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Article: Interferon-producing killer dendritic cells provide a link between innate and adaptive immunity

TitleInterferon-producing killer dendritic cells provide a link between innate and adaptive immunity
Authors
Issue Date2006
PublisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/nm
Citation
Nature Medicine, 2006, v. 12 n. 2, p. 207-213 How to Cite?
AbstractNatural killer (NK) cells and dendritic cells (DCs) are, respectively, central components of innate and adaptive immune responses 1,2. We describe here a third DC lineage, termed interferon-producing killer DCs (IKDCs), distinct from conventional DCs and plasmacytoid DCs and with the molecular expression profile of both NK cells and DCs. They produce substantial amounts of type I interferons (IFN) and interleukin (IL)-12 or IFN-γ, depending on activation stimuli. Upon stimulation with CpG oligodeoxynucleotides, ligands for Toll-like receptor (TLR)-9, IKDCs kill typical NK target cells using NK-activating receptors. Their cytolytic capacity subsequently diminishes, associated with the loss of NKG2D receptor (also known as Klrk1) and its adaptors, Dap10 and Dap12. As cytotoxicity is lost, DC-like antigen-presenting activity is gained, associated with upregulation of surface major histocompatibility complex class II (MHC II) and costimulatory molecules, which formally distinguish them from classical NK cells. In vivo, splenic IKDCs preferentially show NK function and, upon systemic infection, migrate to lymph nodes, where they primarily show antigen-presenting cell activity. By virtue of their capacity to kill target cells, followed by antigen presentation, IKDCs provide a link between innate and adaptive immunity. © 2006 Nature Publishing Group.
Persistent Identifierhttp://hdl.handle.net/10722/149649
ISSN
2015 Impact Factor: 30.357
2015 SCImago Journal Rankings: 13.959
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, CWen_US
dc.contributor.authorCrafton, Een_US
dc.contributor.authorFan, HNen_US
dc.contributor.authorFlook, Jen_US
dc.contributor.authorYoshimura, Ken_US
dc.contributor.authorSkarica, Men_US
dc.contributor.authorBrockstedt, Den_US
dc.contributor.authorDubensky, TWen_US
dc.contributor.authorStins, MFen_US
dc.contributor.authorLanier, LLen_US
dc.contributor.authorPardoll, DMen_US
dc.contributor.authorHousseau, Fen_US
dc.date.accessioned2012-06-26T05:56:31Z-
dc.date.available2012-06-26T05:56:31Z-
dc.date.issued2006en_US
dc.identifier.citationNature Medicine, 2006, v. 12 n. 2, p. 207-213en_US
dc.identifier.issn1078-8956en_US
dc.identifier.urihttp://hdl.handle.net/10722/149649-
dc.description.abstractNatural killer (NK) cells and dendritic cells (DCs) are, respectively, central components of innate and adaptive immune responses 1,2. We describe here a third DC lineage, termed interferon-producing killer DCs (IKDCs), distinct from conventional DCs and plasmacytoid DCs and with the molecular expression profile of both NK cells and DCs. They produce substantial amounts of type I interferons (IFN) and interleukin (IL)-12 or IFN-γ, depending on activation stimuli. Upon stimulation with CpG oligodeoxynucleotides, ligands for Toll-like receptor (TLR)-9, IKDCs kill typical NK target cells using NK-activating receptors. Their cytolytic capacity subsequently diminishes, associated with the loss of NKG2D receptor (also known as Klrk1) and its adaptors, Dap10 and Dap12. As cytotoxicity is lost, DC-like antigen-presenting activity is gained, associated with upregulation of surface major histocompatibility complex class II (MHC II) and costimulatory molecules, which formally distinguish them from classical NK cells. In vivo, splenic IKDCs preferentially show NK function and, upon systemic infection, migrate to lymph nodes, where they primarily show antigen-presenting cell activity. By virtue of their capacity to kill target cells, followed by antigen presentation, IKDCs provide a link between innate and adaptive immunity. © 2006 Nature Publishing Group.en_US
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.nature.com/nmen_US
dc.relation.ispartofNature Medicineen_US
dc.subject.meshAdaptation, Physiologicalen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAntigen Presentationen_US
dc.subject.meshCell Line, Tumoren_US
dc.subject.meshCytotoxicity, Immunologicen_US
dc.subject.meshDendritic Cells - Classification - Immunology - Ultrastructureen_US
dc.subject.meshGene Expressionen_US
dc.subject.meshImmunity, Innateen_US
dc.subject.meshInterferons - Biosynthesisen_US
dc.subject.meshKiller Cells, Natural - Classification - Immunology - Ultrastructureen_US
dc.subject.meshListeria Monocytogenes - Immunologyen_US
dc.subject.meshMiceen_US
dc.subject.meshMice, Inbred Balb Cen_US
dc.subject.meshMice, Inbred C57blen_US
dc.subject.meshMice, Inbred Dbaen_US
dc.subject.meshMice, Knockouten_US
dc.subject.meshMice, Transgenicen_US
dc.subject.meshOligodeoxyribonucleotides - Pharmacologyen_US
dc.titleInterferon-producing killer dendritic cells provide a link between innate and adaptive immunityen_US
dc.typeArticleen_US
dc.identifier.emailChan, CW:camchan@hku.hken_US
dc.identifier.authorityChan, CW=rp01311en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1038/nm1352en_US
dc.identifier.pmid16444266-
dc.identifier.scopuseid_2-s2.0-32244448339en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-32244448339&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume12en_US
dc.identifier.issue2en_US
dc.identifier.spage207en_US
dc.identifier.epage213en_US
dc.identifier.eissn1546-170X-
dc.identifier.isiWOS:000235160600025-
dc.publisher.placeUnited Statesen_US
dc.identifier.f10001030695-
dc.identifier.scopusauthoridChan, CW=12240386600en_US
dc.identifier.scopusauthoridCrafton, E=6506443639en_US
dc.identifier.scopusauthoridFan, HN=7402553804en_US
dc.identifier.scopusauthoridFlook, J=55192251300en_US
dc.identifier.scopusauthoridYoshimura, K=8632517000en_US
dc.identifier.scopusauthoridSkarica, M=12240073000en_US
dc.identifier.scopusauthoridBrockstedt, D=6603464986en_US
dc.identifier.scopusauthoridDubensky, TW=7004538960en_US
dc.identifier.scopusauthoridStins, MF=7003324243en_US
dc.identifier.scopusauthoridLanier, LL=16473325100en_US
dc.identifier.scopusauthoridPardoll, DM=7005961020en_US
dc.identifier.scopusauthoridHousseau, F=6603256765en_US
dc.identifier.citeulike494926-

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