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Article: Reknitting the injured spinal cord by self-assembling peptide nanofiber scaffold

TitleReknitting the injured spinal cord by self-assembling peptide nanofiber scaffold
Authors
KeywordsNanofiber scaffold
Neural progenitor cell
Schwann cell
Self-assembling peptide
Spinal cord injury
Issue Date2007
PublisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/nanomed
Citation
Nanomedicine: Nanotechnology, Biology, And Medicine, 2007, v. 3 n. 4, p. 311-321 How to Cite?
AbstractIn traumatic spinal cord injury, loss of neurological function is due to the inability of damaged axons to regenerate across large, cystic cavities. It has recently been demonstrated that a self-assembled nanofiber scaffold (SAPNS) could repair the injured optical pathway and restore visual function. To demonstrate the possibility of using it to repair spinal cord injury, transplanted neural progenitor cells and Schwann cells were isolated from green fluorescent protein-transgenic rats, cultured within SAPNS, and then transplanted into the transected dorsal column of spinal cord of rats. Here we report the use of SAPNS to bridge the injured spinal cord of rats, demonstrating robust migration of host cells, growth of blood vessels, and axons into the scaffolds, indicating that SAPNS provides a true three-dimensional environment for the migration of living cells. © 2007 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/149680
ISSN
2015 Impact Factor: 5.671
2015 SCImago Journal Rankings: 1.886
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorGuo, Jen_HK
dc.contributor.authorSu, Hen_HK
dc.contributor.authorZeng, Yen_HK
dc.contributor.authorLiang, YXen_HK
dc.contributor.authorWong, WMen_HK
dc.contributor.authorEllisBehnke, RGen_HK
dc.contributor.authorSo, KFen_HK
dc.contributor.authorWu, Wen_HK
dc.date.accessioned2012-06-26T05:57:02Z-
dc.date.available2012-06-26T05:57:02Z-
dc.date.issued2007en_HK
dc.identifier.citationNanomedicine: Nanotechnology, Biology, And Medicine, 2007, v. 3 n. 4, p. 311-321en_HK
dc.identifier.issn1549-9634en_HK
dc.identifier.urihttp://hdl.handle.net/10722/149680-
dc.description.abstractIn traumatic spinal cord injury, loss of neurological function is due to the inability of damaged axons to regenerate across large, cystic cavities. It has recently been demonstrated that a self-assembled nanofiber scaffold (SAPNS) could repair the injured optical pathway and restore visual function. To demonstrate the possibility of using it to repair spinal cord injury, transplanted neural progenitor cells and Schwann cells were isolated from green fluorescent protein-transgenic rats, cultured within SAPNS, and then transplanted into the transected dorsal column of spinal cord of rats. Here we report the use of SAPNS to bridge the injured spinal cord of rats, demonstrating robust migration of host cells, growth of blood vessels, and axons into the scaffolds, indicating that SAPNS provides a true three-dimensional environment for the migration of living cells. © 2007 Elsevier Inc. All rights reserved.en_HK
dc.languageengen_US
dc.publisherElsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/nanomeden_HK
dc.relation.ispartofNanomedicine: Nanotechnology, Biology, and Medicineen_HK
dc.subjectNanofiber scaffolden_HK
dc.subjectNeural progenitor cellen_HK
dc.subjectSchwann cellen_HK
dc.subjectSelf-assembling peptideen_HK
dc.subjectSpinal cord injuryen_HK
dc.subject.meshAnimalsen_US
dc.subject.meshFemaleen_US
dc.subject.meshGuided Tissue Regeneration - Instrumentation - Methodsen_US
dc.subject.meshNanostructures - Therapeutic Use - Ultrastructureen_US
dc.subject.meshNerve Regenerationen_US
dc.subject.meshNeurons - Pathology - Transplantationen_US
dc.subject.meshPeptides - Therapeutic Useen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshSpinal Cord Injuries - Pathology - Surgeryen_US
dc.subject.meshTreatment Outcomeen_US
dc.titleReknitting the injured spinal cord by self-assembling peptide nanofiber scaffolden_HK
dc.typeArticleen_HK
dc.identifier.emailLiang, YX: yxliang@hkucc.hku.hken_HK
dc.identifier.emailEllisBehnke, RG: rutledg@mit.eduen_HK
dc.identifier.emailSo, KF: hrmaskf@hku.hken_HK
dc.identifier.emailWu, W: wtwu@hkucc.hku.hken_HK
dc.identifier.authorityLiang, YX=rp00510en_HK
dc.identifier.authorityEllisBehnke, RG=rp00252en_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.identifier.authorityWu, W=rp00419en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.nano.2007.09.003en_HK
dc.identifier.pmid17964861-
dc.identifier.scopuseid_2-s2.0-36749028224en_HK
dc.identifier.hkuros138859-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-36749028224&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume3en_HK
dc.identifier.issue4en_HK
dc.identifier.spage311en_HK
dc.identifier.epage321en_HK
dc.identifier.eissn1549-9642-
dc.identifier.isiWOS:000251735900009-
dc.publisher.placeUnited Statesen_HK
dc.identifier.scopusauthoridGuo, J=7404488603en_HK
dc.identifier.scopusauthoridSu, H=16317750200en_HK
dc.identifier.scopusauthoridZeng, Y=8236229300en_HK
dc.identifier.scopusauthoridLiang, YX=55479398500en_HK
dc.identifier.scopusauthoridWong, WM=7403972413en_HK
dc.identifier.scopusauthoridEllisBehnke, RG=8548055200en_HK
dc.identifier.scopusauthoridSo, KF=34668391300en_HK
dc.identifier.scopusauthoridWu, W=7407081122en_HK
dc.identifier.citeulike5780371-

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