File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Expression and significance of glial fibrillry acidic protein in the plerosis of brachial plexus injury

TitleExpression and significance of glial fibrillry acidic protein in the plerosis of brachial plexus injury
Authors
Issue Date2006
Citation
Chinese Journal Of Clinical Rehabilitation, 2006, v. 10 n. 1, p. 100-102 How to Cite?
AbstractAim: To observe the expression of glial fibrillry acidic protein (GFAP) in the plerosis of brachial plexus injury and probe into its significance. Methods: The experiment was conducted in the Staff Room of Anatomy, Zhongshan Medical College, Sun Yat-sen University from September 2004 to March 2005. Sixty-five male adult SD rats were randomly divided into control group (n=5) and experimental group (n=60). Rats in the experimental group were made into three kinds of brachial plexus injury models: Right C 7 anterior root avulsion group (group A), C 7 anterior root avulsion with right C 5-T 1 posterior roots breaking group (group B), right C 7 anterior root avulsion with hemi-transect between C 5 and C 6 segment of spinal cord group (group C). Nerve anesthesia symptoms were assayed with combined behavioral score at the 1st, 3rd, 7th, 14th, days postoperatively. Immunohistochemical method and image analysis were used to observe the expression of GFAP in astrocytes of spinal cord in C 7 section. Results: Of 65 included rats in the experiment, one rats in the C 3 group of experimental group died 12 days after operation, and 64 rats were involved in the analysis of results. 1 Expression of GFAP in astrocytes after brachial plexus injury: Group A < group B < group C, and it was higher in these. 3 groups than that in the control group (Group A at the 1st, 3rd, 7th, 14th days were 141.5±2.1, 150.1°6.4, 158.4±5.0, 169.3±1.6 respectively; Group B were 156.7±1.9, 160.2±1.9, 172.5±3.5,190.1±3.2 respectively; Group C were 162.7±5.1, 183.3±1.7, 191.2±3.7, 228.7±4.2 respectively; Control group were 127.6±2.19, 127.6±2.19, 127.6±2.19, 127.6±2.19 respectively;P < 0.01). 2 Combined behavior score of each injured group showed a decreasing tendency from the 1st to the 14th day. 3 Expressions of GFAP in groups A, B, C were negatively correlated with combined behavior score of corresponding group (r=-0.956to-0.993, P < 0.01). Conclusion: The expression of GFAP induced by brachial plexus injury is increased progressively, which indicates that astrocytes take part in the whole process of nerve injury and repair.
Persistent Identifierhttp://hdl.handle.net/10722/149653
ISSN
2009 SCImago Journal Rankings: 0.105
References

 

DC FieldValueLanguage
dc.contributor.authorChen, LJen_US
dc.contributor.authorLi, Fen_US
dc.contributor.authorZhou, LHen_US
dc.contributor.authorWu, WTen_US
dc.contributor.authorPeng, YJen_US
dc.date.accessioned2012-06-26T05:56:36Z-
dc.date.available2012-06-26T05:56:36Z-
dc.date.issued2006en_US
dc.identifier.citationChinese Journal Of Clinical Rehabilitation, 2006, v. 10 n. 1, p. 100-102en_US
dc.identifier.issn1671-5926en_US
dc.identifier.urihttp://hdl.handle.net/10722/149653-
dc.description.abstractAim: To observe the expression of glial fibrillry acidic protein (GFAP) in the plerosis of brachial plexus injury and probe into its significance. Methods: The experiment was conducted in the Staff Room of Anatomy, Zhongshan Medical College, Sun Yat-sen University from September 2004 to March 2005. Sixty-five male adult SD rats were randomly divided into control group (n=5) and experimental group (n=60). Rats in the experimental group were made into three kinds of brachial plexus injury models: Right C 7 anterior root avulsion group (group A), C 7 anterior root avulsion with right C 5-T 1 posterior roots breaking group (group B), right C 7 anterior root avulsion with hemi-transect between C 5 and C 6 segment of spinal cord group (group C). Nerve anesthesia symptoms were assayed with combined behavioral score at the 1st, 3rd, 7th, 14th, days postoperatively. Immunohistochemical method and image analysis were used to observe the expression of GFAP in astrocytes of spinal cord in C 7 section. Results: Of 65 included rats in the experiment, one rats in the C 3 group of experimental group died 12 days after operation, and 64 rats were involved in the analysis of results. 1 Expression of GFAP in astrocytes after brachial plexus injury: Group A < group B < group C, and it was higher in these. 3 groups than that in the control group (Group A at the 1st, 3rd, 7th, 14th days were 141.5±2.1, 150.1°6.4, 158.4±5.0, 169.3±1.6 respectively; Group B were 156.7±1.9, 160.2±1.9, 172.5±3.5,190.1±3.2 respectively; Group C were 162.7±5.1, 183.3±1.7, 191.2±3.7, 228.7±4.2 respectively; Control group were 127.6±2.19, 127.6±2.19, 127.6±2.19, 127.6±2.19 respectively;P < 0.01). 2 Combined behavior score of each injured group showed a decreasing tendency from the 1st to the 14th day. 3 Expressions of GFAP in groups A, B, C were negatively correlated with combined behavior score of corresponding group (r=-0.956to-0.993, P < 0.01). Conclusion: The expression of GFAP induced by brachial plexus injury is increased progressively, which indicates that astrocytes take part in the whole process of nerve injury and repair.en_US
dc.languageengen_US
dc.relation.ispartofChinese Journal of Clinical Rehabilitationen_US
dc.titleExpression and significance of glial fibrillry acidic protein in the plerosis of brachial plexus injuryen_US
dc.typeArticleen_US
dc.identifier.emailWu, WT:wtwu@hkucc.hku.hken_US
dc.identifier.authorityWu, WT=rp00419en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.scopuseid_2-s2.0-33646074346en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-33646074346&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume10en_US
dc.identifier.issue1en_US
dc.identifier.spage100en_US
dc.identifier.epage102en_US
dc.identifier.scopusauthoridChen, LJ=17433588900en_US
dc.identifier.scopusauthoridLi, F=7406056863en_US
dc.identifier.scopusauthoridZhou, LH=7404125592en_US
dc.identifier.scopusauthoridWu, WT=7407081122en_US
dc.identifier.scopusauthoridPeng, YJ=16837209500en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats