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Article: The activation of p53 mediated by Epstein-Barr virus latent membrane protein 1 in SV40 large T-antigen transformed cells
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TitleThe activation of p53 mediated by Epstein-Barr virus latent membrane protein 1 in SV40 large T-antigen transformed cells
 
AuthorsLi, L3
Zhou, S2
Chen, X3
Guo, L3
Li, Z3
Hu, D3
Luo, X3
Ma, X3
Tang, M3
Yi, W3
Tsao, SW1
Cao, Y3
 
Issue Date2008
 
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/febslet
 
CitationFEBS Letters, 2008, v. 582 n. 5, p. 755-762 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.febslet.2008.01.031
 
AbstractThe Epstein-Barr virus (EBV) encoded latent membrane protein 1 (LMP1) plays an important role in the carcinogenesis of nasopharyngeal carcinoma (NPC). The tumor suppressor p53 is an important transcription factor. The mutation of the p53 gene is the frequent alteration in most of tumors, but nearly 100% wild-type p53 gene is found in NPC biopsy. Here, our study testified that SV40 T-antigen transformed nasopharyngeal epithelial cells contained free, wild-type p53. Moreover, LMP1 regulated p53 both at transcriptional and translational level. Furthermore, the mechanism of p53 accumulation mediated by LMP1 from post-translational level-phosphorylation and ubiquitination were determined. Therefore, the effects of EBV LMP1 on p53 may potentially contribute to EBV-associated pathogenesis. © 2008.
 
ISSN0014-5793
2013 Impact Factor: 3.341
2013 SCImago Journal Rankings: 2.342
 
DOIhttp://dx.doi.org/10.1016/j.febslet.2008.01.031
 
ISI Accession Number IDWOS:000257670100036
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorLi, L
 
dc.contributor.authorZhou, S
 
dc.contributor.authorChen, X
 
dc.contributor.authorGuo, L
 
dc.contributor.authorLi, Z
 
dc.contributor.authorHu, D
 
dc.contributor.authorLuo, X
 
dc.contributor.authorMa, X
 
dc.contributor.authorTang, M
 
dc.contributor.authorYi, W
 
dc.contributor.authorTsao, SW
 
dc.contributor.authorCao, Y
 
dc.date.accessioned2012-06-26T05:57:06Z
 
dc.date.available2012-06-26T05:57:06Z
 
dc.date.issued2008
 
dc.description.abstractThe Epstein-Barr virus (EBV) encoded latent membrane protein 1 (LMP1) plays an important role in the carcinogenesis of nasopharyngeal carcinoma (NPC). The tumor suppressor p53 is an important transcription factor. The mutation of the p53 gene is the frequent alteration in most of tumors, but nearly 100% wild-type p53 gene is found in NPC biopsy. Here, our study testified that SV40 T-antigen transformed nasopharyngeal epithelial cells contained free, wild-type p53. Moreover, LMP1 regulated p53 both at transcriptional and translational level. Furthermore, the mechanism of p53 accumulation mediated by LMP1 from post-translational level-phosphorylation and ubiquitination were determined. Therefore, the effects of EBV LMP1 on p53 may potentially contribute to EBV-associated pathogenesis. © 2008.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationFEBS Letters, 2008, v. 582 n. 5, p. 755-762 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.febslet.2008.01.031
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.febslet.2008.01.031
 
dc.identifier.epage762
 
dc.identifier.hkuros151297
 
dc.identifier.isiWOS:000257670100036
 
dc.identifier.issn0014-5793
2013 Impact Factor: 3.341
2013 SCImago Journal Rankings: 2.342
 
dc.identifier.issue5
 
dc.identifier.pmid18242176
 
dc.identifier.scopuseid_2-s2.0-39649125193
 
dc.identifier.spage755
 
dc.identifier.urihttp://hdl.handle.net/10722/149686
 
dc.identifier.volume582
 
dc.languageeng
 
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/febslet
 
dc.publisher.placeNetherlands
 
dc.relation.ispartofFEBS Letters
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAntigens, Viral, Tumor - Genetics - Metabolism
 
dc.subject.meshCell Extracts
 
dc.subject.meshCell Line, Transformed
 
dc.subject.meshEpithelial Cells - Cytology - Metabolism - Radiation Effects
 
dc.subject.meshGene Expression Regulation - Radiation Effects
 
dc.subject.meshHumans
 
dc.subject.meshImmunoprecipitation
 
dc.subject.meshNasopharynx - Cytology - Metabolism - Radiation Effects
 
dc.subject.meshProtein Biosynthesis - Radiation Effects
 
dc.subject.meshProtein Transport - Radiation Effects
 
dc.subject.meshRna, Messenger - Genetics - Metabolism
 
dc.subject.meshRadiation, Ionizing
 
dc.subject.meshSimian Virus 40
 
dc.subject.meshTranscription, Genetic - Radiation Effects
 
dc.subject.meshTumor Suppressor Protein P53 - Genetics - Metabolism
 
dc.subject.meshUbiquitination - Radiation Effects
 
dc.subject.meshViral Matrix Proteins - Metabolism
 
dc.titleThe activation of p53 mediated by Epstein-Barr virus latent membrane protein 1 in SV40 large T-antigen transformed cells
 
dc.typeArticle
 
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<description.abstract>The Epstein-Barr virus (EBV) encoded latent membrane protein 1 (LMP1) plays an important role in the carcinogenesis of nasopharyngeal carcinoma (NPC). The tumor suppressor p53 is an important transcription factor. The mutation of the p53 gene is the frequent alteration in most of tumors, but nearly 100% wild-type p53 gene is found in NPC biopsy. Here, our study testified that SV40 T-antigen transformed nasopharyngeal epithelial cells contained free, wild-type p53. Moreover, LMP1 regulated p53 both at transcriptional and translational level. Furthermore, the mechanism of p53 accumulation mediated by LMP1 from post-translational level-phosphorylation and ubiquitination were determined. Therefore, the effects of EBV LMP1 on p53 may potentially contribute to EBV-associated pathogenesis. &#169; 2008.</description.abstract>
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Author Affiliations
  1. The University of Hong Kong
  2. Xiangya Hospital of Central-south University
  3. Central South University China