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Article: Use of anti-aging herbal medicine, Lycium barbarum, against aging-associated diseases. What do we know so far?

TitleUse of anti-aging herbal medicine, Lycium barbarum, against aging-associated diseases. What do we know so far?
Authors
Issue Date2008
PublisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0272-4340
Citation
Cellular And Molecular Neurobiology, 2008, v. 28 n. 5, p. 643-652 How to Cite?
AbstractLycium barbarum (Gouqizi, Fructus Lycii, Wolfberry) is well known for nourishing the liver, and in turn, improving the eyesight. However, many people have forgotten its anti-aging properties. Valuable components of L. barbarum are not limited to its colored components containing zeaxanthin and carotene, but include the polysaccharides and small molecules such as betaine, cerebroside, β-sitosterol, p-coumaric, and various vitamins. Despite the fact that L. barbarum has been used for centuries, its beneficial effects to our bodies have not been comprehensively studied with modern technology to unravel its therapeutic effects at the biochemical level. Recently, our laboratory has demonstrated its neuroprotective effects to counter neuronal loss in neurodegenerative diseases. Polysaccharides extracted from L. barbarum can protect neurons against β-amyloid peptide toxicity in neuronal cell cultures, and retinal ganglion cells in an experimental model of glaucoma. We have even isolated the active component of polysaccharide which can attenuate stress kinases and pro-apoptotic signaling pathways. We have accumulated scientific evidence for its anti-aging effects that should be highlighted for modern preventive medicine. This review is to provide background information and a new direction of study for the anti-aging properties of L. barbarum. We hope that new findings for L. barbarum will pave a new avenue for the use of Chinese medicine in modern evidence-based medicine. © 2007 Springer Science+Business Media, LLC.
Persistent Identifierhttp://hdl.handle.net/10722/149696
ISSN
2015 Impact Factor: 2.328
2015 SCImago Journal Rankings: 1.005
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChang, RCCen_US
dc.contributor.authorSo, KFen_US
dc.date.accessioned2012-06-26T05:57:12Z-
dc.date.available2012-06-26T05:57:12Z-
dc.date.issued2008en_US
dc.identifier.citationCellular And Molecular Neurobiology, 2008, v. 28 n. 5, p. 643-652en_US
dc.identifier.issn0272-4340en_US
dc.identifier.urihttp://hdl.handle.net/10722/149696-
dc.description.abstractLycium barbarum (Gouqizi, Fructus Lycii, Wolfberry) is well known for nourishing the liver, and in turn, improving the eyesight. However, many people have forgotten its anti-aging properties. Valuable components of L. barbarum are not limited to its colored components containing zeaxanthin and carotene, but include the polysaccharides and small molecules such as betaine, cerebroside, β-sitosterol, p-coumaric, and various vitamins. Despite the fact that L. barbarum has been used for centuries, its beneficial effects to our bodies have not been comprehensively studied with modern technology to unravel its therapeutic effects at the biochemical level. Recently, our laboratory has demonstrated its neuroprotective effects to counter neuronal loss in neurodegenerative diseases. Polysaccharides extracted from L. barbarum can protect neurons against β-amyloid peptide toxicity in neuronal cell cultures, and retinal ganglion cells in an experimental model of glaucoma. We have even isolated the active component of polysaccharide which can attenuate stress kinases and pro-apoptotic signaling pathways. We have accumulated scientific evidence for its anti-aging effects that should be highlighted for modern preventive medicine. This review is to provide background information and a new direction of study for the anti-aging properties of L. barbarum. We hope that new findings for L. barbarum will pave a new avenue for the use of Chinese medicine in modern evidence-based medicine. © 2007 Springer Science+Business Media, LLC.en_US
dc.languageengen_US
dc.publisherSpringer New York LLC. The Journal's web site is located at http://springerlink.metapress.com/openurl.asp?genre=journal&issn=0272-4340en_US
dc.relation.ispartofCellular and Molecular Neurobiologyen_US
dc.subject.meshAging - Drug Effects - Metabolismen_US
dc.subject.meshAmyloid Beta-Peptides - Antagonists & Inhibitors - Toxicityen_US
dc.subject.meshAnimalsen_US
dc.subject.meshApoptosis - Drug Effectsen_US
dc.subject.meshBrain - Drug Effects - Metabolism - Physiopathologyen_US
dc.subject.meshDrugs, Chinese Herbal - Pharmacology - Therapeutic Useen_US
dc.subject.meshHumansen_US
dc.subject.meshNeurodegenerative Diseases - Drug Therapy - Metabolism - Physiopathologyen_US
dc.subject.meshNeurons - Drug Effects - Metabolism - Pathologyen_US
dc.subject.meshNeuroprotective Agents - Pharmacology - Therapeutic Useen_US
dc.subject.meshOxidative Stress - Drug Effectsen_US
dc.titleUse of anti-aging herbal medicine, Lycium barbarum, against aging-associated diseases. What do we know so far?en_US
dc.typeArticleen_US
dc.identifier.emailChang, RCC:rccchang@hkucc.hku.hken_US
dc.identifier.emailSo, KF:hrmaskf@hkucc.hku.hken_US
dc.identifier.authorityChang, RCC=rp00470en_US
dc.identifier.authoritySo, KF=rp00329en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s10571-007-9181-xen_US
dc.identifier.pmid17710531-
dc.identifier.scopuseid_2-s2.0-46149090121en_US
dc.identifier.hkuros150973-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-46149090121&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume28en_US
dc.identifier.issue5en_US
dc.identifier.spage643en_US
dc.identifier.epage652en_US
dc.identifier.isiWOS:000257223300002-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridChang, RCC=7403713410en_US
dc.identifier.scopusauthoridSo, KF=34668391300en_US

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