dc.date.issued2009en_US
dc.identifier.citationMicrovascular Research, 2009, v. 78 n. 1, p. 20-24en_US
dc.identifier.issn0026-2862en_US
dc.identifier.urihttp://hdl.handle.net/10722/149716-
dc.description.abstractPressure ulcer is a common complication developed in persons with spinal cord injury (SCI) when prolonged unrelieved pressure was applied to the body/skin and underlying tissues. The objective of this study is to assess the hyperemic response of the skin blood flowmotions in anesthetized rats with spinal cord injury subjected to prolonged pressure using spectral analysis based on wavelets transform of the periodic oscillations of the cutaneous laser Doppler flowmetry (LDF) signal. A total of twenty-eight Sprague-Dawley rats were used in this study, of which 14 were normal rats and the other 14 were spinal cord injured rats with transection of the T1 spinal nerves. External pressure of 13.3 kPa (100 mmHg) was applied to the trochanter area of rats via a specifically designed indentors. The loading duration was 6 h. LDF measurement was monitored for 20 min prior to and after the prescribed compression period. Five frequency intervals were identified (0.01-0.05 Hz, 0.05-0.15 Hz, 0.15-0.4 Hz, 0.4-2 Hz and 2-5 Hz) corresponding to endothelial related metabolic, neurogenic, myogenic, respiratory and cardiac origins. The absolute amplitude of oscillations of each particular frequency interval and the normalized amplitude were calculated for quantitative assessments. Comparisons of hyperemic response were performed between SCI rats and normal ones. The results showed that the normalized amplitude in the frequency interval II (0.05-0.15 Hz) was significantly lower on SCI rats than that in normal ones (p < 0.01). Also, decreased reactive hyperemic response was observed in rats suffered from spinal cord injury. © 2009 Elsevier Inc. All rights reserved.en_US
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ymvreen_US
dc.relation.ispartofMicrovascular Researchen_US
dc.subject.meshAnesthesiaen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBlood Flow Velocity - Physiologyen_US
dc.subject.meshLaser-Doppler Flowmetry - Methodsen_US
dc.subject.meshPressureen_US
dc.subject.meshRandom Allocationen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshSkin - Blood Supply - Metabolismen_US
dc.subject.meshSkin Physiological Phenomenaen_US
dc.subject.meshSpinal Cord Injuries - Metabolismen_US
dc.titlePost pressure response of skin blood flowmotions in anesthetized rats with spinal cord injuryen_US
dc.typeArticleen_US
dc.identifier.emailSo, KF:hrmaskf@hkucc.hku.hken_US
dc.identifier.emailWu, W:wtwu@hkucc.hku.hken_US
dc.identifier.authoritySo, KF=rp00329en_US
dc.identifier.authorityWu, W=rp00419en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.mvr.2008.09.013en_US
dc.identifier.pmid19328816-
dc.identifier.scopuseid_2-s2.0-67349270624en_US
dc.identifier.hkuros172943-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-67349270624&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume78en_US
dc.identifier.issue1en_US
dc.identifier.spage20en_US
dc.identifier.epage24en_US
dc.identifier.isiWOS:000267308600004-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridLi, Z=13407279500en_US
dc.identifier.scopusauthoridTam, EWC=7005276007en_US
dc.identifier.scopusauthoridLau, RYC=15069277100en_US
dc.identifier.scopusauthoridSo, KF=34668391300en_US
dc.identifier.scopusauthoridWu, W=7407081122en_US
dc.identifier.scopusauthoridMak, AFT=35516744100en_US
dc.identifier.citeulike5310342-

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