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Article: Activating transcription factor 3 up-regulated by c-Jun NH 2-terminal kinase/c-Jun contributes to apoptosis induced by potassium deprivation in cerebellar granule neurons

TitleActivating transcription factor 3 up-regulated by c-Jun NH 2-terminal kinase/c-Jun contributes to apoptosis induced by potassium deprivation in cerebellar granule neurons
Authors
Issue Date2008
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/neuroscience
Citation
Neuroscience, 2008, v. 151 n. 3, p. 771-779 How to Cite?
AbstractCerebellar granule neurons (CGNs) depend on potassium depolarization for survival and undergo apoptosis when deprived of depolarizing concentration of potassium. Activating transcription factor 3 (ATF3), a stress-inducible protein, belongs to the ATF/CREB family of transcription factors family and is involved in cell growth and apoptosis. However, the role of ATF3 in neuronal apoptosis remains unknown. Here, we showed that ATF3 was up-regulated under potassium deprivation in CGNs, and this induction was preceded by a rapid and sustained activation of c-Jun NH 2-terminal kinase/c-Jun signaling pathway, which plays a fundamental role in neuronal apoptosis. Furthermore, ATF3 up-regulation was abolished by inhibition of JNK or knockdown of c-Jun. Finally, knockdown of ATF3 by RNA interference protected CGNs from potassium deprivation-induced apoptosis. Taken together, our results indicate that ATF3 is a downstream target of JNK/c-Jun pathway and contributes to apoptosis induced by potassium deprivation in rat CGNs. © 2007 IBRO.
Persistent Identifierhttp://hdl.handle.net/10722/149685
ISSN
2015 Impact Factor: 3.231
2015 SCImago Journal Rankings: 1.768
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMei, Yen_US
dc.contributor.authorYuan, Zen_US
dc.contributor.authorSong, Ben_US
dc.contributor.authorLi, Den_US
dc.contributor.authorMa, Cen_US
dc.contributor.authorHu, Cen_US
dc.contributor.authorChing, YPen_US
dc.contributor.authorLi, Men_US
dc.date.accessioned2012-06-26T05:57:05Z-
dc.date.available2012-06-26T05:57:05Z-
dc.date.issued2008en_US
dc.identifier.citationNeuroscience, 2008, v. 151 n. 3, p. 771-779en_US
dc.identifier.issn0306-4522en_US
dc.identifier.urihttp://hdl.handle.net/10722/149685-
dc.description.abstractCerebellar granule neurons (CGNs) depend on potassium depolarization for survival and undergo apoptosis when deprived of depolarizing concentration of potassium. Activating transcription factor 3 (ATF3), a stress-inducible protein, belongs to the ATF/CREB family of transcription factors family and is involved in cell growth and apoptosis. However, the role of ATF3 in neuronal apoptosis remains unknown. Here, we showed that ATF3 was up-regulated under potassium deprivation in CGNs, and this induction was preceded by a rapid and sustained activation of c-Jun NH 2-terminal kinase/c-Jun signaling pathway, which plays a fundamental role in neuronal apoptosis. Furthermore, ATF3 up-regulation was abolished by inhibition of JNK or knockdown of c-Jun. Finally, knockdown of ATF3 by RNA interference protected CGNs from potassium deprivation-induced apoptosis. Taken together, our results indicate that ATF3 is a downstream target of JNK/c-Jun pathway and contributes to apoptosis induced by potassium deprivation in rat CGNs. © 2007 IBRO.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/neuroscienceen_US
dc.relation.ispartofNeuroscienceen_US
dc.rightsNeuroscience. Copyright © Elsevier BV.-
dc.subject.meshActivating Transcription Factor 3 - Genetics - Metabolismen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnimals, Newbornen_US
dc.subject.meshApoptosis - Drug Effects - Physiologyen_US
dc.subject.meshCells, Cultureden_US
dc.subject.meshCerebellum - Cytologyen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshDrug Interactionsen_US
dc.subject.meshEnzyme Inhibitors - Pharmacologyen_US
dc.subject.meshGalactosides - Genetics - Metabolismen_US
dc.subject.meshGreen Fluorescent Proteins - Metabolismen_US
dc.subject.meshJnk Mitogen-Activated Protein Kinases - Genetics - Metabolismen_US
dc.subject.meshLuciferases - Metabolismen_US
dc.subject.meshNeurons - Drug Effects - Physiologyen_US
dc.subject.meshPotassium Chloride - Pharmacologyen_US
dc.subject.meshPotassium Deficiency - Physiopathologyen_US
dc.subject.meshRna, Small Interfering - Pharmacologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshTransfectionen_US
dc.subject.meshUp-Regulation - Drug Effects - Physiologyen_US
dc.titleActivating transcription factor 3 up-regulated by c-Jun NH 2-terminal kinase/c-Jun contributes to apoptosis induced by potassium deprivation in cerebellar granule neuronsen_US
dc.typeArticleen_US
dc.identifier.emailChing, YP:ypching@hku.hken_US
dc.identifier.authorityChing, YP=rp00469en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.neuroscience.2007.10.057en_US
dc.identifier.pmid18178318-
dc.identifier.scopuseid_2-s2.0-38749131195en_US
dc.identifier.hkuros143732-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-38749131195&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume151en_US
dc.identifier.issue3en_US
dc.identifier.spage771en_US
dc.identifier.epage779en_US
dc.identifier.isiWOS:000253188000015-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridMei, Y=7102674721en_US
dc.identifier.scopusauthoridYuan, Z=7401476600en_US
dc.identifier.scopusauthoridSong, B=35234938900en_US
dc.identifier.scopusauthoridLi, D=26324923700en_US
dc.identifier.scopusauthoridMa, C=35080792100en_US
dc.identifier.scopusauthoridHu, C=23099571300en_US
dc.identifier.scopusauthoridChing, YP=7005431277en_US
dc.identifier.scopusauthoridLi, M=12765700400en_US

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