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Article: Proteomic identification of malignant transformation-related proteins in esophageal squamous cell carcinoma

TitleProteomic identification of malignant transformation-related proteins in esophageal squamous cell carcinoma
Authors
Issue Date2008
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/35503
Citation
Journal Of Cellular Biochemistry, 2008, v. 104 n. 5, p. 1625-1635 How to Cite?
AbstractEsophageal cancer (EC) persists to be a leading cancer-related death in northern China. Clinical outcome of EC is the most dismal among many types of digestive tumors because EC at early stage is asymptomatic. The current study used 2-DE-based proteomics to identify differentially expressed proteins between esophageal cancer cell lines and immortal cell line. Fifteen proteins were identified with differences of more than five folds, comprising the down-regulation of annexin A2, histone deacetylase 10 isoform beta and protein disulfide-isomerase ER-60 precursor, and the up-regulation of heat shock 70 kDa protein 9B precursor, solute carrier family 44 Member 3, heterogeneous nuclear ribonucleoprotein L (hnRNP L), eukaryotic translation initiation factor 4A isoform 2, triosephosphate isomerasel (TPI), peroxiredoxinl (PRX1), forminotransferase cyclodeaminase form (FTCD), fibrinogen gamma-A chain precursor, kinesin-like DNA binding protein, lamin A/C, cyclophilin A (CypA), and transcription factor MTSG1. Expression pattern of annexin A2 was verified by Western blotting, immunocytochemistry and immunohistochemistry analysis. The implication of these protein alterations correlated to the esophageal malignant transformation is discussed. © 2008 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/149702
ISSN
2015 Impact Factor: 3.446
2015 SCImago Journal Rankings: 1.520
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorQi, YJen_US
dc.contributor.authorHe, QYen_US
dc.contributor.authorMa, YFen_US
dc.contributor.authorDu, YWen_US
dc.contributor.authorLiu, GCen_US
dc.contributor.authorLi, YJen_US
dc.contributor.authorTsao, GSWen_US
dc.contributor.authorNgai, SMen_US
dc.contributor.authorChiu, JFen_US
dc.date.accessioned2012-06-26T05:57:20Z-
dc.date.available2012-06-26T05:57:20Z-
dc.date.issued2008en_US
dc.identifier.citationJournal Of Cellular Biochemistry, 2008, v. 104 n. 5, p. 1625-1635en_US
dc.identifier.issn0730-2312en_US
dc.identifier.urihttp://hdl.handle.net/10722/149702-
dc.description.abstractEsophageal cancer (EC) persists to be a leading cancer-related death in northern China. Clinical outcome of EC is the most dismal among many types of digestive tumors because EC at early stage is asymptomatic. The current study used 2-DE-based proteomics to identify differentially expressed proteins between esophageal cancer cell lines and immortal cell line. Fifteen proteins were identified with differences of more than five folds, comprising the down-regulation of annexin A2, histone deacetylase 10 isoform beta and protein disulfide-isomerase ER-60 precursor, and the up-regulation of heat shock 70 kDa protein 9B precursor, solute carrier family 44 Member 3, heterogeneous nuclear ribonucleoprotein L (hnRNP L), eukaryotic translation initiation factor 4A isoform 2, triosephosphate isomerasel (TPI), peroxiredoxinl (PRX1), forminotransferase cyclodeaminase form (FTCD), fibrinogen gamma-A chain precursor, kinesin-like DNA binding protein, lamin A/C, cyclophilin A (CypA), and transcription factor MTSG1. Expression pattern of annexin A2 was verified by Western blotting, immunocytochemistry and immunohistochemistry analysis. The implication of these protein alterations correlated to the esophageal malignant transformation is discussed. © 2008 Wiley-Liss, Inc.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/35503en_US
dc.relation.ispartofJournal of Cellular Biochemistryen_US
dc.subject.meshAnnexins - Metabolismen_US
dc.subject.meshBlotting, Westernen_US
dc.subject.meshCarcinoma, Squamous Cell - Chemistry - Pathologyen_US
dc.subject.meshCell Adhesionen_US
dc.subject.meshCell Line, Tumoren_US
dc.subject.meshCell Transformation, Neoplastic - Chemistryen_US
dc.subject.meshElectrophoresis, Gel, Two-Dimensionalen_US
dc.subject.meshEsophageal Neoplasms - Chemistry - Pathologyen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshNeoplasm Proteins - Analysisen_US
dc.subject.meshProteomicsen_US
dc.titleProteomic identification of malignant transformation-related proteins in esophageal squamous cell carcinomaen_US
dc.typeArticleen_US
dc.identifier.emailTsao, GSW:gswtsao@hkucc.hku.hken_US
dc.identifier.authorityTsao, GSW=rp00399en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/jcb.21727en_US
dc.identifier.pmid18320592-
dc.identifier.scopuseid_2-s2.0-50249150192en_US
dc.identifier.hkuros151295-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-50249150192&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume104en_US
dc.identifier.issue5en_US
dc.identifier.spage1625en_US
dc.identifier.epage1635en_US
dc.identifier.isiWOS:000258240600011-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridQi, YJ=47461520800en_US
dc.identifier.scopusauthoridHe, QY=34770287900en_US
dc.identifier.scopusauthoridMa, YF=22951194700en_US
dc.identifier.scopusauthoridDu, YW=24068434500en_US
dc.identifier.scopusauthoridLiu, GC=27172050500en_US
dc.identifier.scopusauthoridLi, YJ=36154653600en_US
dc.identifier.scopusauthoridTsao, GSW=7102813116en_US
dc.identifier.scopusauthoridNgai, SM=7006074219en_US
dc.identifier.scopusauthoridChiu, JF=7201501692en_US

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