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Article: The activation of p53 mediated by Epstein-Barr virus latent membrane protein 1 in SV40 large T-antigen transformed cells

TitleThe activation of p53 mediated by Epstein-Barr virus latent membrane protein 1 in SV40 large T-antigen transformed cells
Authors
Issue Date2008
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/febslet
Citation
FEBS Letters, 2008, v. 582 n. 5, p. 755-762 How to Cite?
Abstract
The Epstein-Barr virus (EBV) encoded latent membrane protein 1 (LMP1) plays an important role in the carcinogenesis of nasopharyngeal carcinoma (NPC). The tumor suppressor p53 is an important transcription factor. The mutation of the p53 gene is the frequent alteration in most of tumors, but nearly 100% wild-type p53 gene is found in NPC biopsy. Here, our study testified that SV40 T-antigen transformed nasopharyngeal epithelial cells contained free, wild-type p53. Moreover, LMP1 regulated p53 both at transcriptional and translational level. Furthermore, the mechanism of p53 accumulation mediated by LMP1 from post-translational level-phosphorylation and ubiquitination were determined. Therefore, the effects of EBV LMP1 on p53 may potentially contribute to EBV-associated pathogenesis. © 2008.
Persistent Identifierhttp://hdl.handle.net/10722/149686
ISSN
2013 Impact Factor: 3.341
2013 SCImago Journal Rankings: 2.342
ISI Accession Number ID
References

 

Author Affiliations
  1. The University of Hong Kong
  2. Xiangya Hospital of Central-south University
  3. Central South University China
DC FieldValueLanguage
dc.contributor.authorLi, Len_US
dc.contributor.authorZhou, Sen_US
dc.contributor.authorChen, Xen_US
dc.contributor.authorGuo, Len_US
dc.contributor.authorLi, Zen_US
dc.contributor.authorHu, Den_US
dc.contributor.authorLuo, Xen_US
dc.contributor.authorMa, Xen_US
dc.contributor.authorTang, Men_US
dc.contributor.authorYi, Wen_US
dc.contributor.authorTsao, SWen_US
dc.contributor.authorCao, Yen_US
dc.date.accessioned2012-06-26T05:57:06Z-
dc.date.available2012-06-26T05:57:06Z-
dc.date.issued2008en_US
dc.identifier.citationFEBS Letters, 2008, v. 582 n. 5, p. 755-762en_US
dc.identifier.issn0014-5793en_US
dc.identifier.urihttp://hdl.handle.net/10722/149686-
dc.description.abstractThe Epstein-Barr virus (EBV) encoded latent membrane protein 1 (LMP1) plays an important role in the carcinogenesis of nasopharyngeal carcinoma (NPC). The tumor suppressor p53 is an important transcription factor. The mutation of the p53 gene is the frequent alteration in most of tumors, but nearly 100% wild-type p53 gene is found in NPC biopsy. Here, our study testified that SV40 T-antigen transformed nasopharyngeal epithelial cells contained free, wild-type p53. Moreover, LMP1 regulated p53 both at transcriptional and translational level. Furthermore, the mechanism of p53 accumulation mediated by LMP1 from post-translational level-phosphorylation and ubiquitination were determined. Therefore, the effects of EBV LMP1 on p53 may potentially contribute to EBV-associated pathogenesis. © 2008.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/febsleten_US
dc.relation.ispartofFEBS Lettersen_US
dc.subject.meshAntigens, Viral, Tumor - Genetics - Metabolismen_US
dc.subject.meshCell Extractsen_US
dc.subject.meshCell Line, Transformeden_US
dc.subject.meshEpithelial Cells - Cytology - Metabolism - Radiation Effectsen_US
dc.subject.meshGene Expression Regulation - Radiation Effectsen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunoprecipitationen_US
dc.subject.meshNasopharynx - Cytology - Metabolism - Radiation Effectsen_US
dc.subject.meshProtein Biosynthesis - Radiation Effectsen_US
dc.subject.meshProtein Transport - Radiation Effectsen_US
dc.subject.meshRna, Messenger - Genetics - Metabolismen_US
dc.subject.meshRadiation, Ionizingen_US
dc.subject.meshSimian Virus 40en_US
dc.subject.meshTranscription, Genetic - Radiation Effectsen_US
dc.subject.meshTumor Suppressor Protein P53 - Genetics - Metabolismen_US
dc.subject.meshUbiquitination - Radiation Effectsen_US
dc.subject.meshViral Matrix Proteins - Metabolismen_US
dc.titleThe activation of p53 mediated by Epstein-Barr virus latent membrane protein 1 in SV40 large T-antigen transformed cellsen_US
dc.typeArticleen_US
dc.identifier.emailTsao, SW:gswtsao@hkucc.hku.hken_US
dc.identifier.authorityTsao, SW=rp00399en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.febslet.2008.01.031en_US
dc.identifier.pmid18242176en_US
dc.identifier.scopuseid_2-s2.0-39649125193en_US
dc.identifier.hkuros151297-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-39649125193&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume582en_US
dc.identifier.issue5en_US
dc.identifier.spage755en_US
dc.identifier.epage762en_US
dc.identifier.isiWOS:000257670100036-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridLi, L=26662260500en_US
dc.identifier.scopusauthoridZhou, S=16687258000en_US
dc.identifier.scopusauthoridChen, X=8430432900en_US
dc.identifier.scopusauthoridGuo, L=35083512700en_US
dc.identifier.scopusauthoridLi, Z=8219788700en_US
dc.identifier.scopusauthoridHu, D=15764988700en_US
dc.identifier.scopusauthoridLuo, X=15729022900en_US
dc.identifier.scopusauthoridMa, X=7404550202en_US
dc.identifier.scopusauthoridTang, M=54409388100en_US
dc.identifier.scopusauthoridYi, W=36115760400en_US
dc.identifier.scopusauthoridTsao, SW=7102813116en_US
dc.identifier.scopusauthoridCao, Y=7404524499en_US

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