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Article: Cytokeratin 8 silencing in human nasopharyngeal carcinoma cells leads to cisplatin sensitization

TitleCytokeratin 8 silencing in human nasopharyngeal carcinoma cells leads to cisplatin sensitization
Authors
Issue Date2008
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet
Citation
Cancer Letters, 2008, v. 265 n. 2, p. 188-196 How to Cite?
AbstractBy comparing protein profiles of nasopharyngeal carcinoma HONE1 cells to transformed nasopharyngeal epithelial NP 69 cells, several clusters of differentially expressed proteins were identified. The increased expression of cytokeratin 8 (CK8) and pyruvate kinase M2 was a common feature in four NPC cell lines compared to the two transformed epithelial cell lines. Suppression of CK8 was associated with the sensitivity to cisplatin in HONE1 cells; while overexpression of CK8 provided resistance to cisplatin-mediated apoptosis; and this protection occurred through an enhanced phosphorylation of c-Jun NH 2-terminal kinase (JNK). Our findings implicate an underlying molecular mechanism in which CK8 is required for cisplatin resistance. © 2008 Elsevier Ireland Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/149694
ISSN
2015 Impact Factor: 5.992
2015 SCImago Journal Rankings: 2.331
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWang, Yen_US
dc.contributor.authorHe, QYen_US
dc.contributor.authorTsao, SWen_US
dc.contributor.authorCheung, YHen_US
dc.contributor.authorWong, Aen_US
dc.contributor.authorChiu, JFen_US
dc.date.accessioned2012-06-26T05:57:11Z-
dc.date.available2012-06-26T05:57:11Z-
dc.date.issued2008en_US
dc.identifier.citationCancer Letters, 2008, v. 265 n. 2, p. 188-196en_US
dc.identifier.issn0304-3835en_US
dc.identifier.urihttp://hdl.handle.net/10722/149694-
dc.description.abstractBy comparing protein profiles of nasopharyngeal carcinoma HONE1 cells to transformed nasopharyngeal epithelial NP 69 cells, several clusters of differentially expressed proteins were identified. The increased expression of cytokeratin 8 (CK8) and pyruvate kinase M2 was a common feature in four NPC cell lines compared to the two transformed epithelial cell lines. Suppression of CK8 was associated with the sensitivity to cisplatin in HONE1 cells; while overexpression of CK8 provided resistance to cisplatin-mediated apoptosis; and this protection occurred through an enhanced phosphorylation of c-Jun NH 2-terminal kinase (JNK). Our findings implicate an underlying molecular mechanism in which CK8 is required for cisplatin resistance. © 2008 Elsevier Ireland Ltd. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canleten_US
dc.relation.ispartofCancer Lettersen_US
dc.subject.meshApoptosisen_US
dc.subject.meshCell Line, Transformeden_US
dc.subject.meshCell Line, Tumoren_US
dc.subject.meshCisplatin - Pharmacologyen_US
dc.subject.meshDrug Resistance, Neoplasm - Physiologyen_US
dc.subject.meshGene Silencingen_US
dc.subject.meshHumansen_US
dc.subject.meshJnk Mitogen-Activated Protein Kinases - Metabolismen_US
dc.subject.meshKeratin-8 - Physiologyen_US
dc.subject.meshNasopharyngeal Neoplasms - Metabolismen_US
dc.subject.meshPhosphorylationen_US
dc.subject.meshProtein Array Analysisen_US
dc.subject.meshTransfectionen_US
dc.titleCytokeratin 8 silencing in human nasopharyngeal carcinoma cells leads to cisplatin sensitizationen_US
dc.typeArticleen_US
dc.identifier.emailTsao, SW:gswtsao@hkucc.hku.hken_US
dc.identifier.authorityTsao, SW=rp00399en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.canlet.2008.02.015en_US
dc.identifier.pmid18353540-
dc.identifier.scopuseid_2-s2.0-43949102694en_US
dc.identifier.hkuros244340-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-43949102694&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume265en_US
dc.identifier.issue2en_US
dc.identifier.spage188en_US
dc.identifier.epage196en_US
dc.identifier.isiWOS:000256730500004-
dc.publisher.placeIrelanden_US
dc.identifier.scopusauthoridWang, Y=8222880500en_US
dc.identifier.scopusauthoridHe, QY=34770287900en_US
dc.identifier.scopusauthoridTsao, SW=7102813116en_US
dc.identifier.scopusauthoridCheung, YH=7202111455en_US
dc.identifier.scopusauthoridWong, A=35081505000en_US
dc.identifier.scopusauthoridChiu, JF=7201501692en_US

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