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Article: Differential expressions and roles of hypoxia-inducible factor-1α, -2α and -3α in the rat carotid body during chronic and intermittent hypoxia

TitleDifferential expressions and roles of hypoxia-inducible factor-1α, -2α and -3α in the rat carotid body during chronic and intermittent hypoxia
Authors
KeywordsCarotid body
Hypoxia-inducible factor
Intermittent hypoxia
Sleep apnea
Issue Date2008
PublisherHistology and Histopathology. The Journal's web site is located at http://www.hh.um.es
Citation
Histology And Histopathology, 2008, v. 23 n. 3, p. 271-280 How to Cite?
AbstractSummary. The HIF-1α expression in the carotid body (CB) is central to the transcriptional regulation of the CB structural and functional changes in chronic hypoxia (CH). The CB plays pathogenic roles in cardiovascular morbidity in patients with sleep-disordered breathing; yet, the expression and role of HIF-α subtypes in intermittent hypoxia (IH), resembling recurrent episodic apnea, are unclear. We hypothesized a divergent role of HIF-α subtypes, regulated by differential expression in the CB response to IH. A time-course analysis of the CB volume, and expression profiles of the HIF-1α, -2α, -3α and HIF-regulated gene products, including vascular endothelial growth factor (VEGF), endothelin-1 (ET-1), and tyrosine hydroxylase (TH), showed a significant difference in the lack of increase in the rat CB volume, HIF-1α and VEGF expression during IH, despite an increase in the mRNA level of HIF-1α and the prominent increase of volume and expression in the CH group. In contrast, there were increased CB expressions of HIF-2α and -3α, and also ET-1 and TH in both IH and CH groups. Results demonstrated a significant role played by HIF-2α and -3α in the CB response to IH, which could be complementary to the expression and role of HIF-1α under hypoxic conditions. This differential regulation of the HIF-α subtypes and pathways could account for the morphological and neurochemical discrepancy in the CB responses to IH and CH.
Persistent Identifierhttp://hdl.handle.net/10722/149684
ISSN
2015 Impact Factor: 1.875
2015 SCImago Journal Rankings: 0.805
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLam, SYen_HK
dc.contributor.authorTipoe, GLen_HK
dc.contributor.authorLiong, ECen_HK
dc.contributor.authorFung, MLen_HK
dc.date.accessioned2012-06-26T05:57:04Z-
dc.date.available2012-06-26T05:57:04Z-
dc.date.issued2008en_HK
dc.identifier.citationHistology And Histopathology, 2008, v. 23 n. 3, p. 271-280en_HK
dc.identifier.issn0213-3911en_HK
dc.identifier.urihttp://hdl.handle.net/10722/149684-
dc.description.abstractSummary. The HIF-1α expression in the carotid body (CB) is central to the transcriptional regulation of the CB structural and functional changes in chronic hypoxia (CH). The CB plays pathogenic roles in cardiovascular morbidity in patients with sleep-disordered breathing; yet, the expression and role of HIF-α subtypes in intermittent hypoxia (IH), resembling recurrent episodic apnea, are unclear. We hypothesized a divergent role of HIF-α subtypes, regulated by differential expression in the CB response to IH. A time-course analysis of the CB volume, and expression profiles of the HIF-1α, -2α, -3α and HIF-regulated gene products, including vascular endothelial growth factor (VEGF), endothelin-1 (ET-1), and tyrosine hydroxylase (TH), showed a significant difference in the lack of increase in the rat CB volume, HIF-1α and VEGF expression during IH, despite an increase in the mRNA level of HIF-1α and the prominent increase of volume and expression in the CH group. In contrast, there were increased CB expressions of HIF-2α and -3α, and also ET-1 and TH in both IH and CH groups. Results demonstrated a significant role played by HIF-2α and -3α in the CB response to IH, which could be complementary to the expression and role of HIF-1α under hypoxic conditions. This differential regulation of the HIF-α subtypes and pathways could account for the morphological and neurochemical discrepancy in the CB responses to IH and CH.en_HK
dc.languageengen_US
dc.publisherHistology and Histopathology. The Journal's web site is located at http://www.hh.um.esen_HK
dc.relation.ispartofHistology and Histopathologyen_HK
dc.subjectCarotid bodyen_HK
dc.subjectHypoxia-inducible factoren_HK
dc.subjectIntermittent hypoxiaen_HK
dc.subjectSleep apneaen_HK
dc.subject.meshAnimalsen_US
dc.subject.meshAnoxia - Metabolism - Pathologyen_US
dc.subject.meshBasic Helix-Loop-Helix Transcription Factors - Genetics - Metabolismen_US
dc.subject.meshCarotid Body - Metabolism - Pathologyen_US
dc.subject.meshChemoreceptor Cells - Physiologyen_US
dc.subject.meshDisease Models, Animalen_US
dc.subject.meshEndothelin-1 - Genetics - Metabolismen_US
dc.subject.meshHypoxia-Inducible Factor 1, Alpha Subunit - Genetics - Metabolismen_US
dc.subject.meshMaleen_US
dc.subject.meshRna, Messenger - Genetics - Metabolismen_US
dc.subject.meshRandom Allocationen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshSleep Apnea Syndromes - Metabolism - Pathology - Physiopathologyen_US
dc.subject.meshTime Factorsen_US
dc.subject.meshTranscription Factors - Genetics - Metabolismen_US
dc.subject.meshTyrosine 3-Monooxygenase - Genetics - Metabolismen_US
dc.subject.meshVascular Endothelial Growth Factor A - Genetics - Metabolismen_US
dc.titleDifferential expressions and roles of hypoxia-inducible factor-1α, -2α and -3α in the rat carotid body during chronic and intermittent hypoxiaen_HK
dc.typeArticleen_HK
dc.identifier.emailTipoe, GL: tgeorge@hkucc.hku.hken_HK
dc.identifier.emailFung, ML: fungml@hkucc.hku.hken_HK
dc.identifier.emailLam, SSY: lam.sy.sylvia@gmail.com-
dc.identifier.emailLiong, EC: eclionga@HKUCC.hku.hk-
dc.identifier.authorityTipoe, GL=rp00371en_HK
dc.identifier.authorityFung, ML=rp00433en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid18072084-
dc.identifier.scopuseid_2-s2.0-84863989372en_HK
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84863989372&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume23en_HK
dc.identifier.issue3en_HK
dc.identifier.spage271en_HK
dc.identifier.epage280en_HK
dc.identifier.isiWOS:000251459700003-
dc.publisher.placeSpainen_HK
dc.identifier.scopusauthoridLam, SY=7402279518en_HK
dc.identifier.scopusauthoridTipoe, GL=7003550610en_HK
dc.identifier.scopusauthoridLiong, EC=6602732210en_HK
dc.identifier.scopusauthoridFung, ML=7101955092en_HK

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