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Article: Adrenomedullin in the rat testis. II: Its production, actions on inhibin secretion, regulation by follicle-stimulating hormone, and its interaction with endothelin 1 in the Sertoli cell

TitleAdrenomedullin in the rat testis. II: Its production, actions on inhibin secretion, regulation by follicle-stimulating hormone, and its interaction with endothelin 1 in the Sertoli cell
Authors
KeywordsAdrenomedullin
Endothelin 1
Sertoli cells
Testis
Issue Date2008
PublisherSociety for the Study of Reproduction. The Journal's web site is located at http://www.biolreprod.org/
Citation
Biology Of Reproduction, 2008, v. 78 n. 4, p. 780-785 How to Cite?
AbstractThe present study demonstrates the expression of adrenomedullin (ADM) in the rat Sertoli cells and its effect on inhibin production. The regulation of ADM by FSH and its interaction with endothelin 1 (EDN1) in the rat Sertoli cells have also been established. Primary culture of Sertoli cells secreted 414 ± 27 pg immunoreactive ADM per 10 6 cells in 24 h and expressed Adm mRNA. In addition, the Sertoli cell was shown to co-express mRNAs encoding for the calcitonin receptor-like receptor (CALCRL) and receptor activity-modifying proteins (RAMPs) 1-3. These may account for the specific binding of ADM to the Sertoli cells. Administration of ADM to Sertoli cells resulted in an enhancement of basal and FSH-stimulated inhibin B production. On the other hand, the production of ADM and the mRNA levels of Calcrl and Ramp2 in the Sertoli cells were suppressed by FSH. The results suggest that ADM, via its control in the secretion of inhibin B, may play a role in regulating spermatogenesis as well as the hypothalamus-pituitary-gonad feedback system. In addition, like in the Leydig cell, ADM and EDN1 were found to regulate the production of each other in opposite directions in the Sertoli cells, suggesting the presence of yet another local regulatory mechanism in the rat testis that may be important in modulating testicular functions regulated by gonadotropins. © 2008 by the Society for the Study of Reproduction, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/149690
ISSN
2015 Impact Factor: 3.471
2015 SCImago Journal Rankings: 1.646
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, YFen_US
dc.contributor.authorTang, Fen_US
dc.contributor.authorO, WSen_US
dc.date.accessioned2012-06-26T05:57:09Z-
dc.date.available2012-06-26T05:57:09Z-
dc.date.issued2008en_US
dc.identifier.citationBiology Of Reproduction, 2008, v. 78 n. 4, p. 780-785en_US
dc.identifier.issn0006-3363en_US
dc.identifier.urihttp://hdl.handle.net/10722/149690-
dc.description.abstractThe present study demonstrates the expression of adrenomedullin (ADM) in the rat Sertoli cells and its effect on inhibin production. The regulation of ADM by FSH and its interaction with endothelin 1 (EDN1) in the rat Sertoli cells have also been established. Primary culture of Sertoli cells secreted 414 ± 27 pg immunoreactive ADM per 10 6 cells in 24 h and expressed Adm mRNA. In addition, the Sertoli cell was shown to co-express mRNAs encoding for the calcitonin receptor-like receptor (CALCRL) and receptor activity-modifying proteins (RAMPs) 1-3. These may account for the specific binding of ADM to the Sertoli cells. Administration of ADM to Sertoli cells resulted in an enhancement of basal and FSH-stimulated inhibin B production. On the other hand, the production of ADM and the mRNA levels of Calcrl and Ramp2 in the Sertoli cells were suppressed by FSH. The results suggest that ADM, via its control in the secretion of inhibin B, may play a role in regulating spermatogenesis as well as the hypothalamus-pituitary-gonad feedback system. In addition, like in the Leydig cell, ADM and EDN1 were found to regulate the production of each other in opposite directions in the Sertoli cells, suggesting the presence of yet another local regulatory mechanism in the rat testis that may be important in modulating testicular functions regulated by gonadotropins. © 2008 by the Society for the Study of Reproduction, Inc.en_US
dc.languageengen_US
dc.publisherSociety for the Study of Reproduction. The Journal's web site is located at http://www.biolreprod.org/en_US
dc.relation.ispartofBiology of Reproductionen_US
dc.subjectAdrenomedullin-
dc.subjectEndothelin 1-
dc.subjectSertoli cells-
dc.subjectTestis-
dc.subject.meshAdrenomedullin - Biosynthesis - Genetics - Pharmacology - Physiologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCalcitonin Receptor-Like Proteinen_US
dc.subject.meshCells, Cultureden_US
dc.subject.meshDrug Interactionsen_US
dc.subject.meshEndothelin-1 - Metabolism - Pharmacologyen_US
dc.subject.meshFeedback, Physiologicalen_US
dc.subject.meshFollicle Stimulating Hormone - Pharmacology - Physiologyen_US
dc.subject.meshGene Expression - Drug Effectsen_US
dc.subject.meshInhibins - Secretionen_US
dc.subject.meshIntracellular Signaling Peptides And Proteins - Geneticsen_US
dc.subject.meshMaleen_US
dc.subject.meshMembrane Proteins - Geneticsen_US
dc.subject.meshRna, Messenger - Analysisen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshReceptor Activity-Modifying Protein 2en_US
dc.subject.meshReceptor Activity-Modifying Proteinsen_US
dc.subject.meshReceptors, Calcitonin - Geneticsen_US
dc.subject.meshSertoli Cells - Drug Effects - Secretionen_US
dc.subject.meshSpermatogenesis - Physiologyen_US
dc.subject.meshTestis - Drug Effects - Metabolismen_US
dc.titleAdrenomedullin in the rat testis. II: Its production, actions on inhibin secretion, regulation by follicle-stimulating hormone, and its interaction with endothelin 1 in the Sertoli cellen_US
dc.typeArticleen_US
dc.identifier.emailTang, F:ftang@hkucc.hku.hken_US
dc.identifier.emailO, WS:owaisum@hkucc.hku.hken_US
dc.identifier.emailChan, YF: jenny.yf.chan@gmail.com-
dc.identifier.authorityTang, F=rp00327en_US
dc.identifier.authorityO, WS=rp00315en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.doi10.1095/biolreprod.107.060863en_US
dc.identifier.pmid18094364-
dc.identifier.scopuseid_2-s2.0-41549108442en_US
dc.identifier.hkuros141396-
dc.identifier.hkuros151734-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-41549108442&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume78en_US
dc.identifier.issue4en_US
dc.identifier.spage780en_US
dc.identifier.epage785en_US
dc.identifier.isiWOS:000254217500024-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridChan, YF=7403676061en_US
dc.identifier.scopusauthoridTang, F=7201979770en_US
dc.identifier.scopusauthoridO, WS=6701729369en_US

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