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- Publisher Website: 10.1016/j.nano.2007.09.003
- Scopus: eid_2-s2.0-36749028224
- PMID: 17964861
- WOS: WOS:000251735900009
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Article: Reknitting the injured spinal cord by self-assembling peptide nanofiber scaffold
Title | Reknitting the injured spinal cord by self-assembling peptide nanofiber scaffold |
---|---|
Authors | |
Keywords | Nanofiber scaffold Neural progenitor cell Schwann cell Self-assembling peptide Spinal cord injury |
Issue Date | 2007 |
Publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/nanomed |
Citation | Nanomedicine: Nanotechnology, Biology, And Medicine, 2007, v. 3 n. 4, p. 311-321 How to Cite? |
Abstract | In traumatic spinal cord injury, loss of neurological function is due to the inability of damaged axons to regenerate across large, cystic cavities. It has recently been demonstrated that a self-assembled nanofiber scaffold (SAPNS) could repair the injured optical pathway and restore visual function. To demonstrate the possibility of using it to repair spinal cord injury, transplanted neural progenitor cells and Schwann cells were isolated from green fluorescent protein-transgenic rats, cultured within SAPNS, and then transplanted into the transected dorsal column of spinal cord of rats. Here we report the use of SAPNS to bridge the injured spinal cord of rats, demonstrating robust migration of host cells, growth of blood vessels, and axons into the scaffolds, indicating that SAPNS provides a true three-dimensional environment for the migration of living cells. © 2007 Elsevier Inc. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/149680 |
ISSN | 2023 Impact Factor: 4.2 2023 SCImago Journal Rankings: 0.863 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Guo, J | en_HK |
dc.contributor.author | Su, H | en_HK |
dc.contributor.author | Zeng, Y | en_HK |
dc.contributor.author | Liang, YX | en_HK |
dc.contributor.author | Wong, WM | en_HK |
dc.contributor.author | EllisBehnke, RG | en_HK |
dc.contributor.author | So, KF | en_HK |
dc.contributor.author | Wu, W | en_HK |
dc.date.accessioned | 2012-06-26T05:57:02Z | - |
dc.date.available | 2012-06-26T05:57:02Z | - |
dc.date.issued | 2007 | en_HK |
dc.identifier.citation | Nanomedicine: Nanotechnology, Biology, And Medicine, 2007, v. 3 n. 4, p. 311-321 | en_HK |
dc.identifier.issn | 1549-9634 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/149680 | - |
dc.description.abstract | In traumatic spinal cord injury, loss of neurological function is due to the inability of damaged axons to regenerate across large, cystic cavities. It has recently been demonstrated that a self-assembled nanofiber scaffold (SAPNS) could repair the injured optical pathway and restore visual function. To demonstrate the possibility of using it to repair spinal cord injury, transplanted neural progenitor cells and Schwann cells were isolated from green fluorescent protein-transgenic rats, cultured within SAPNS, and then transplanted into the transected dorsal column of spinal cord of rats. Here we report the use of SAPNS to bridge the injured spinal cord of rats, demonstrating robust migration of host cells, growth of blood vessels, and axons into the scaffolds, indicating that SAPNS provides a true three-dimensional environment for the migration of living cells. © 2007 Elsevier Inc. All rights reserved. | en_HK |
dc.language | eng | en_US |
dc.publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/nanomed | en_HK |
dc.relation.ispartof | Nanomedicine: Nanotechnology, Biology, and Medicine | en_HK |
dc.subject | Nanofiber scaffold | en_HK |
dc.subject | Neural progenitor cell | en_HK |
dc.subject | Schwann cell | en_HK |
dc.subject | Self-assembling peptide | en_HK |
dc.subject | Spinal cord injury | en_HK |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Guided Tissue Regeneration - Instrumentation - Methods | en_US |
dc.subject.mesh | Nanostructures - Therapeutic Use - Ultrastructure | en_US |
dc.subject.mesh | Nerve Regeneration | en_US |
dc.subject.mesh | Neurons - Pathology - Transplantation | en_US |
dc.subject.mesh | Peptides - Therapeutic Use | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Rats, Sprague-Dawley | en_US |
dc.subject.mesh | Spinal Cord Injuries - Pathology - Surgery | en_US |
dc.subject.mesh | Treatment Outcome | en_US |
dc.title | Reknitting the injured spinal cord by self-assembling peptide nanofiber scaffold | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Liang, YX: yxliang@hkucc.hku.hk | en_HK |
dc.identifier.email | EllisBehnke, RG: rutledg@mit.edu | en_HK |
dc.identifier.email | So, KF: hrmaskf@hku.hk | en_HK |
dc.identifier.email | Wu, W: wtwu@hkucc.hku.hk | en_HK |
dc.identifier.authority | Liang, YX=rp00510 | en_HK |
dc.identifier.authority | EllisBehnke, RG=rp00252 | en_HK |
dc.identifier.authority | So, KF=rp00329 | en_HK |
dc.identifier.authority | Wu, W=rp00419 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/j.nano.2007.09.003 | en_HK |
dc.identifier.pmid | 17964861 | - |
dc.identifier.scopus | eid_2-s2.0-36749028224 | en_HK |
dc.identifier.hkuros | 138859 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-36749028224&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 3 | en_HK |
dc.identifier.issue | 4 | en_HK |
dc.identifier.spage | 311 | en_HK |
dc.identifier.epage | 321 | en_HK |
dc.identifier.eissn | 1549-9642 | - |
dc.identifier.isi | WOS:000251735900009 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Guo, J=7404488603 | en_HK |
dc.identifier.scopusauthorid | Su, H=16317750200 | en_HK |
dc.identifier.scopusauthorid | Zeng, Y=8236229300 | en_HK |
dc.identifier.scopusauthorid | Liang, YX=55479398500 | en_HK |
dc.identifier.scopusauthorid | Wong, WM=7403972413 | en_HK |
dc.identifier.scopusauthorid | EllisBehnke, RG=8548055200 | en_HK |
dc.identifier.scopusauthorid | So, KF=34668391300 | en_HK |
dc.identifier.scopusauthorid | Wu, W=7407081122 | en_HK |
dc.identifier.citeulike | 5780371 | - |
dc.identifier.issnl | 1549-9634 | - |