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Article: Neurotrophin-3 improves retinoic acid-induced neural differentiation of skin-derived precursors through a p75NTR-dependent signaling pathway

TitleNeurotrophin-3 improves retinoic acid-induced neural differentiation of skin-derived precursors through a p75NTR-dependent signaling pathway
Authors
Issue Date2009
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neures
Citation
Neuroscience Research, 2009, v. 64 n. 2, p. 170-176 How to Cite?
AbstractSkin-derived precursors (SKPs) are derived from mesoblast and can differentiate into smooth muscle cells, adipocytes, and less neuronal phenotypes. This study demonstrates that retinoic acid (RA) improves SKPs exit from self-proliferation to neural differentiation through up-regulating of NeuroD and cell-cycle regulatory protein p21, meanwhile RA also induces p75 neurotrophin receptor (p75NTR) up-regulation and apoptosis of SKPs. When treated sequentially with neurotrophin-3 (NT-3) after RA induction, the survival and neural differentiation of SKPs were enhanced significantly, and cell apoptosis induced by RA was decreased. These effects could be reversed by p75NTR inhibitor Pep5 instead of Trk receptor inhibitor K252a. The results indicate that NT-3 improves the neural differentiation of SKPs induced by RA through a p75NTR-dependent signaling pathway. © 2009 Elsevier Ireland Ltd and the Japan Neuroscience Society.
Persistent Identifierhttp://hdl.handle.net/10722/149715
ISSN
2015 Impact Factor: 2.004
2015 SCImago Journal Rankings: 0.985
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhang, Wen_US
dc.contributor.authorZeng, Ysen_US
dc.contributor.authorWang, Jmen_US
dc.contributor.authorDing, Yen_US
dc.contributor.authorLi, Yen_US
dc.contributor.authorWu, Wen_US
dc.date.accessioned2012-06-26T05:57:33Z-
dc.date.available2012-06-26T05:57:33Z-
dc.date.issued2009en_US
dc.identifier.citationNeuroscience Research, 2009, v. 64 n. 2, p. 170-176en_US
dc.identifier.issn0168-0102en_US
dc.identifier.urihttp://hdl.handle.net/10722/149715-
dc.description.abstractSkin-derived precursors (SKPs) are derived from mesoblast and can differentiate into smooth muscle cells, adipocytes, and less neuronal phenotypes. This study demonstrates that retinoic acid (RA) improves SKPs exit from self-proliferation to neural differentiation through up-regulating of NeuroD and cell-cycle regulatory protein p21, meanwhile RA also induces p75 neurotrophin receptor (p75NTR) up-regulation and apoptosis of SKPs. When treated sequentially with neurotrophin-3 (NT-3) after RA induction, the survival and neural differentiation of SKPs were enhanced significantly, and cell apoptosis induced by RA was decreased. These effects could be reversed by p75NTR inhibitor Pep5 instead of Trk receptor inhibitor K252a. The results indicate that NT-3 improves the neural differentiation of SKPs induced by RA through a p75NTR-dependent signaling pathway. © 2009 Elsevier Ireland Ltd and the Japan Neuroscience Society.en_US
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/neuresen_US
dc.relation.ispartofNeuroscience Researchen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnimals, Newbornen_US
dc.subject.meshApoptosisen_US
dc.subject.meshCell Differentiationen_US
dc.subject.meshCell Proliferationen_US
dc.subject.meshCell Survivalen_US
dc.subject.meshCells, Cultureden_US
dc.subject.meshNeuroglia - Cytology - Drug Effectsen_US
dc.subject.meshNeurons - Cytology - Drug Effectsen_US
dc.subject.meshNeurotrophin 3 - Pharmacologyen_US
dc.subject.meshRatsen_US
dc.subject.meshReceptors, Nerve Growth Factor - Biosynthesis - Physiologyen_US
dc.subject.meshSignal Transductionen_US
dc.subject.meshSkin - Cytologyen_US
dc.subject.meshStem Cells - Cytology - Drug Effectsen_US
dc.subject.meshTretinoin - Pharmacologyen_US
dc.subject.meshUp-Regulationen_US
dc.titleNeurotrophin-3 improves retinoic acid-induced neural differentiation of skin-derived precursors through a p75NTR-dependent signaling pathwayen_US
dc.typeArticleen_US
dc.identifier.emailWu, W:wtwu@hkucc.hku.hken_US
dc.identifier.authorityWu, W=rp00419en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.neures.2009.02.010en_US
dc.identifier.pmid19428697-
dc.identifier.scopuseid_2-s2.0-67349193223en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-67349193223&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume64en_US
dc.identifier.issue2en_US
dc.identifier.spage170en_US
dc.identifier.epage176en_US
dc.identifier.isiWOS:000266431700006-
dc.publisher.placeIrelanden_US
dc.identifier.scopusauthoridZhang, W=36076785500en_US
dc.identifier.scopusauthoridZeng, Ys=8236229300en_US
dc.identifier.scopusauthoridWang, Jm=8320906700en_US
dc.identifier.scopusauthoridDing, Y=26535640000en_US
dc.identifier.scopusauthoridLi, Y=36012496400en_US
dc.identifier.scopusauthoridWu, W=7407081122en_US

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