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Article: Elevated levels of transforming growth factor-β1 in serum of patients with stable bronchiectasis

TitleElevated levels of transforming growth factor-β1 in serum of patients with stable bronchiectasis
Authors
KeywordsBronchiectasis
Serum
Transforming growth factor-β1
Issue Date2005
PublisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/rmed
Citation
Respiratory Medicine, 2005, v. 99 n. 10, p. 1223-1228 How to Cite?
Abstract
Bronchiectasis is a chronic inflammatory and infective airway disease characterized by irreversible dilatation of the bronchi and persistent purulent sputum. Transforming growth factor-β1 (TGF-β1) has been found to be increased in the lungs or bronchoalveolar lavage fluid of patients with inflammatory lung diseases. However, little is known on the serum TGF-β1 levels in patients with bronchiectasis. We aimed to determine the serum TGF-β1 concentrations in 95 patients with stable bronchiectasis (63 women; mean±SD age, 58.9±14.1 years) and 68 control subjects (23 women; 48.9±12.8 years) by ELISA, and to correlate with clinical parameters. The serum TGF-β1 levels were significantly higher in bronchiectatic patients compared with control subjects (median [range], 1812.5 pg/ml [1226.4-4114.5 pg/ml] vs. 1342.4 pg/ml [940.3-2371.7 pg/ml]; P < 0.001). There was, however, no correlation between serum TGF-β1 levels with FEV1 (% predicted), FVC (% predicted), 24 h sputum volume, the number of bronchiectatic lung lobes or total white blood cell count (P>0.05). Our findings support previous indications that TGF-β1 may contribute to bronchiectatic airway inflammation. Further studies on the potential mechanisms and pathogenesis implications of this elevation should also be pursued in future. © 2005 Elsevier Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/149640
ISSN
2013 Impact Factor: 2.917
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorMak, JCWen_HK
dc.contributor.authorHo, SPen_HK
dc.contributor.authorLeung, RYHen_HK
dc.contributor.authorHo, PLen_HK
dc.contributor.authorOoi, Cen_HK
dc.contributor.authorTipoe, GLen_HK
dc.contributor.authorYan, Cen_HK
dc.contributor.authorIp, MSMen_HK
dc.contributor.authorLam, WKen_HK
dc.contributor.authorTsang, KWTen_HK
dc.date.accessioned2012-06-26T05:56:23Z-
dc.date.available2012-06-26T05:56:23Z-
dc.date.issued2005en_HK
dc.identifier.citationRespiratory Medicine, 2005, v. 99 n. 10, p. 1223-1228en_HK
dc.identifier.issn0954-6111en_HK
dc.identifier.urihttp://hdl.handle.net/10722/149640-
dc.description.abstractBronchiectasis is a chronic inflammatory and infective airway disease characterized by irreversible dilatation of the bronchi and persistent purulent sputum. Transforming growth factor-β1 (TGF-β1) has been found to be increased in the lungs or bronchoalveolar lavage fluid of patients with inflammatory lung diseases. However, little is known on the serum TGF-β1 levels in patients with bronchiectasis. We aimed to determine the serum TGF-β1 concentrations in 95 patients with stable bronchiectasis (63 women; mean±SD age, 58.9±14.1 years) and 68 control subjects (23 women; 48.9±12.8 years) by ELISA, and to correlate with clinical parameters. The serum TGF-β1 levels were significantly higher in bronchiectatic patients compared with control subjects (median [range], 1812.5 pg/ml [1226.4-4114.5 pg/ml] vs. 1342.4 pg/ml [940.3-2371.7 pg/ml]; P < 0.001). There was, however, no correlation between serum TGF-β1 levels with FEV1 (% predicted), FVC (% predicted), 24 h sputum volume, the number of bronchiectatic lung lobes or total white blood cell count (P>0.05). Our findings support previous indications that TGF-β1 may contribute to bronchiectatic airway inflammation. Further studies on the potential mechanisms and pathogenesis implications of this elevation should also be pursued in future. © 2005 Elsevier Ltd. All rights reserved.en_HK
dc.languageengen_US
dc.publisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/rmeden_HK
dc.relation.ispartofRespiratory Medicineen_HK
dc.subjectBronchiectasisen_HK
dc.subjectSerumen_HK
dc.subjectTransforming growth factor-β1en_HK
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshBronchiectasis - Blood - Etiologyen_US
dc.subject.meshCase-Control Studiesen_US
dc.subject.meshChinaen_US
dc.subject.meshEnzyme-Linked Immunosorbent Assayen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshMaleen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshTransforming Growth Factor Beta - Metabolismen_US
dc.subject.meshTransforming Growth Factor Beta1en_US
dc.titleElevated levels of transforming growth factor-β1 in serum of patients with stable bronchiectasisen_HK
dc.typeArticleen_HK
dc.identifier.emailMak, JCW:judymak@hku.hken_HK
dc.identifier.emailHo, PL:plho@hkucc.hku.hken_HK
dc.identifier.emailTipoe, GL:tgeorge@hkucc.hku.hken_HK
dc.identifier.emailIp, MSM:msmip@hku.hken_HK
dc.identifier.authorityMak, JCW=rp00352en_HK
dc.identifier.authorityHo, PL=rp00406en_HK
dc.identifier.authorityTipoe, GL=rp00371en_HK
dc.identifier.authorityIp, MSM=rp00347en_HK
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.rmed.2005.02.039en_HK
dc.identifier.pmid16140222en_HK
dc.identifier.scopuseid_2-s2.0-24344442810en_HK
dc.identifier.hkuros118977-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-24344442810&selection=ref&src=s&origin=recordpageen_HK
dc.identifier.volume99en_HK
dc.identifier.issue10en_HK
dc.identifier.spage1223en_HK
dc.identifier.epage1228en_HK
dc.identifier.isiWOS:000232182500004-
dc.publisher.placeUnited Kingdomen_HK
dc.identifier.scopusauthoridMak, JCW=7103323094en_HK
dc.identifier.scopusauthoridHo, SP=12794365900en_HK
dc.identifier.scopusauthoridLeung, RYH=7101876102en_HK
dc.identifier.scopusauthoridHo, PL=7402211363en_HK
dc.identifier.scopusauthoridOoi, C=7007084909en_HK
dc.identifier.scopusauthoridTipoe, GL=7003550610en_HK
dc.identifier.scopusauthoridYan, C=8728540500en_HK
dc.identifier.scopusauthoridIp, MSM=7102423259en_HK
dc.identifier.scopusauthoridLam, WK=7203021937en_HK
dc.identifier.scopusauthoridTsang, KWT=7201555024en_HK

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