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Article: LINGO-1 antagonist promotes functional recovery and axonal sprouting after spinal cord injury

TitleLINGO-1 antagonist promotes functional recovery and axonal sprouting after spinal cord injury
Authors
Issue Date2006
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ymcne
Citation
Molecular And Cellular Neuroscience, 2006, v. 33 n. 3, p. 311-320 How to Cite?
AbstractLINGO-1 is a CNS-specific protein and a functional component of the NgR1/p75/LINGO-1 and NgR1/TAJ(TROY)/LINGO-1 signaling complexes that mediate inhibition of axonal outgrowth. These receptor complexes mediate the axonal growth inhibitory effects of Nogo, myelin-associated glycoprotein (MAG) and oligodendrocyte-myelin glycoprotein (OMgp) via RhoA activation. Soluble LINGO-1 (LINGO-1-Fc), which acts as an antagonist of these pathways by blocking LINGO-1 binding to NgR1, was administered to rats after dorsal or lateral hemisection of the spinal cord. LINGO-1-Fc treatment significantly improved functional recovery, promoted axonal sprouting and decreased RhoA activation and increased oligodendrocyte and neuronal survival after either rubrospinal or corticospinal tract transection. These experiments demonstrate an important role for LINGO-1 in modulating axonal outgrowth in vivo and that treatment with LINGO-1-Fc can significantly enhance recovery after spinal cord injury. © 2006 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/149665
ISSN
2015 Impact Factor: 3.597
2015 SCImago Journal Rankings: 2.342
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorJi, Ben_US
dc.contributor.authorLi, Men_US
dc.contributor.authorWu, WTen_US
dc.contributor.authorYick, LWen_US
dc.contributor.authorLee, Xen_US
dc.contributor.authorShao, Zen_US
dc.contributor.authorWang, Jen_US
dc.contributor.authorSo, KFen_US
dc.contributor.authorMccoy, JMen_US
dc.contributor.authorBlake Pepinsky, Ren_US
dc.contributor.authorMi, Sen_US
dc.contributor.authorRelton, JKen_US
dc.date.accessioned2012-06-26T05:56:45Z-
dc.date.available2012-06-26T05:56:45Z-
dc.date.issued2006en_US
dc.identifier.citationMolecular And Cellular Neuroscience, 2006, v. 33 n. 3, p. 311-320en_US
dc.identifier.issn1044-7431en_US
dc.identifier.urihttp://hdl.handle.net/10722/149665-
dc.description.abstractLINGO-1 is a CNS-specific protein and a functional component of the NgR1/p75/LINGO-1 and NgR1/TAJ(TROY)/LINGO-1 signaling complexes that mediate inhibition of axonal outgrowth. These receptor complexes mediate the axonal growth inhibitory effects of Nogo, myelin-associated glycoprotein (MAG) and oligodendrocyte-myelin glycoprotein (OMgp) via RhoA activation. Soluble LINGO-1 (LINGO-1-Fc), which acts as an antagonist of these pathways by blocking LINGO-1 binding to NgR1, was administered to rats after dorsal or lateral hemisection of the spinal cord. LINGO-1-Fc treatment significantly improved functional recovery, promoted axonal sprouting and decreased RhoA activation and increased oligodendrocyte and neuronal survival after either rubrospinal or corticospinal tract transection. These experiments demonstrate an important role for LINGO-1 in modulating axonal outgrowth in vivo and that treatment with LINGO-1-Fc can significantly enhance recovery after spinal cord injury. © 2006 Elsevier Inc. All rights reserved.en_US
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ymcneen_US
dc.relation.ispartofMolecular and Cellular Neuroscienceen_US
dc.subject.meshAnalysis Of Varianceen_US
dc.subject.meshAnimalsen_US
dc.subject.meshApoptosis - Drug Effectsen_US
dc.subject.meshAxons - Drug Effects - Physiologyen_US
dc.subject.meshCaspase 3 - Metabolismen_US
dc.subject.meshDisease Models, Animalen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshForelimb - Drug Effectsen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunohistochemistry - Methodsen_US
dc.subject.meshIn Situ Nick-End Labeling - Methodsen_US
dc.subject.meshMap Kinase Kinase 4 - Metabolismen_US
dc.subject.meshMembrane Proteins - Antagonists & Inhibitors - Chemistry - Physiologyen_US
dc.subject.meshNerve Regeneration - Drug Effectsen_US
dc.subject.meshNerve Tissue Proteins - Antagonists & Inhibitors - Chemistry - Physiologyen_US
dc.subject.meshOrganogenesis - Drug Effectsen_US
dc.subject.meshProtein Binding - Drug Effectsen_US
dc.subject.meshRna-Binding Proteins - Metabolismen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshRecombinant Fusion Proteins - Therapeutic Useen_US
dc.subject.meshRecovery Of Function - Drug Effectsen_US
dc.subject.meshSpinal Cord Injuries - Drug Therapy - Pathology - Physiopathologyen_US
dc.subject.meshTime Factorsen_US
dc.subject.meshTubulin - Metabolismen_US
dc.subject.meshRhoa Gtp-Binding Protein - Metabolismen_US
dc.titleLINGO-1 antagonist promotes functional recovery and axonal sprouting after spinal cord injuryen_US
dc.typeArticleen_US
dc.identifier.emailWu, WT:wtwu@hkucc.hku.hken_US
dc.identifier.emailSo, KF:hrmaskf@hkucc.hku.hken_US
dc.identifier.authorityWu, WT=rp00419en_US
dc.identifier.authoritySo, KF=rp00329en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.mcn.2006.08.003en_US
dc.identifier.pmid17011208-
dc.identifier.scopuseid_2-s2.0-33750629457en_US
dc.identifier.hkuros132964-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33750629457&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume33en_US
dc.identifier.issue3en_US
dc.identifier.spage311en_US
dc.identifier.epage320en_US
dc.identifier.isiWOS:000242224900008-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridJi, B=7102566175en_US
dc.identifier.scopusauthoridLi, M=7405260421en_US
dc.identifier.scopusauthoridWu, WT=7407081122en_US
dc.identifier.scopusauthoridYick, LW=6603414804en_US
dc.identifier.scopusauthoridLee, X=36710111000en_US
dc.identifier.scopusauthoridShao, Z=7202244441en_US
dc.identifier.scopusauthoridWang, J=8940579500en_US
dc.identifier.scopusauthoridSo, KF=34668391300en_US
dc.identifier.scopusauthoridMcCoy, JM=7201354663en_US
dc.identifier.scopusauthoridBlake Pepinsky, R=6507563214en_US
dc.identifier.scopusauthoridMi, S=7004825561en_US
dc.identifier.scopusauthoridRelton, JK=7004202828en_US

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