File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Changes of retinal functions following the induction of ocular hypertension in rats using argon laser photocoagulation

TitleChanges of retinal functions following the induction of ocular hypertension in rats using argon laser photocoagulation
Authors
Issue Date2006
PublisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEO
Citation
Clinical And Experimental Ophthalmology, 2006, v. 34 n. 6, p. 575-583 How to Cite?
AbstractBackground: Electroretinography (ERG) provides a longitudinal monitoring of pathological changes in retina. Scotopic threshold response (STR) of ERG was shown to reflect inner retinal activity and is particularly useful in the evaluation of inner retinal changes in ocular hypertension models. Recently, STR was demonstrated to be attenuated after the induction of ocular hypertension using injection of hypertonic saline into episcleral veins which indicates an impairment of retinal function. However, little is known on the changes of retinal function in an ocular hypertension model induced by laser photocoagulation at episcleral veins and limbal veins. Methods: Ocular hypertension was induced unilaterally using laser photocoagulation at episcleral veins and limbal veins in adult Sprague-Dawley rats. Intraocular pressure was monitored and the number of retinal ganglion cell loss was counted across the 8-week experimental period. The animals were dark adapted overnight and flash ERGs were measured before the laser treatment, 5 and 8 weeks after treatment. The changes of STR, scotopic negative response, a-wave and b-wave were analysed. Results: Approximately 1.6-fold elevation of intraocular pressure was induced in the experimental eyes and 3% retinal ganglion cell loss per week was found. The amplitude of STR was significantly attenuated which indicates an impairment of inner retinal activities. There was also a reduction of scotopic negative response, a-wave and b-wave after the induction of ocular hypertension. Conclusions: The laser-induced ocular hypertension model in the present study produced a substantial reduction of retinal functions. Understanding the characteristic of pathological changes is crucial for further study using this model. © 2006 Royal Australian and New Zealand College of Ophthalmologists.
Persistent Identifierhttp://hdl.handle.net/10722/149660
ISSN
2015 Impact Factor: 2.546
2015 SCImago Journal Rankings: 1.335
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorLi, RSen_US
dc.contributor.authorTay, DKen_US
dc.contributor.authorChan, HHLen_US
dc.contributor.authorSo, KFen_US
dc.date.accessioned2012-06-26T05:56:41Z-
dc.date.available2012-06-26T05:56:41Z-
dc.date.issued2006en_US
dc.identifier.citationClinical And Experimental Ophthalmology, 2006, v. 34 n. 6, p. 575-583en_US
dc.identifier.issn1442-6404en_US
dc.identifier.urihttp://hdl.handle.net/10722/149660-
dc.description.abstractBackground: Electroretinography (ERG) provides a longitudinal monitoring of pathological changes in retina. Scotopic threshold response (STR) of ERG was shown to reflect inner retinal activity and is particularly useful in the evaluation of inner retinal changes in ocular hypertension models. Recently, STR was demonstrated to be attenuated after the induction of ocular hypertension using injection of hypertonic saline into episcleral veins which indicates an impairment of retinal function. However, little is known on the changes of retinal function in an ocular hypertension model induced by laser photocoagulation at episcleral veins and limbal veins. Methods: Ocular hypertension was induced unilaterally using laser photocoagulation at episcleral veins and limbal veins in adult Sprague-Dawley rats. Intraocular pressure was monitored and the number of retinal ganglion cell loss was counted across the 8-week experimental period. The animals were dark adapted overnight and flash ERGs were measured before the laser treatment, 5 and 8 weeks after treatment. The changes of STR, scotopic negative response, a-wave and b-wave were analysed. Results: Approximately 1.6-fold elevation of intraocular pressure was induced in the experimental eyes and 3% retinal ganglion cell loss per week was found. The amplitude of STR was significantly attenuated which indicates an impairment of inner retinal activities. There was also a reduction of scotopic negative response, a-wave and b-wave after the induction of ocular hypertension. Conclusions: The laser-induced ocular hypertension model in the present study produced a substantial reduction of retinal functions. Understanding the characteristic of pathological changes is crucial for further study using this model. © 2006 Royal Australian and New Zealand College of Ophthalmologists.en_US
dc.languageengen_US
dc.publisherWiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/CEOen_US
dc.relation.ispartofClinical and Experimental Ophthalmologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCell Counten_US
dc.subject.meshDark Adaptationen_US
dc.subject.meshDisease Models, Animalen_US
dc.subject.meshFemaleen_US
dc.subject.meshIntraocular Pressureen_US
dc.subject.meshLaser Coagulation - Adverse Effectsen_US
dc.subject.meshOcular Hypertension - Etiology - Physiopathologyen_US
dc.subject.meshPhotic Stimulationen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshRetina - Physiopathologyen_US
dc.subject.meshRetinal Ganglion Cells - Pathologyen_US
dc.titleChanges of retinal functions following the induction of ocular hypertension in rats using argon laser photocoagulationen_US
dc.typeArticleen_US
dc.identifier.emailTay, DK:dkctay@hkucc.hku.hken_US
dc.identifier.emailSo, KF:hrmaskf@hkucc.hku.hken_US
dc.identifier.authorityTay, DK=rp00336en_US
dc.identifier.authoritySo, KF=rp00329en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1111/j.1442-9071.2006.01279.xen_US
dc.identifier.pmid16925706-
dc.identifier.scopuseid_2-s2.0-33747365783en_US
dc.identifier.hkuros125778-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33747365783&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume34en_US
dc.identifier.issue6en_US
dc.identifier.spage575en_US
dc.identifier.epage583en_US
dc.identifier.isiWOS:000239798300013-
dc.publisher.placeAustraliaen_US
dc.identifier.scopusauthoridLi, RS=14056111900en_US
dc.identifier.scopusauthoridTay, DK=7006796825en_US
dc.identifier.scopusauthoridChan, HHL=24774420300en_US
dc.identifier.scopusauthoridSo, KF=34668391300en_US
dc.identifier.citeulike804598-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats