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Article: Overexpression of Id-1 in Gastric Adenocarcinoma: Implication for a Novel Diagnostic Marker

TitleOverexpression of Id-1 in Gastric Adenocarcinoma: Implication for a Novel Diagnostic Marker
Authors
Issue Date2004
Citation
Anticancer Research, 2004, v. 24 n. 2 B, p. 881-886 How to Cite?
AbstractGastric cancer is the second most common cause of cancer-related death worldwide and the highest incidence of this cancer has been reported in Asia, especially in China. Identification of early stage lesions is vital in achieving high survival rate. However, due to the lack of reliable biomarkers, the majority of gastric cancer is presented at an advanced stage. Recently, it has been reported that Id-1, a helix-loop-helix protein, may be a valuable diagnostic marker in many types of human cancer. In this study, we evaluated Id-1 protein expression in gastric cancer specimens and compared it with non-malignant tissues. In addition, to investigate whether Id-1 expression levels were associated with the aggressiveness of this disease as implicated in other cancer types, we also assessed Id-1 expression levels in primary tumours and their lymph node metastasized lesions. Our results indicate that up-regulation of Id-1 is a frequent event in gastric cancer but its expression levels are not associated with tumour metastasis. Our evidence provides a possible novel marker for the diagnosis of gastric cancer.
Persistent Identifierhttp://hdl.handle.net/10722/149641
ISSN
2015 Impact Factor: 1.895
2015 SCImago Journal Rankings: 0.815
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorWang, Qen_US
dc.contributor.authorTsao, SWen_US
dc.contributor.authorFu, Sen_US
dc.contributor.authorXue, Wen_US
dc.contributor.authorMeng, Xen_US
dc.contributor.authorFeng, Hen_US
dc.contributor.authorWong, YCen_US
dc.contributor.authorWang, Xen_US
dc.date.accessioned2012-06-26T05:56:24Z-
dc.date.available2012-06-26T05:56:24Z-
dc.date.issued2004en_US
dc.identifier.citationAnticancer Research, 2004, v. 24 n. 2 B, p. 881-886en_US
dc.identifier.issn0250-7005en_US
dc.identifier.urihttp://hdl.handle.net/10722/149641-
dc.description.abstractGastric cancer is the second most common cause of cancer-related death worldwide and the highest incidence of this cancer has been reported in Asia, especially in China. Identification of early stage lesions is vital in achieving high survival rate. However, due to the lack of reliable biomarkers, the majority of gastric cancer is presented at an advanced stage. Recently, it has been reported that Id-1, a helix-loop-helix protein, may be a valuable diagnostic marker in many types of human cancer. In this study, we evaluated Id-1 protein expression in gastric cancer specimens and compared it with non-malignant tissues. In addition, to investigate whether Id-1 expression levels were associated with the aggressiveness of this disease as implicated in other cancer types, we also assessed Id-1 expression levels in primary tumours and their lymph node metastasized lesions. Our results indicate that up-regulation of Id-1 is a frequent event in gastric cancer but its expression levels are not associated with tumour metastasis. Our evidence provides a possible novel marker for the diagnosis of gastric cancer.en_US
dc.languageengen_US
dc.relation.ispartofAnticancer Researchen_US
dc.subject.meshAdenocarcinoma - Metabolism - Pathologyen_US
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshInhibitor Of Differentiation Protein 1en_US
dc.subject.meshLymphatic Metastasisen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshRepressor Proteinsen_US
dc.subject.meshStomach Neoplasms - Metabolism - Pathologyen_US
dc.subject.meshTranscription Factors - Biosynthesisen_US
dc.subject.meshTumor Markers, Biological - Biosynthesisen_US
dc.titleOverexpression of Id-1 in Gastric Adenocarcinoma: Implication for a Novel Diagnostic Markeren_US
dc.typeArticleen_US
dc.identifier.emailTsao, SW:gswtsao@hkucc.hku.hken_US
dc.identifier.emailWong, YC:ycwong@hkucc.hku.hken_US
dc.identifier.authorityTsao, SW=rp00399en_US
dc.identifier.authorityWong, YC=rp00316en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.pmid15161041-
dc.identifier.scopuseid_2-s2.0-2442417951en_US
dc.identifier.hkuros88942-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-2442417951&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume24en_US
dc.identifier.issue2 Ben_US
dc.identifier.spage881en_US
dc.identifier.epage886en_US
dc.identifier.isiWOS:000221385000051-
dc.publisher.placeGreeceen_US
dc.identifier.scopusauthoridWang, Q=7406910452en_US
dc.identifier.scopusauthoridTsao, SW=7102813116en_US
dc.identifier.scopusauthoridFu, S=7402732420en_US
dc.identifier.scopusauthoridXue, W=7103165268en_US
dc.identifier.scopusauthoridMeng, X=7401629950en_US
dc.identifier.scopusauthoridFeng, H=7401736336en_US
dc.identifier.scopusauthoridWong, YC=7403041798en_US
dc.identifier.scopusauthoridWang, X=7501854829en_US

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