Article: Latent membrane protein 1 of Epstein-Barr virus regulates p53 phosphorylation through MAP kinases

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TitleLatent membrane protein 1 of Epstein-Barr virus regulates p53 phosphorylation through MAP kinases
AuthorsLi, L2
Guo, L2
Tao, Y2
Zhou, S2
Wang, Z2
Luo, W2
Hu, D2
Li, Z2
Xiao, L2
Tang, M2
Yi, W2
Tsao, SW1
Cao, Y2
Issue Date2007
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet
CitationCancer Letters, 2007, v. 255 n. 2, p. 219-231 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.canlet.2007.04.014
AbstractThe Epstein-Barr virus (EBV) encoded latent membrane protein 1 (LMP1), an oncogenic protein, plays an important role in the carcinogenesis of nasopharyngeal carcinoma (NPC). Phosphorylation of p53 protein is likely to play the key role in regulating its activity. p53 protein accumulates but mutation of p53 gene is not common in NPC. The molecular mechanisms of p53 augmentation have not been completely elucidated. Here, the role of MAP kinases in the phosphorylation of p53 modulated by LMP1 was determined. p53 could be activated and phosphorylated clearly at Ser15, Ser20, Ser392, and Thr81 modulated by LMP1. Furthermore, LMP1-induced phosphorylation of p53 at Ser15 was directly by ERKs; at Ser20 and Thr81 by JNK, at Ser 15 and Ser392 by p38 kinase. The phosphorylation of p53 was associated with its transcriptional activity and stability modulated by LMP1. These results strongly suggest that MAP kinases have a direct role in LMP1-induced phosphorylation of p53 at multiple sites, which provide a novel view for us to understand the mechanism of the activation of p53 in the carcinogenesis of nasopharyngeal carcinoma. © 2007 Elsevier Ireland Ltd. All rights reserved.
ISSN0304-3835
2011 Impact Factor: 4.238
2011 SCImago Journal Rankings: 0.494
DOIhttp://dx.doi.org/10.1016/j.canlet.2007.04.014
ISI Accession Number IDWOS:000249676700006
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorLi, L
dc.contributor.authorGuo, L
dc.contributor.authorTao, Y
dc.contributor.authorZhou, S
dc.contributor.authorWang, Z
dc.contributor.authorLuo, W
dc.contributor.authorHu, D
dc.contributor.authorLi, Z
dc.contributor.authorXiao, L
dc.contributor.authorTang, M
dc.contributor.authorYi, W
dc.contributor.authorTsao, SW
dc.contributor.authorCao, Y
dc.date.accessioned2012-06-26T05:56:54Z
dc.date.available2012-06-26T05:56:54Z
dc.date.issued2007
dc.description.abstractThe Epstein-Barr virus (EBV) encoded latent membrane protein 1 (LMP1), an oncogenic protein, plays an important role in the carcinogenesis of nasopharyngeal carcinoma (NPC). Phosphorylation of p53 protein is likely to play the key role in regulating its activity. p53 protein accumulates but mutation of p53 gene is not common in NPC. The molecular mechanisms of p53 augmentation have not been completely elucidated. Here, the role of MAP kinases in the phosphorylation of p53 modulated by LMP1 was determined. p53 could be activated and phosphorylated clearly at Ser15, Ser20, Ser392, and Thr81 modulated by LMP1. Furthermore, LMP1-induced phosphorylation of p53 at Ser15 was directly by ERKs; at Ser20 and Thr81 by JNK, at Ser 15 and Ser392 by p38 kinase. The phosphorylation of p53 was associated with its transcriptional activity and stability modulated by LMP1. These results strongly suggest that MAP kinases have a direct role in LMP1-induced phosphorylation of p53 at multiple sites, which provide a novel view for us to understand the mechanism of the activation of p53 in the carcinogenesis of nasopharyngeal carcinoma. © 2007 Elsevier Ireland Ltd. All rights reserved.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationCancer Letters, 2007, v. 255 n. 2, p. 219-231 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.canlet.2007.04.014
dc.identifier.doihttp://dx.doi.org/10.1016/j.canlet.2007.04.014
dc.identifier.epage231
dc.identifier.isiWOS:000249676700006
dc.identifier.issn0304-3835
2011 Impact Factor: 4.238
2011 SCImago Journal Rankings: 0.494
dc.identifier.issue2
dc.identifier.pmid17582679
dc.identifier.scopuseid_2-s2.0-34547965826
dc.identifier.spage219
dc.identifier.urihttp://hdl.handle.net/10722/149674
dc.identifier.volume255
dc.languageeng
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/canlet
dc.publisher.placeIreland
dc.relation.ispartofCancer Letters
dc.relation.referencesReferences in Scopus
dc.subject.meshCell Line, Tumor
dc.subject.meshEpstein-Barr Virus Infections - Metabolism
dc.subject.meshHerpesvirus 4, Human - Metabolism
dc.subject.meshHumans
dc.subject.meshMitogen-Activated Protein Kinases - Physiology
dc.subject.meshNasopharyngeal Neoplasms - Virology
dc.subject.meshPhosphorylation
dc.subject.meshSerine - Metabolism
dc.subject.meshThreonine - Metabolism
dc.subject.meshTumor Suppressor Protein P53 - Metabolism
dc.subject.meshViral Matrix Proteins - Metabolism
dc.titleLatent membrane protein 1 of Epstein-Barr virus regulates p53 phosphorylation through MAP kinases
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong
  2. Central South University China