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Article: The 'kiss of death' by dendritic cells to cancer cells

TitleThe 'kiss of death' by dendritic cells to cancer cells
Authors
Issue Date2008
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/cdd
Citation
Cell Death And Differentiation, 2008, v. 15 n. 1, p. 58-69 How to Cite?
AbstractDendritic cells (DCs) are professional antigen-presenting cells (APCs) specialized in the stimulation of naïve T lymphocytes, which are key components of antiviral and antitumor immunity. DCs are 'sentinels' of the immune system endowed with the mission to (1) sense invading pathogens as well as any form of tissue distress and (2) alert the effectors of the immune response. They represent a very heterogeneous population including subsets characterized by their anatomical locations and specific missions. Beyond their unique APC features, DCs exhibit a large array of effector functions that play critical roles in the induction and regulation of the cell-mediated as well as humoral immune responses. In the course of the antitumor immune response, DCs are unique in engulfing tumor cells killed by natural killer (NK) cells and cross-presenting tumor-associated antigens to cytotoxic T lymphocytes (CTLs). However, while DCs mediate antitumor immune responses by stimulating tumor-specific CTLs and NK cells, direct tumoricidal mechanisms have been recently evoked. This review addresses the other face of DCs to directly deliver apoptotic signals to stressed cells, their role in tumor cell death, and its implication in the design of DC-based cancer immunotherapies.
Persistent Identifierhttp://hdl.handle.net/10722/149681
ISSN
2015 Impact Factor: 8.218
2015 SCImago Journal Rankings: 4.219
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, CWen_US
dc.contributor.authorHousseau, Fen_US
dc.date.accessioned2012-06-26T05:57:03Z-
dc.date.available2012-06-26T05:57:03Z-
dc.date.issued2008en_US
dc.identifier.citationCell Death And Differentiation, 2008, v. 15 n. 1, p. 58-69en_US
dc.identifier.issn1350-9047en_US
dc.identifier.urihttp://hdl.handle.net/10722/149681-
dc.description.abstractDendritic cells (DCs) are professional antigen-presenting cells (APCs) specialized in the stimulation of naïve T lymphocytes, which are key components of antiviral and antitumor immunity. DCs are 'sentinels' of the immune system endowed with the mission to (1) sense invading pathogens as well as any form of tissue distress and (2) alert the effectors of the immune response. They represent a very heterogeneous population including subsets characterized by their anatomical locations and specific missions. Beyond their unique APC features, DCs exhibit a large array of effector functions that play critical roles in the induction and regulation of the cell-mediated as well as humoral immune responses. In the course of the antitumor immune response, DCs are unique in engulfing tumor cells killed by natural killer (NK) cells and cross-presenting tumor-associated antigens to cytotoxic T lymphocytes (CTLs). However, while DCs mediate antitumor immune responses by stimulating tumor-specific CTLs and NK cells, direct tumoricidal mechanisms have been recently evoked. This review addresses the other face of DCs to directly deliver apoptotic signals to stressed cells, their role in tumor cell death, and its implication in the design of DC-based cancer immunotherapies.en_US
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/cdden_US
dc.relation.ispartofCell Death and Differentiationen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntigens, Neoplasm - Immunologyen_US
dc.subject.meshApoptosisen_US
dc.subject.meshCytotoxicity, Immunologicen_US
dc.subject.meshDendritic Cells - Immunology - Metabolismen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunity, Innateen_US
dc.subject.meshImmunologic Surveillanceen_US
dc.subject.meshImmunotherapyen_US
dc.subject.meshKiller Cells, Natural - Immunologyen_US
dc.subject.meshLigandsen_US
dc.subject.meshNeoplasms - Immunology - Pathology - Physiopathologyen_US
dc.subject.meshReceptors, Cell Surface - Immunologyen_US
dc.subject.meshSignal Transductionen_US
dc.subject.meshT-Lymphocytes, Cytotoxic - Immunologyen_US
dc.subject.meshToll-Like Receptors - Immunologyen_US
dc.titleThe 'kiss of death' by dendritic cells to cancer cellsen_US
dc.typeArticleen_US
dc.identifier.emailChan, CW:camchan@hku.hken_US
dc.identifier.authorityChan, CW=rp01311en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1038/sj.cdd.4402235en_US
dc.identifier.pmid17948029-
dc.identifier.scopuseid_2-s2.0-37349115591en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-37349115591&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume15en_US
dc.identifier.issue1en_US
dc.identifier.spage58en_US
dc.identifier.epage69en_US
dc.identifier.isiWOS:000251820900008-
dc.publisher.placeUnited Kingdomen_US
dc.identifier.scopusauthoridChan, CW=12240386600en_US
dc.identifier.scopusauthoridHousseau, F=6603256765en_US
dc.identifier.citeulike1795332-

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