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Article: Antagonizing β-amyloid peptide neurotoxicity of the anti-aging fungus Ganoderma lucidum

TitleAntagonizing β-amyloid peptide neurotoxicity of the anti-aging fungus Ganoderma lucidum
Authors
Issue Date2008
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainres
Citation
Brain Research, 2008, v. 1190 n. 1, p. 215-224 How to Cite?
AbstractGanoderma lucidum (Leyss. ex Fr.) Karst. (Lingzhi) is a medicinal fungus used clinically in many Asian countries to promote health and longevity. Synaptic degeneration is another key mode of neurodegeneration in Alzheimer's disease (AD). Recent studies have shown the loss of synaptic density proteins in each individual neuron during the progression of AD. It was recently reported that β-amyloid (Aβ) could cause synaptic dysfunction and contribute to AD pathology. In this study, we reported that aqueous extract of G. lucidum significantly attenuated Aβ-induced synaptotoxicity by preserving the synaptic density protein, synaptophysin. In addition, G. lucidum aqueous extract antagonized Aβ-triggered DEVD cleavage activities in a dose-dependent manner. Further studies elucidated that phosphorylation of c-Jun N-terminal kinase, c-Jun, and p38 MAP kinase was attenuated by G. lucidum in Aβ-stressed neurons. Taken together, the results prove a hypothesis that anti-aging G. lucidum can prevent harmful effects of the exterminating toxin Aβ in AD. © 2007 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/149682
ISSN
2015 Impact Factor: 2.561
2015 SCImago Journal Rankings: 1.351
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLai, CSWen_US
dc.contributor.authorYu, MSen_US
dc.contributor.authorYuen, WHen_US
dc.contributor.authorSo, KFen_US
dc.contributor.authorZee, SYen_US
dc.contributor.authorChang, RCCen_US
dc.date.accessioned2012-06-26T05:57:03Z-
dc.date.available2012-06-26T05:57:03Z-
dc.date.issued2008en_US
dc.identifier.citationBrain Research, 2008, v. 1190 n. 1, p. 215-224en_US
dc.identifier.issn0006-8993en_US
dc.identifier.urihttp://hdl.handle.net/10722/149682-
dc.description.abstractGanoderma lucidum (Leyss. ex Fr.) Karst. (Lingzhi) is a medicinal fungus used clinically in many Asian countries to promote health and longevity. Synaptic degeneration is another key mode of neurodegeneration in Alzheimer's disease (AD). Recent studies have shown the loss of synaptic density proteins in each individual neuron during the progression of AD. It was recently reported that β-amyloid (Aβ) could cause synaptic dysfunction and contribute to AD pathology. In this study, we reported that aqueous extract of G. lucidum significantly attenuated Aβ-induced synaptotoxicity by preserving the synaptic density protein, synaptophysin. In addition, G. lucidum aqueous extract antagonized Aβ-triggered DEVD cleavage activities in a dose-dependent manner. Further studies elucidated that phosphorylation of c-Jun N-terminal kinase, c-Jun, and p38 MAP kinase was attenuated by G. lucidum in Aβ-stressed neurons. Taken together, the results prove a hypothesis that anti-aging G. lucidum can prevent harmful effects of the exterminating toxin Aβ in AD. © 2007 Elsevier B.V. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainresen_US
dc.relation.ispartofBrain Researchen_US
dc.subject.meshAlzheimer Disease - Metabolism - Prevention & Controlen_US
dc.subject.meshAmyloid Beta-Peptides - Drug Effects - Metabolismen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCells, Cultureden_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshDrugs, Chinese Herbal - Pharmacologyen_US
dc.subject.meshMedicine, East Asian Traditionalen_US
dc.subject.meshNeurites - Drug Effects - Metabolism - Pathologyen_US
dc.subject.meshNeurons - Drug Effects - Metabolism - Pathologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshReishi - Chemistryen_US
dc.subject.meshSynapses - Drug Effects - Metabolismen_US
dc.subject.meshSynaptophysin - Drug Effects - Metabolismen_US
dc.titleAntagonizing β-amyloid peptide neurotoxicity of the anti-aging fungus Ganoderma lucidumen_US
dc.typeArticleen_US
dc.identifier.emailSo, KF:hrmaskf@hkucc.hku.hken_US
dc.identifier.emailChang, RCC:rccchang@hkucc.hku.hken_US
dc.identifier.authoritySo, KF=rp00329en_US
dc.identifier.authorityChang, RCC=rp00470en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.brainres.2007.10.103en_US
dc.identifier.pmid18083148-
dc.identifier.scopuseid_2-s2.0-37549023851en_US
dc.identifier.hkuros141964-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-37549023851&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume1190en_US
dc.identifier.issue1en_US
dc.identifier.spage215en_US
dc.identifier.epage224en_US
dc.identifier.isiWOS:000253256500022-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridLai, CSW=26022547000en_US
dc.identifier.scopusauthoridYu, MS=35346047600en_US
dc.identifier.scopusauthoridYuen, WH=7102761282en_US
dc.identifier.scopusauthoridSo, KF=34668391300en_US
dc.identifier.scopusauthoridZee, SY=7004001733en_US
dc.identifier.scopusauthoridChang, RCC=7403713410en_US

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