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Article: Morphine acts via μ-opioid receptors to enhance spinal regeneration and synaptic reconstruction of primary afferent fibers injured by sciatic nerve crush

TitleMorphine acts via μ-opioid receptors to enhance spinal regeneration and synaptic reconstruction of primary afferent fibers injured by sciatic nerve crush
Authors
Issue Date2007
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainres
Citation
Brain Research, 2007, v. 1130 n. 1, p. 108-113 How to Cite?
AbstractThe present study investigated whether morphine can promote regeneration and synaptic reconstruction of the terminals of injured primary afferent fibers in lamina II of the spinal cord in rats following sciatic nerve injury. Fluoride-resistant acid phosphatase (FRAP)-positive terminals in lamina II of the L4 spinal segment after sciatic nerve injury were assessed after treatment with vehicle, morphine, and naloxone plus morphine. Under the electron microscope, types I and II complex terminals of unmyelinated afferent fibers from the dorsal root, simple terminals of interneuronal axons, and terminals of descending axons at lamina II of the L4 spinal segment were documented in the different groups after injury. FRAP-positive terminals in lamina II were depleted after sciatic nerve injury in the vehicle group. Treatment with morphine increased the numbers of FRAP-positive terminals, and this was prevented by naloxone. The present study demonstrates that morphine may promote the regeneration and synaptic reconstruction of the terminals of injured primary unmyelinated afferent fibers in lamina II of spinal cord, by a process mediated by μ-opioid receptors. © 2006 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/149667
ISSN
2015 Impact Factor: 2.561
2015 SCImago Journal Rankings: 1.351
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZeng, YSen_US
dc.contributor.authorNie, JHen_US
dc.contributor.authorZhang, Wen_US
dc.contributor.authorChen, SJen_US
dc.contributor.authorWu, Wen_US
dc.date.accessioned2012-06-26T05:56:47Z-
dc.date.available2012-06-26T05:56:47Z-
dc.date.issued2007en_US
dc.identifier.citationBrain Research, 2007, v. 1130 n. 1, p. 108-113en_US
dc.identifier.issn0006-8993en_US
dc.identifier.urihttp://hdl.handle.net/10722/149667-
dc.description.abstractThe present study investigated whether morphine can promote regeneration and synaptic reconstruction of the terminals of injured primary afferent fibers in lamina II of the spinal cord in rats following sciatic nerve injury. Fluoride-resistant acid phosphatase (FRAP)-positive terminals in lamina II of the L4 spinal segment after sciatic nerve injury were assessed after treatment with vehicle, morphine, and naloxone plus morphine. Under the electron microscope, types I and II complex terminals of unmyelinated afferent fibers from the dorsal root, simple terminals of interneuronal axons, and terminals of descending axons at lamina II of the L4 spinal segment were documented in the different groups after injury. FRAP-positive terminals in lamina II were depleted after sciatic nerve injury in the vehicle group. Treatment with morphine increased the numbers of FRAP-positive terminals, and this was prevented by naloxone. The present study demonstrates that morphine may promote the regeneration and synaptic reconstruction of the terminals of injured primary unmyelinated afferent fibers in lamina II of spinal cord, by a process mediated by μ-opioid receptors. © 2006 Elsevier B.V. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainresen_US
dc.relation.ispartofBrain Researchen_US
dc.subject.meshAcid Phosphatase - Metabolismen_US
dc.subject.meshAfferent Pathways - Cytology - Drug Effects - Metabolismen_US
dc.subject.meshAnimalsen_US
dc.subject.meshMaleen_US
dc.subject.meshMorphine - Metabolismen_US
dc.subject.meshNerve Crushen_US
dc.subject.meshNerve Fibers, Unmyelinated - Drug Effects - Metabolismen_US
dc.subject.meshNerve Regeneration - Drug Effects - Physiologyen_US
dc.subject.meshNeuroprotective Agents - Metabolismen_US
dc.subject.meshProtein Kinases - Metabolismen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshReceptors, Opioid, Mu - Metabolismen_US
dc.subject.meshSciatic Nerve - Cytology - Injuries - Physiologyen_US
dc.subject.meshSpinal Cord - Cytology - Metabolismen_US
dc.subject.meshSynapses - Drug Effects - Physiology - Ultrastructureen_US
dc.subject.meshTor Serine-Threonine Kinasesen_US
dc.titleMorphine acts via μ-opioid receptors to enhance spinal regeneration and synaptic reconstruction of primary afferent fibers injured by sciatic nerve crushen_US
dc.typeArticleen_US
dc.identifier.emailWu, W:wtwu@hkucc.hku.hken_US
dc.identifier.authorityWu, W=rp00419en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.brainres.2006.10.079en_US
dc.identifier.pmid17169344-
dc.identifier.scopuseid_2-s2.0-33845967097en_US
dc.identifier.hkuros137847-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33845967097&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume1130en_US
dc.identifier.issue1en_US
dc.identifier.spage108en_US
dc.identifier.epage113en_US
dc.identifier.isiWOS:000244072200012-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridZeng, YS=8236229300en_US
dc.identifier.scopusauthoridNie, JH=36935843500en_US
dc.identifier.scopusauthoridZhang, W=36076785500en_US
dc.identifier.scopusauthoridChen, SJ=12809083300en_US
dc.identifier.scopusauthoridWu, W=7407081122en_US
dc.identifier.citeulike6945757-

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