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Article: Evaluation of the retina and optic nerve in a rat model of chronic glaucoma using in vivo manganese-enhanced magnetic resonance imaging

TitleEvaluation of the retina and optic nerve in a rat model of chronic glaucoma using in vivo manganese-enhanced magnetic resonance imaging
Authors
KeywordsChronic glaucoma
Fast axonal transport
Intraocular pressure
Manganese-enhanced magnetic resonance imaging
Optic nerve
Rat
Issue Date2008
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynimg
Citation
Neuroimage, 2008, v. 40 n. 3, p. 1166-1174 How to Cite?
AbstractGlaucoma is a neurodegenerative disease of the visual system. While elevated intraocular pressure is considered to be a major risk factor, the primary cause and pathogenesis of the disease are still unclear. This study aims to employ in vivo manganese-enhanced magnetic resonance imaging (MEMRI) to evaluate dynamically the Mn2+ enhancements in the visual components following an induction of ocular hypertension in a rat model of chronic glaucoma. The episcleral and limbal veins were photocoagulated unilaterally in the right eye using an argon laser to maintain a consistent elevation of intraocular pressure by about 1.6 times above the normal level. Two and six weeks after glaucoma induction, MnCl2 solution (50 mM, 3 μL) was injected intravitreally into both eyes, and MEMRI was performed 2 to 5 h after injection. Results showed a delayed increase in T1-weighted signal intensity in the glaucomatous optic nerve at 6 weeks but not 2 weeks after glaucoma induction. In addition, there was an accumulation of Mn2+ ions in the vitreous humour of the glaucomatous eye, with a high concentration of Mn2+ ions at the optic nerve head and the retina. These MEMRI findings may help understand the disease mechanisms, monitor the effect of drug interventions in glaucoma models and complement the conventional techniques in examining the glaucomatous visual components. © 2008 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/149687
ISSN
2015 Impact Factor: 5.463
2015 SCImago Journal Rankings: 4.464
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, KCen_HK
dc.contributor.authorFu, Qlen_HK
dc.contributor.authorHui, ESen_HK
dc.contributor.authorSo, Kfen_HK
dc.contributor.authorWu, EXen_HK
dc.date.accessioned2012-06-26T05:57:06Z-
dc.date.available2012-06-26T05:57:06Z-
dc.date.issued2008en_HK
dc.identifier.citationNeuroimage, 2008, v. 40 n. 3, p. 1166-1174en_HK
dc.identifier.issn1053-8119en_HK
dc.identifier.urihttp://hdl.handle.net/10722/149687-
dc.description.abstractGlaucoma is a neurodegenerative disease of the visual system. While elevated intraocular pressure is considered to be a major risk factor, the primary cause and pathogenesis of the disease are still unclear. This study aims to employ in vivo manganese-enhanced magnetic resonance imaging (MEMRI) to evaluate dynamically the Mn2+ enhancements in the visual components following an induction of ocular hypertension in a rat model of chronic glaucoma. The episcleral and limbal veins were photocoagulated unilaterally in the right eye using an argon laser to maintain a consistent elevation of intraocular pressure by about 1.6 times above the normal level. Two and six weeks after glaucoma induction, MnCl2 solution (50 mM, 3 μL) was injected intravitreally into both eyes, and MEMRI was performed 2 to 5 h after injection. Results showed a delayed increase in T1-weighted signal intensity in the glaucomatous optic nerve at 6 weeks but not 2 weeks after glaucoma induction. In addition, there was an accumulation of Mn2+ ions in the vitreous humour of the glaucomatous eye, with a high concentration of Mn2+ ions at the optic nerve head and the retina. These MEMRI findings may help understand the disease mechanisms, monitor the effect of drug interventions in glaucoma models and complement the conventional techniques in examining the glaucomatous visual components. © 2008 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ynimgen_HK
dc.relation.ispartofNeuroImageen_HK
dc.subjectChronic glaucomaen_HK
dc.subjectFast axonal transporten_HK
dc.subjectIntraocular pressureen_HK
dc.subjectManganese-enhanced magnetic resonance imagingen_HK
dc.subjectOptic nerveen_HK
dc.subjectRaten_HK
dc.subject.meshAnimalsen_US
dc.subject.meshChronic Diseaseen_US
dc.subject.meshData Interpretation, Statisticalen_US
dc.subject.meshDisease Models, Animalen_US
dc.subject.meshFemaleen_US
dc.subject.meshFunctional Laterality - Physiologyen_US
dc.subject.meshGlaucoma - Metabolism - Pathologyen_US
dc.subject.meshMagnetic Resonance Imaging - Methodsen_US
dc.subject.meshManganese - Diagnostic Use - Metabolismen_US
dc.subject.meshOptic Nerve - Metabolism - Pathologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshRetina - Metabolism - Pathologyen_US
dc.subject.meshVitreous Body - Metabolismen_US
dc.titleEvaluation of the retina and optic nerve in a rat model of chronic glaucoma using in vivo manganese-enhanced magnetic resonance imagingen_HK
dc.typeArticleen_HK
dc.identifier.emailSo, Kf:hrmaskf@hkucc.hku.hken_HK
dc.identifier.emailWu, EX:ewu1@hkucc.hku.hken_HK
dc.identifier.authoritySo, Kf=rp00329en_HK
dc.identifier.authorityWu, EX=rp00193en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.neuroimage.2008.01.002en_HK
dc.identifier.pmid18272401-
dc.identifier.scopuseid_2-s2.0-40849095785en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-40849095785&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume40en_HK
dc.identifier.issue3en_HK
dc.identifier.spage1166en_HK
dc.identifier.epage1174en_HK
dc.identifier.isiWOS:000254728200015-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridChan, KC=34968940300en_HK
dc.identifier.scopusauthoridFu, Ql=23388762000en_HK
dc.identifier.scopusauthoridHui, ES=16175117100en_HK
dc.identifier.scopusauthoridSo, Kf=34668391300en_HK
dc.identifier.scopusauthoridWu, EX=7202128034en_HK

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