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Article: LINGO-1 antagonist promotes functional recovery and axonal sprouting after spinal cord injury
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TitleLINGO-1 antagonist promotes functional recovery and axonal sprouting after spinal cord injury
 
AuthorsJi, B2
Li, M2
Wu, WT1
Yick, LW1
Lee, X2
Shao, Z2
Wang, J2
So, KF1
Mccoy, JM2
Blake Pepinsky, R2
Mi, S2
Relton, JK2
 
Issue Date2006
 
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ymcne
 
CitationMolecular And Cellular Neuroscience, 2006, v. 33 n. 3, p. 311-320 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.mcn.2006.08.003
 
AbstractLINGO-1 is a CNS-specific protein and a functional component of the NgR1/p75/LINGO-1 and NgR1/TAJ(TROY)/LINGO-1 signaling complexes that mediate inhibition of axonal outgrowth. These receptor complexes mediate the axonal growth inhibitory effects of Nogo, myelin-associated glycoprotein (MAG) and oligodendrocyte-myelin glycoprotein (OMgp) via RhoA activation. Soluble LINGO-1 (LINGO-1-Fc), which acts as an antagonist of these pathways by blocking LINGO-1 binding to NgR1, was administered to rats after dorsal or lateral hemisection of the spinal cord. LINGO-1-Fc treatment significantly improved functional recovery, promoted axonal sprouting and decreased RhoA activation and increased oligodendrocyte and neuronal survival after either rubrospinal or corticospinal tract transection. These experiments demonstrate an important role for LINGO-1 in modulating axonal outgrowth in vivo and that treatment with LINGO-1-Fc can significantly enhance recovery after spinal cord injury. © 2006 Elsevier Inc. All rights reserved.
 
ISSN1044-7431
2013 Impact Factor: 3.734
 
DOIhttp://dx.doi.org/10.1016/j.mcn.2006.08.003
 
ISI Accession Number IDWOS:000242224900008
 
ReferencesReferences in Scopus
 
DC FieldValue
dc.contributor.authorJi, B
 
dc.contributor.authorLi, M
 
dc.contributor.authorWu, WT
 
dc.contributor.authorYick, LW
 
dc.contributor.authorLee, X
 
dc.contributor.authorShao, Z
 
dc.contributor.authorWang, J
 
dc.contributor.authorSo, KF
 
dc.contributor.authorMccoy, JM
 
dc.contributor.authorBlake Pepinsky, R
 
dc.contributor.authorMi, S
 
dc.contributor.authorRelton, JK
 
dc.date.accessioned2012-06-26T05:56:45Z
 
dc.date.available2012-06-26T05:56:45Z
 
dc.date.issued2006
 
dc.description.abstractLINGO-1 is a CNS-specific protein and a functional component of the NgR1/p75/LINGO-1 and NgR1/TAJ(TROY)/LINGO-1 signaling complexes that mediate inhibition of axonal outgrowth. These receptor complexes mediate the axonal growth inhibitory effects of Nogo, myelin-associated glycoprotein (MAG) and oligodendrocyte-myelin glycoprotein (OMgp) via RhoA activation. Soluble LINGO-1 (LINGO-1-Fc), which acts as an antagonist of these pathways by blocking LINGO-1 binding to NgR1, was administered to rats after dorsal or lateral hemisection of the spinal cord. LINGO-1-Fc treatment significantly improved functional recovery, promoted axonal sprouting and decreased RhoA activation and increased oligodendrocyte and neuronal survival after either rubrospinal or corticospinal tract transection. These experiments demonstrate an important role for LINGO-1 in modulating axonal outgrowth in vivo and that treatment with LINGO-1-Fc can significantly enhance recovery after spinal cord injury. © 2006 Elsevier Inc. All rights reserved.
 
dc.description.natureLink_to_subscribed_fulltext
 
dc.identifier.citationMolecular And Cellular Neuroscience, 2006, v. 33 n. 3, p. 311-320 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.mcn.2006.08.003
 
dc.identifier.doihttp://dx.doi.org/10.1016/j.mcn.2006.08.003
 
dc.identifier.epage320
 
dc.identifier.hkuros132964
 
dc.identifier.isiWOS:000242224900008
 
dc.identifier.issn1044-7431
2013 Impact Factor: 3.734
 
dc.identifier.issue3
 
dc.identifier.pmid17011208
 
dc.identifier.scopuseid_2-s2.0-33750629457
 
dc.identifier.spage311
 
dc.identifier.urihttp://hdl.handle.net/10722/149665
 
dc.identifier.volume33
 
dc.languageeng
 
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ymcne
 
dc.publisher.placeUnited States
 
dc.relation.ispartofMolecular and Cellular Neuroscience
 
dc.relation.referencesReferences in Scopus
 
dc.subject.meshAnalysis Of Variance
 
dc.subject.meshAnimals
 
dc.subject.meshApoptosis - Drug Effects
 
dc.subject.meshAxons - Drug Effects - Physiology
 
dc.subject.meshCaspase 3 - Metabolism
 
dc.subject.meshDisease Models, Animal
 
dc.subject.meshDose-Response Relationship, Drug
 
dc.subject.meshForelimb - Drug Effects
 
dc.subject.meshHumans
 
dc.subject.meshImmunohistochemistry - Methods
 
dc.subject.meshIn Situ Nick-End Labeling - Methods
 
dc.subject.meshMap Kinase Kinase 4 - Metabolism
 
dc.subject.meshMembrane Proteins - Antagonists & Inhibitors - Chemistry - Physiology
 
dc.subject.meshNerve Regeneration - Drug Effects
 
dc.subject.meshNerve Tissue Proteins - Antagonists & Inhibitors - Chemistry - Physiology
 
dc.subject.meshOrganogenesis - Drug Effects
 
dc.subject.meshProtein Binding - Drug Effects
 
dc.subject.meshRna-Binding Proteins - Metabolism
 
dc.subject.meshRats
 
dc.subject.meshRats, Sprague-Dawley
 
dc.subject.meshRecombinant Fusion Proteins - Therapeutic Use
 
dc.subject.meshRecovery Of Function - Drug Effects
 
dc.subject.meshSpinal Cord Injuries - Drug Therapy - Pathology - Physiopathology
 
dc.subject.meshTime Factors
 
dc.subject.meshTubulin - Metabolism
 
dc.subject.meshRhoa Gtp-Binding Protein - Metabolism
 
dc.titleLINGO-1 antagonist promotes functional recovery and axonal sprouting after spinal cord injury
 
dc.typeArticle
 
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Author Affiliations
  1. The University of Hong Kong
  2. Biogen IDEC