Article: LINGO-1 antagonist promotes functional recovery and axonal sprouting after spinal cord injury

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TitleLINGO-1 antagonist promotes functional recovery and axonal sprouting after spinal cord injury
AuthorsJi, B2
Li, M2
Wu, WT1
Yick, LW1
Lee, X2
Shao, Z2
Wang, J2
So, KF1
Mccoy, JM2
Blake Pepinsky, R2
Mi, S2
Relton, JK2
Issue Date2006
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ymcne
CitationMolecular And Cellular Neuroscience, 2006, v. 33 n. 3, p. 311-320 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.mcn.2006.08.003
AbstractLINGO-1 is a CNS-specific protein and a functional component of the NgR1/p75/LINGO-1 and NgR1/TAJ(TROY)/LINGO-1 signaling complexes that mediate inhibition of axonal outgrowth. These receptor complexes mediate the axonal growth inhibitory effects of Nogo, myelin-associated glycoprotein (MAG) and oligodendrocyte-myelin glycoprotein (OMgp) via RhoA activation. Soluble LINGO-1 (LINGO-1-Fc), which acts as an antagonist of these pathways by blocking LINGO-1 binding to NgR1, was administered to rats after dorsal or lateral hemisection of the spinal cord. LINGO-1-Fc treatment significantly improved functional recovery, promoted axonal sprouting and decreased RhoA activation and increased oligodendrocyte and neuronal survival after either rubrospinal or corticospinal tract transection. These experiments demonstrate an important role for LINGO-1 in modulating axonal outgrowth in vivo and that treatment with LINGO-1-Fc can significantly enhance recovery after spinal cord injury. © 2006 Elsevier Inc. All rights reserved.
ISSN1044-7431
2011 Impact Factor: 3.663
2011 SCImago Journal Rankings: 0.486
DOIhttp://dx.doi.org/10.1016/j.mcn.2006.08.003
ISI Accession Number IDWOS:000242224900008
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorJi, B
dc.contributor.authorLi, M
dc.contributor.authorWu, WT
dc.contributor.authorYick, LW
dc.contributor.authorLee, X
dc.contributor.authorShao, Z
dc.contributor.authorWang, J
dc.contributor.authorSo, KF
dc.contributor.authorMccoy, JM
dc.contributor.authorBlake Pepinsky, R
dc.contributor.authorMi, S
dc.contributor.authorRelton, JK
dc.date.accessioned2012-06-26T05:56:45Z
dc.date.available2012-06-26T05:56:45Z
dc.date.issued2006
dc.description.abstractLINGO-1 is a CNS-specific protein and a functional component of the NgR1/p75/LINGO-1 and NgR1/TAJ(TROY)/LINGO-1 signaling complexes that mediate inhibition of axonal outgrowth. These receptor complexes mediate the axonal growth inhibitory effects of Nogo, myelin-associated glycoprotein (MAG) and oligodendrocyte-myelin glycoprotein (OMgp) via RhoA activation. Soluble LINGO-1 (LINGO-1-Fc), which acts as an antagonist of these pathways by blocking LINGO-1 binding to NgR1, was administered to rats after dorsal or lateral hemisection of the spinal cord. LINGO-1-Fc treatment significantly improved functional recovery, promoted axonal sprouting and decreased RhoA activation and increased oligodendrocyte and neuronal survival after either rubrospinal or corticospinal tract transection. These experiments demonstrate an important role for LINGO-1 in modulating axonal outgrowth in vivo and that treatment with LINGO-1-Fc can significantly enhance recovery after spinal cord injury. © 2006 Elsevier Inc. All rights reserved.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationMolecular And Cellular Neuroscience, 2006, v. 33 n. 3, p. 311-320 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.mcn.2006.08.003
dc.identifier.doihttp://dx.doi.org/10.1016/j.mcn.2006.08.003
dc.identifier.epage320
dc.identifier.hkuros132964
dc.identifier.isiWOS:000242224900008
dc.identifier.issn1044-7431
2011 Impact Factor: 3.663
2011 SCImago Journal Rankings: 0.486
dc.identifier.issue3
dc.identifier.pmid17011208
dc.identifier.scopuseid_2-s2.0-33750629457
dc.identifier.spage311
dc.identifier.urihttp://hdl.handle.net/10722/149665
dc.identifier.volume33
dc.languageeng
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ymcne
dc.publisher.placeUnited States
dc.relation.ispartofMolecular and Cellular Neuroscience
dc.relation.referencesReferences in Scopus
dc.subject.meshAnalysis Of Variance
dc.subject.meshAnimals
dc.subject.meshApoptosis - Drug Effects
dc.subject.meshAxons - Drug Effects - Physiology
dc.subject.meshCaspase 3 - Metabolism
dc.subject.meshDisease Models, Animal
dc.subject.meshDose-Response Relationship, Drug
dc.subject.meshForelimb - Drug Effects
dc.subject.meshHumans
dc.subject.meshImmunohistochemistry - Methods
dc.subject.meshIn Situ Nick-End Labeling - Methods
dc.subject.meshMap Kinase Kinase 4 - Metabolism
dc.subject.meshMembrane Proteins - Antagonists & Inhibitors - Chemistry - Physiology
dc.subject.meshNerve Regeneration - Drug Effects
dc.subject.meshNerve Tissue Proteins - Antagonists & Inhibitors - Chemistry - Physiology
dc.subject.meshOrganogenesis - Drug Effects
dc.subject.meshProtein Binding - Drug Effects
dc.subject.meshRna-Binding Proteins - Metabolism
dc.subject.meshRats
dc.subject.meshRats, Sprague-Dawley
dc.subject.meshRecombinant Fusion Proteins - Therapeutic Use
dc.subject.meshRecovery Of Function - Drug Effects
dc.subject.meshSpinal Cord Injuries - Drug Therapy - Pathology - Physiopathology
dc.subject.meshTime Factors
dc.subject.meshTubulin - Metabolism
dc.subject.meshRhoa Gtp-Binding Protein - Metabolism
dc.titleLINGO-1 antagonist promotes functional recovery and axonal sprouting after spinal cord injury
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong
  2. Biogen IDEC