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Article: Expression of CNTFs in facial motoneurons during facial nerve regeneration in rats and their association with TGF-beta and rhBMP-2

TitleExpression of CNTFs in facial motoneurons during facial nerve regeneration in rats and their association with TGF-beta and rhBMP-2
Authors
Nie, XJin, YTipoe, GL
Issue Date2003
PublisherSichuan Daxue, Huaxi Kouqiang Xueyuan. The Journal's web site is located at http://hxkqyxzz.periodicals.net.cn/
Citation
Hua Xi Kou Qiang Yi Xue Za Zhi = Huaxi Kouqiang Yixue Zazhi = West China Journal Of Stomatology, 2003, v. 21 n. 1, p. 52-54 How to Cite?
AbstractOBJECTIVE: The aim of this study was to observe the expression of ciliary neurotrophic factors (CNTFs) in the facial motor neurons in rats during facial nerve regeneration. METHODS: The expression amount of CNTFs in eight groups was determined with immunohistochemical staining and image analysis. RESULTS: The expression of CNTFs increased during the process of nerve regeneration, and reached the maximum one-week and one-month after nerve injury respectively. After one month, the intensity of CNTFs reduced gradually. The expression of recombinant human bone morphogenetic protein-2 (rhBMP-2) did not show distinct difference comparing with the control, but beta transforming growth factors (TGF-beta) benefited the expression of CNTFs during nerve regeneration. CONCLUSION: The endogenous CNTFs promotes the axon outgrow during regeneration, and TGF-beta promotes the expression of CNTFs to rescue motoneuron during facial nerve regeneration.
Persistent Identifierhttp://hdl.handle.net/10722/149647
ISSN
1000-1182
2023 SCImago Journal Rankings: 0.177

 

DC FieldValueLanguage
dc.contributor.authorNie, Xen_US
dc.contributor.authorJin, Yen_US
dc.contributor.authorTipoe, GLen_US
dc.date.accessioned2012-06-26T05:56:29Z-
dc.date.available2012-06-26T05:56:29Z-
dc.date.issued2003en_US
dc.identifier.citationHua Xi Kou Qiang Yi Xue Za Zhi = Huaxi Kouqiang Yixue Zazhi = West China Journal Of Stomatology, 2003, v. 21 n. 1, p. 52-54en_US
dc.identifier.issn1000-1182en_US
dc.identifier.urihttp://hdl.handle.net/10722/149647-
dc.description.abstractOBJECTIVE: The aim of this study was to observe the expression of ciliary neurotrophic factors (CNTFs) in the facial motor neurons in rats during facial nerve regeneration. METHODS: The expression amount of CNTFs in eight groups was determined with immunohistochemical staining and image analysis. RESULTS: The expression of CNTFs increased during the process of nerve regeneration, and reached the maximum one-week and one-month after nerve injury respectively. After one month, the intensity of CNTFs reduced gradually. The expression of recombinant human bone morphogenetic protein-2 (rhBMP-2) did not show distinct difference comparing with the control, but beta transforming growth factors (TGF-beta) benefited the expression of CNTFs during nerve regeneration. CONCLUSION: The endogenous CNTFs promotes the axon outgrow during regeneration, and TGF-beta promotes the expression of CNTFs to rescue motoneuron during facial nerve regeneration.en_US
dc.languageengen_US
dc.publisherSichuan Daxue, Huaxi Kouqiang Xueyuan. The Journal's web site is located at http://hxkqyxzz.periodicals.net.cn/en_US
dc.relation.ispartofHua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBone Morphogenetic Proteins - Metabolismen_US
dc.subject.meshCiliary Neurotrophic Factor - Biosynthesis - Geneticsen_US
dc.subject.meshFacial Nerve - Metabolism - Physiopathologyen_US
dc.subject.meshFacial Nerve Injuries - Physiopathologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMotor Neurons - Metabolismen_US
dc.subject.meshNerve Regenerationen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshRecombinant Proteinsen_US
dc.subject.meshTransforming Growth Factor Beta - Metabolismen_US
dc.titleExpression of CNTFs in facial motoneurons during facial nerve regeneration in rats and their association with TGF-beta and rhBMP-2en_US
dc.typeArticleen_US
dc.identifier.emailTipoe, GL:tgeorge@hkucc.hku.hken_US
dc.identifier.authorityTipoe, GL=rp00371en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid12674624-
dc.identifier.scopuseid_2-s2.0-3142648908en_US
dc.identifier.volume21en_US
dc.identifier.issue1en_US
dc.identifier.spage52en_US
dc.identifier.epage54en_US
dc.publisher.placeChinaen_US
dc.identifier.scopusauthoridNie, X=7103207433en_US
dc.identifier.scopusauthoridJin, Y=26643271200en_US
dc.identifier.scopusauthoridTipoe, GL=7003550610en_US
dc.identifier.issnl1000-1182-

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