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Article: Corticosteroid decreases subventricular zone cell proliferation, which could be reversed by paroxetine

TitleCorticosteroid decreases subventricular zone cell proliferation, which could be reversed by paroxetine
Authors
KeywordsCorticosterone
Depression
Hypercortisolemia
Major depressive disorder
Neurogenesis
Paroxetine
SSRI
Subventricular zone
Issue Date2007
PublisherIOS Press. The Journal's web site is located at http://www.iospress.nl/html/09226028.php
Citation
Restorative Neurology And Neuroscience, 2007, v. 25 n. 1, p. 17-23 How to Cite?
AbstractPurpose: Major depressive disorder is often associated with elevated glucocorticoid levels, which in turn suppress cell proliferation and neurogenesis in the hippocampus. Increasing evidence supports that antidepressants induce hippocampal neurogenesis and this induces speculation that decrease in hippocampal neurogenesis has causal relationship with depression. There is, however, a lack of information about neurogenic effects of antidepressants on the subventricular zone, which is another CNS region with continuous neurogenesis throughout adulthood. In the present study, we investigated whether corticosterone and the SSRI paroxetine, have effects on SVZ cell proliferation. Methods: Rats were treated with the corresponding drugs for 14 days and the proliferating cells were labeled with bromodeoxyuridine (BrdU). BrdU labeled cells in the SVZ were quantified and analyzed. Results: In the corticosterone-treatment group, cell proliferation was decreased by 18% compared to vehicle-treatment group. Paroxetine-treatment group, in contrast, shows a 34% increase in cell proliferation. The decreased cell proliferation caused by corticosterone was prevented by paroxetine. Conclusions: Although corticosterone and antidepressants were found to affect cell proliferation in hippocampus, this is the first report to demonstrate that 1) corticosterone decreases cell proliferation in SVZ; 2) paroxetine promotes SVZ cell proliferation and 3) the suppressive effect on SVZ cell proliferation by corticosterone could be attenuated by paroxetine. These findings provide new insights into basic mechanisms of antidepressants, potential impact of steroid therapy on CNS neurogenesis, antidepressant mechanisms of action and potential involvement of the olfactory system in depression. © 2007 - IOS Press and the authors. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/149670
ISSN
2015 Impact Factor: 2.661
2015 SCImago Journal Rankings: 1.181
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLau, WMen_HK
dc.contributor.authorQiu, Gen_HK
dc.contributor.authorHelmeste, DMen_HK
dc.contributor.authorLee, TMCen_HK
dc.contributor.authorTang, SWen_HK
dc.contributor.authorSo, KFen_HK
dc.date.accessioned2012-06-26T05:56:49Z-
dc.date.available2012-06-26T05:56:49Z-
dc.date.issued2007en_HK
dc.identifier.citationRestorative Neurology And Neuroscience, 2007, v. 25 n. 1, p. 17-23en_HK
dc.identifier.issn0922-6028en_HK
dc.identifier.urihttp://hdl.handle.net/10722/149670-
dc.description.abstractPurpose: Major depressive disorder is often associated with elevated glucocorticoid levels, which in turn suppress cell proliferation and neurogenesis in the hippocampus. Increasing evidence supports that antidepressants induce hippocampal neurogenesis and this induces speculation that decrease in hippocampal neurogenesis has causal relationship with depression. There is, however, a lack of information about neurogenic effects of antidepressants on the subventricular zone, which is another CNS region with continuous neurogenesis throughout adulthood. In the present study, we investigated whether corticosterone and the SSRI paroxetine, have effects on SVZ cell proliferation. Methods: Rats were treated with the corresponding drugs for 14 days and the proliferating cells were labeled with bromodeoxyuridine (BrdU). BrdU labeled cells in the SVZ were quantified and analyzed. Results: In the corticosterone-treatment group, cell proliferation was decreased by 18% compared to vehicle-treatment group. Paroxetine-treatment group, in contrast, shows a 34% increase in cell proliferation. The decreased cell proliferation caused by corticosterone was prevented by paroxetine. Conclusions: Although corticosterone and antidepressants were found to affect cell proliferation in hippocampus, this is the first report to demonstrate that 1) corticosterone decreases cell proliferation in SVZ; 2) paroxetine promotes SVZ cell proliferation and 3) the suppressive effect on SVZ cell proliferation by corticosterone could be attenuated by paroxetine. These findings provide new insights into basic mechanisms of antidepressants, potential impact of steroid therapy on CNS neurogenesis, antidepressant mechanisms of action and potential involvement of the olfactory system in depression. © 2007 - IOS Press and the authors. All rights reserved.en_HK
dc.languageengen_US
dc.publisherIOS Press. The Journal's web site is located at http://www.iospress.nl/html/09226028.phpen_HK
dc.relation.ispartofRestorative Neurology and Neuroscienceen_HK
dc.subjectCorticosteroneen_HK
dc.subjectDepressionen_HK
dc.subjectHypercortisolemiaen_HK
dc.subjectMajor depressive disorderen_HK
dc.subjectNeurogenesisen_HK
dc.subjectParoxetineen_HK
dc.subjectSSRIen_HK
dc.subjectSubventricular zoneen_HK
dc.subject.meshAdrenal Cortex Hormones - Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBromodeoxyuridine - Metabolismen_US
dc.subject.meshCell Count - Methodsen_US
dc.subject.meshCell Proliferation - Drug Effectsen_US
dc.subject.meshCerebral Ventricles - Cytology - Drug Effectsen_US
dc.subject.meshDrug Interactionsen_US
dc.subject.meshMaleen_US
dc.subject.meshParoxetine - Pharmacologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshSerotonin Uptake Inhibitors - Pharmacologyen_US
dc.subject.meshStatistics, Nonparametricen_US
dc.subject.meshTime Factorsen_US
dc.titleCorticosteroid decreases subventricular zone cell proliferation, which could be reversed by paroxetineen_HK
dc.typeArticleen_HK
dc.identifier.emailLee, TMC:tmclee@hku.hken_HK
dc.identifier.emailSo, KF:hrmaskf@hkucc.hku.hken_HK
dc.identifier.authorityLee, TMC=rp00564en_HK
dc.identifier.authoritySo, KF=rp00329en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid17473392-
dc.identifier.scopuseid_2-s2.0-34247364096en_HK
dc.identifier.hkuros139282-
dc.identifier.hkuros135083-
dc.identifier.hkuros115721-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-34247364096&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume25en_HK
dc.identifier.issue1en_HK
dc.identifier.spage17en_HK
dc.identifier.epage23en_HK
dc.identifier.isiWOS:000248393000003-
dc.publisher.placeNetherlandsen_HK
dc.identifier.scopusauthoridLau, WM=16239172000en_HK
dc.identifier.scopusauthoridQiu, G=36790708100en_HK
dc.identifier.scopusauthoridHelmeste, DM=7004506388en_HK
dc.identifier.scopusauthoridLee, TMC=7501437381en_HK
dc.identifier.scopusauthoridTang, SW=23968420300en_HK
dc.identifier.scopusauthoridSo, KF=34668391300en_HK

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