Article: The activation of p53 mediated by Epstein-Barr virus latent membrane protein 1 in SV40 large T-antigen transformed cells

File Download Links for fulltext
(May Require Subscription)
Supplementary
  • Basic View
  • Metadata View
  • XML View
TitleThe activation of p53 mediated by Epstein-Barr virus latent membrane protein 1 in SV40 large T-antigen transformed cells
AuthorsLi, L3
Zhou, S2
Chen, X3
Guo, L3
Li, Z3
Hu, D3
Luo, X3
Ma, X3
Tang, M3
Yi, W3
Tsao, SW1
Cao, Y3
Issue Date2008
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/febslet
CitationFEBS Letters, 2008, v. 582 n. 5, p. 755-762 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.febslet.2008.01.031
AbstractThe Epstein-Barr virus (EBV) encoded latent membrane protein 1 (LMP1) plays an important role in the carcinogenesis of nasopharyngeal carcinoma (NPC). The tumor suppressor p53 is an important transcription factor. The mutation of the p53 gene is the frequent alteration in most of tumors, but nearly 100% wild-type p53 gene is found in NPC biopsy. Here, our study testified that SV40 T-antigen transformed nasopharyngeal epithelial cells contained free, wild-type p53. Moreover, LMP1 regulated p53 both at transcriptional and translational level. Furthermore, the mechanism of p53 accumulation mediated by LMP1 from post-translational level-phosphorylation and ubiquitination were determined. Therefore, the effects of EBV LMP1 on p53 may potentially contribute to EBV-associated pathogenesis. © 2008.
ISSN0014-5793
2011 Impact Factor: 3.538
2011 SCImago Journal Rankings: 0.484
DOIhttp://dx.doi.org/10.1016/j.febslet.2008.01.031
ISI Accession Number IDWOS:000257670100036
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorLi, L
dc.contributor.authorZhou, S
dc.contributor.authorChen, X
dc.contributor.authorGuo, L
dc.contributor.authorLi, Z
dc.contributor.authorHu, D
dc.contributor.authorLuo, X
dc.contributor.authorMa, X
dc.contributor.authorTang, M
dc.contributor.authorYi, W
dc.contributor.authorTsao, SW
dc.contributor.authorCao, Y
dc.date.accessioned2012-06-26T05:57:06Z
dc.date.available2012-06-26T05:57:06Z
dc.date.issued2008
dc.description.abstractThe Epstein-Barr virus (EBV) encoded latent membrane protein 1 (LMP1) plays an important role in the carcinogenesis of nasopharyngeal carcinoma (NPC). The tumor suppressor p53 is an important transcription factor. The mutation of the p53 gene is the frequent alteration in most of tumors, but nearly 100% wild-type p53 gene is found in NPC biopsy. Here, our study testified that SV40 T-antigen transformed nasopharyngeal epithelial cells contained free, wild-type p53. Moreover, LMP1 regulated p53 both at transcriptional and translational level. Furthermore, the mechanism of p53 accumulation mediated by LMP1 from post-translational level-phosphorylation and ubiquitination were determined. Therefore, the effects of EBV LMP1 on p53 may potentially contribute to EBV-associated pathogenesis. © 2008.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationFEBS Letters, 2008, v. 582 n. 5, p. 755-762 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.febslet.2008.01.031
dc.identifier.doihttp://dx.doi.org/10.1016/j.febslet.2008.01.031
dc.identifier.epage762
dc.identifier.hkuros151297
dc.identifier.isiWOS:000257670100036
dc.identifier.issn0014-5793
2011 Impact Factor: 3.538
2011 SCImago Journal Rankings: 0.484
dc.identifier.issue5
dc.identifier.pmid18242176
dc.identifier.scopuseid_2-s2.0-39649125193
dc.identifier.spage755
dc.identifier.urihttp://hdl.handle.net/10722/149686
dc.identifier.volume582
dc.languageeng
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/febslet
dc.publisher.placeNetherlands
dc.relation.ispartofFEBS Letters
dc.relation.referencesReferences in Scopus
dc.subject.meshAntigens, Viral, Tumor - Genetics - Metabolism
dc.subject.meshCell Extracts
dc.subject.meshCell Line, Transformed
dc.subject.meshEpithelial Cells - Cytology - Metabolism - Radiation Effects
dc.subject.meshGene Expression Regulation - Radiation Effects
dc.subject.meshHumans
dc.subject.meshImmunoprecipitation
dc.subject.meshNasopharynx - Cytology - Metabolism - Radiation Effects
dc.subject.meshProtein Biosynthesis - Radiation Effects
dc.subject.meshProtein Transport - Radiation Effects
dc.subject.meshRna, Messenger - Genetics - Metabolism
dc.subject.meshRadiation, Ionizing
dc.subject.meshSimian Virus 40
dc.subject.meshTranscription, Genetic - Radiation Effects
dc.subject.meshTumor Suppressor Protein P53 - Genetics - Metabolism
dc.subject.meshUbiquitination - Radiation Effects
dc.subject.meshViral Matrix Proteins - Metabolism
dc.titleThe activation of p53 mediated by Epstein-Barr virus latent membrane protein 1 in SV40 large T-antigen transformed cells
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong
  2. Xiangya Hospital of Central-south University
  3. Central South University China