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Article: The response of magnocellular neurons of the hypothalamo-neurohyphyseal system to hypophysectomy, nitric oxide synthase expression as well as survival and regeneration in developing vs. adult rats

TitleThe response of magnocellular neurons of the hypothalamo-neurohyphyseal system to hypophysectomy, nitric oxide synthase expression as well as survival and regeneration in developing vs. adult rats
Authors
Issue Date2006
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainres
Citation
Brain Research, 2006, v. 1113 n. 1, p. 45-53 How to Cite?
AbstractThis study examined the age-related changes in nitric oxide synthase immunoreactivity (NOS-IR), survival and regeneration of magnocellular neurons in the hypothalamo-neurohypophyseal system (HNS) in rats following hypophysectomy. In adult animal, hypophysectomy induced a significant increase in NOS-IR in the supraoptic (SON), paraventricular nuclei (PVN) and median eminence (ME) by 3 days post-lesion. NOS sustained an increased level until 2 weeks after hypophysectomy and then returned to normal control level. In contrast, at postnatal day 7 (PN7), no obvious increase in NOS-IR was observed in the SON, PVN and ME following the injury compared with age-matched controls. At PN14, the same injury induced an increase in NOS-IR in SON, PVN and ME but the increase was more transient with peak NOS-IR at 3 days and returning to the corresponding control level at 1 week after hypophysectomy. In contrast to a striking age-dependent alteration in NOS-IR in the SON and PVN, hypophysectomy induced substantial degeneration of arginine vasopressin (AVP) and oxytocin (OT) neurons in the SON and PVN in both immature and adult rats and there was no obvious difference in neuronal survival after the same injury among these three groups of different ages by quantitative analysis. Following hypophysectomy, a large number of fibers were observed in the contact zone of the median eminence and the adjacent lumen of the third cerebral ventricle (V3) in adult rats, whereas few fibers could be found in the lumen of the V3 in the immature rats after the same injury. Relationships between NOS induction and magnocellular neuronal survival and regeneration were discussed. © 2006.
Persistent Identifierhttp://hdl.handle.net/10722/149661
ISSN
2015 Impact Factor: 2.561
2015 SCImago Journal Rankings: 1.351
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorYuan, Qen_US
dc.contributor.authorScott, DEen_US
dc.contributor.authorSo, KFen_US
dc.contributor.authorWu, Wen_US
dc.date.accessioned2012-06-26T05:56:42Z-
dc.date.available2012-06-26T05:56:42Z-
dc.date.issued2006en_US
dc.identifier.citationBrain Research, 2006, v. 1113 n. 1, p. 45-53en_US
dc.identifier.issn0006-8993en_US
dc.identifier.urihttp://hdl.handle.net/10722/149661-
dc.description.abstractThis study examined the age-related changes in nitric oxide synthase immunoreactivity (NOS-IR), survival and regeneration of magnocellular neurons in the hypothalamo-neurohypophyseal system (HNS) in rats following hypophysectomy. In adult animal, hypophysectomy induced a significant increase in NOS-IR in the supraoptic (SON), paraventricular nuclei (PVN) and median eminence (ME) by 3 days post-lesion. NOS sustained an increased level until 2 weeks after hypophysectomy and then returned to normal control level. In contrast, at postnatal day 7 (PN7), no obvious increase in NOS-IR was observed in the SON, PVN and ME following the injury compared with age-matched controls. At PN14, the same injury induced an increase in NOS-IR in SON, PVN and ME but the increase was more transient with peak NOS-IR at 3 days and returning to the corresponding control level at 1 week after hypophysectomy. In contrast to a striking age-dependent alteration in NOS-IR in the SON and PVN, hypophysectomy induced substantial degeneration of arginine vasopressin (AVP) and oxytocin (OT) neurons in the SON and PVN in both immature and adult rats and there was no obvious difference in neuronal survival after the same injury among these three groups of different ages by quantitative analysis. Following hypophysectomy, a large number of fibers were observed in the contact zone of the median eminence and the adjacent lumen of the third cerebral ventricle (V3) in adult rats, whereas few fibers could be found in the lumen of the V3 in the immature rats after the same injury. Relationships between NOS induction and magnocellular neuronal survival and regeneration were discussed. © 2006.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainresen_US
dc.relation.ispartofBrain Researchen_US
dc.subject.meshAge Factorsen_US
dc.subject.meshAnalysis Of Varianceen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnimals, Newbornen_US
dc.subject.meshArginine Vasopressin - Metabolismen_US
dc.subject.meshCell Count - Methodsen_US
dc.subject.meshCell Survival - Physiologyen_US
dc.subject.meshGene Expression Regulation, Developmental - Physiologyen_US
dc.subject.meshHypophysectomy - Methodsen_US
dc.subject.meshHypothalamus - Cytologyen_US
dc.subject.meshImmunohistochemistry - Methodsen_US
dc.subject.meshMaleen_US
dc.subject.meshMicroscopy, Electron, Scanning - Methodsen_US
dc.subject.meshNerve Regeneration - Physiologyen_US
dc.subject.meshNeurons - Physiologyen_US
dc.subject.meshNitric Oxide Synthase - Metabolismen_US
dc.subject.meshOxytocin - Metabolismen_US
dc.subject.meshRatsen_US
dc.subject.meshThird Ventricle - Ultrastructureen_US
dc.titleThe response of magnocellular neurons of the hypothalamo-neurohyphyseal system to hypophysectomy, nitric oxide synthase expression as well as survival and regeneration in developing vs. adult ratsen_US
dc.typeArticleen_US
dc.identifier.emailSo, KF:hrmaskf@hkucc.hku.hken_US
dc.identifier.emailWu, W:wtwu@hkucc.hku.hken_US
dc.identifier.authoritySo, KF=rp00329en_US
dc.identifier.authorityWu, W=rp00419en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.brainres.2006.07.052en_US
dc.identifier.pmid16949057-
dc.identifier.scopuseid_2-s2.0-33748693316en_US
dc.identifier.hkuros125780-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33748693316&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume1113en_US
dc.identifier.issue1en_US
dc.identifier.spage45en_US
dc.identifier.epage53en_US
dc.identifier.isiWOS:000241398500005-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridYuan, Q=7202814773en_US
dc.identifier.scopusauthoridScott, DE=40262460100en_US
dc.identifier.scopusauthoridSo, KF=34668391300en_US
dc.identifier.scopusauthoridWu, W=7407081122en_US

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