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Article: Modulation of the suppressive effect of corticosterone on adult rat hippocampal cell proliferation by paroxetine

TitleModulation of the suppressive effect of corticosterone on adult rat hippocampal cell proliferation by paroxetine
帕罗西汀对皮质酮抑制成年大鼠海马细胞增殖的调制作用
Authors
KeywordsBromodeoxyuridine
Cell proliferation
Corticosterone
Hippocampus
Neurogenesis
Paroxetine
Issue Date2007
PublisherScience Press (科學出版社) with Springer. The Journal's web site is located at http://www.neurosci.cn/
Citation
Neuroscience Bulletin, 2007, v. 23 n. 3, p. 131-136 How to Cite?
神经科学通报(英文版), 2007, v. 23 n. 3, p. 131-136 How to Cite?
AbstractObjective: The literature has shown that cognitive and emotional changes may occur after chronic treatment with glucocorticoids. This might be caused by the suppressive effect of glucocorticoids on hippocampal neurogenesis and cell proliferation. Paroxetine, a selective serotonin reuptake transporter, is a commonly used antidepressant for alleviation of signs and symptoms of clinical depression. It was discovered to promote hippocampal neurogenesis in the past few years and we wanted to investigate its interaction with glucocorticoid in this study. Methods: Adult rats were given vehicle, corticosterone, paroxetine, or both corticosterone and paroxetine for 14 d. Cell proliferation in the dentate gyrus was quantified using 5-bromo-2-deoxyuridine (BrdU) immunohistochemistry. Results: The corticosterone treatment suppressed while paroxetine treatment increased hippocampal cell proliferation. More importantly, paroxetine treatment could reverse the suppressive effect of corticosterone on hippocampal cell proliferation. Conclusion: This may have clinic application in preventing hippocampal damage after glucocorticoid treatment.
目的 慢性糖皮质激素治疗可能导致认知和情感变化,这或许是由于糖皮质激素对海马神经发生及细胞增殖的抑制作用造成.帕罗西汀是一种选择性血清素重摄取抑制剂,临床常用作减轻抑郁症状,近几年来发现它能促进海马神经发生.本研究探讨帕罗西汀与慢性糖皮质激素的相互作用.方法 成年大鼠被分成四组,分别给予芝麻油、皮质酮、帕罗西汀或皮质酮和帕罗西汀十四天.溴脱氧尿嘧啶核苷(5-bromo-2-deoxyuridine,BrdU)免疫组化法被用于定量齿状回的细胞增殖.结果 皮质酮抑制了海马的细胞增殖,帕罗西汀增加了海马的细胞增殖.同时给药组还显示帕罗西汀能逆转皮质酮的抑制作用.结论 本研究结果对防止海马在类固醇治疗以后的损害或许有临床意义.
Persistent Identifierhttp://hdl.handle.net/10722/149672
ISSN
2015 Impact Factor: 2.322
2015 SCImago Journal Rankings: 1.053
References

 

DC FieldValueLanguage
dc.contributor.authorQiu, Gen_HK
dc.contributor.authorHelmeste, DMen_HK
dc.contributor.authorSamaranayake, ANen_HK
dc.contributor.authorLau, WMen_HK
dc.contributor.authorLee, TMCen_HK
dc.contributor.authorTang, SWen_HK
dc.contributor.authorSo, KFen_HK
dc.date.accessioned2012-06-26T05:56:50Z-
dc.date.available2012-06-26T05:56:50Z-
dc.date.issued2007en_HK
dc.identifier.citationNeuroscience Bulletin, 2007, v. 23 n. 3, p. 131-136en_HK
dc.identifier.citation神经科学通报(英文版), 2007, v. 23 n. 3, p. 131-136-
dc.identifier.issn1673-7067en_HK
dc.identifier.urihttp://hdl.handle.net/10722/149672-
dc.description.abstractObjective: The literature has shown that cognitive and emotional changes may occur after chronic treatment with glucocorticoids. This might be caused by the suppressive effect of glucocorticoids on hippocampal neurogenesis and cell proliferation. Paroxetine, a selective serotonin reuptake transporter, is a commonly used antidepressant for alleviation of signs and symptoms of clinical depression. It was discovered to promote hippocampal neurogenesis in the past few years and we wanted to investigate its interaction with glucocorticoid in this study. Methods: Adult rats were given vehicle, corticosterone, paroxetine, or both corticosterone and paroxetine for 14 d. Cell proliferation in the dentate gyrus was quantified using 5-bromo-2-deoxyuridine (BrdU) immunohistochemistry. Results: The corticosterone treatment suppressed while paroxetine treatment increased hippocampal cell proliferation. More importantly, paroxetine treatment could reverse the suppressive effect of corticosterone on hippocampal cell proliferation. Conclusion: This may have clinic application in preventing hippocampal damage after glucocorticoid treatment.en_HK
dc.description.abstract目的 慢性糖皮质激素治疗可能导致认知和情感变化,这或许是由于糖皮质激素对海马神经发生及细胞增殖的抑制作用造成.帕罗西汀是一种选择性血清素重摄取抑制剂,临床常用作减轻抑郁症状,近几年来发现它能促进海马神经发生.本研究探讨帕罗西汀与慢性糖皮质激素的相互作用.方法 成年大鼠被分成四组,分别给予芝麻油、皮质酮、帕罗西汀或皮质酮和帕罗西汀十四天.溴脱氧尿嘧啶核苷(5-bromo-2-deoxyuridine,BrdU)免疫组化法被用于定量齿状回的细胞增殖.结果 皮质酮抑制了海马的细胞增殖,帕罗西汀增加了海马的细胞增殖.同时给药组还显示帕罗西汀能逆转皮质酮的抑制作用.结论 本研究结果对防止海马在类固醇治疗以后的损害或许有临床意义.-
dc.languageengen_US
dc.publisherScience Press (科學出版社) with Springer. The Journal's web site is located at http://www.neurosci.cn/en_HK
dc.relation.ispartofNeuroscience Bulletinen_HK
dc.relation.ispartof神经科学通报(英文版)-
dc.subjectBromodeoxyuridineen_HK
dc.subjectCell proliferationen_HK
dc.subjectCorticosteroneen_HK
dc.subjectHippocampusen_HK
dc.subjectNeurogenesisen_HK
dc.subjectParoxetineen_HK
dc.subject.meshAnalysis Of Varianceen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBromodeoxyuridine - Metabolismen_US
dc.subject.meshCell Counten_US
dc.subject.meshCell Proliferation - Drug Effectsen_US
dc.subject.meshCorticosterone - Pharmacologyen_US
dc.subject.meshDrug Interactionsen_US
dc.subject.meshHippocampus - Cytologyen_US
dc.subject.meshMaleen_US
dc.subject.meshNeural Inhibition - Drug Effectsen_US
dc.subject.meshNeurons - Drug Effectsen_US
dc.subject.meshParoxetine - Pharmacologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshSerotonin Uptake Inhibitors - Pharmacologyen_US
dc.subject.meshCorticosterone (皮质酮)-
dc.subject.meshNeurogenesis (神经发生)-
dc.subject.meshSesame Oil (芝麻油)-
dc.subject.meshUracil (尿嘧啶)-
dc.subject.meshParoxetine (帕罗西汀)-
dc.titleModulation of the suppressive effect of corticosterone on adult rat hippocampal cell proliferation by paroxetineen_HK
dc.title帕罗西汀对皮质酮抑制成年大鼠海马细胞增殖的调制作用-
dc.typeArticleen_HK
dc.identifier.emailLee, TMC:tmclee@hku.hken_HK
dc.identifier.emailSo, KF:hrmaskf@hkucc.hku.hken_HK
dc.identifier.authorityLee, TMC=rp00564en_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1007/s12264-007-0019-9en_HK
dc.identifier.pmid17612590-
dc.identifier.scopuseid_2-s2.0-34547097753en_HK
dc.identifier.hkuros137506-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34547097753&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume23en_HK
dc.identifier.issue3en_HK
dc.identifier.spage131en_HK
dc.identifier.epage136en_HK
dc.publisher.placeBeijing (北京)en_HK
dc.identifier.scopusauthoridQiu, G=36790708100en_HK
dc.identifier.scopusauthoridHelmeste, DM=7004506388en_HK
dc.identifier.scopusauthoridSamaranayake, AN=17344320600en_HK
dc.identifier.scopusauthoridLau, WM=16239172000en_HK
dc.identifier.scopusauthoridLee, TMC=7501437381en_HK
dc.identifier.scopusauthoridTang, SW=23968420300en_HK
dc.identifier.scopusauthoridSo, KF=34668391300en_HK
dc.customcontrol.immutablecsl 140618-

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