Article: Elevated levels of transforming growth factor-β1 in serum of patients with stable bronchiectasis

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TitleElevated levels of transforming growth factor-β1 in serum of patients with stable bronchiectasis
AuthorsMak, JCW1
Ho, SP1
Leung, RYH1
Ho, PL1
Ooi, C1
Tipoe, GL1
Yan, C1
Ip, MSM1
Lam, WK1
Tsang, KWT1
KeywordsBronchiectasis
Serum
Transforming growth factor-β1
Issue Date2005
PublisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/rmed
CitationRespiratory Medicine, 2005, v. 99 n. 10, p. 1223-1228 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.rmed.2005.02.039
AbstractBronchiectasis is a chronic inflammatory and infective airway disease characterized by irreversible dilatation of the bronchi and persistent purulent sputum. Transforming growth factor-β1 (TGF-β1) has been found to be increased in the lungs or bronchoalveolar lavage fluid of patients with inflammatory lung diseases. However, little is known on the serum TGF-β1 levels in patients with bronchiectasis. We aimed to determine the serum TGF-β1 concentrations in 95 patients with stable bronchiectasis (63 women; mean±SD age, 58.9±14.1 years) and 68 control subjects (23 women; 48.9±12.8 years) by ELISA, and to correlate with clinical parameters. The serum TGF-β1 levels were significantly higher in bronchiectatic patients compared with control subjects (median [range], 1812.5 pg/ml [1226.4-4114.5 pg/ml] vs. 1342.4 pg/ml [940.3-2371.7 pg/ml]; P < 0.001). There was, however, no correlation between serum TGF-β1 levels with FEV1 (% predicted), FVC (% predicted), 24 h sputum volume, the number of bronchiectatic lung lobes or total white blood cell count (P>0.05). Our findings support previous indications that TGF-β1 may contribute to bronchiectatic airway inflammation. Further studies on the potential mechanisms and pathogenesis implications of this elevation should also be pursued in future. © 2005 Elsevier Ltd. All rights reserved.
ISSN0954-6111
2011 Impact Factor: 2.475
2011 SCImago Journal Rankings: 0.213
DOIhttp://dx.doi.org/10.1016/j.rmed.2005.02.039
ReferencesReferences in Scopus
DC Field
Value
dc.contributor.authorMak, JCW
dc.contributor.authorHo, SP
dc.contributor.authorLeung, RYH
dc.contributor.authorHo, PL
dc.contributor.authorOoi, C
dc.contributor.authorTipoe, GL
dc.contributor.authorYan, C
dc.contributor.authorIp, MSM
dc.contributor.authorLam, WK
dc.contributor.authorTsang, KWT
dc.date.accessioned2012-06-26T05:56:23Z
dc.date.available2012-06-26T05:56:23Z
dc.date.issued2005
dc.description.abstractBronchiectasis is a chronic inflammatory and infective airway disease characterized by irreversible dilatation of the bronchi and persistent purulent sputum. Transforming growth factor-β1 (TGF-β1) has been found to be increased in the lungs or bronchoalveolar lavage fluid of patients with inflammatory lung diseases. However, little is known on the serum TGF-β1 levels in patients with bronchiectasis. We aimed to determine the serum TGF-β1 concentrations in 95 patients with stable bronchiectasis (63 women; mean±SD age, 58.9±14.1 years) and 68 control subjects (23 women; 48.9±12.8 years) by ELISA, and to correlate with clinical parameters. The serum TGF-β1 levels were significantly higher in bronchiectatic patients compared with control subjects (median [range], 1812.5 pg/ml [1226.4-4114.5 pg/ml] vs. 1342.4 pg/ml [940.3-2371.7 pg/ml]; P < 0.001). There was, however, no correlation between serum TGF-β1 levels with FEV1 (% predicted), FVC (% predicted), 24 h sputum volume, the number of bronchiectatic lung lobes or total white blood cell count (P>0.05). Our findings support previous indications that TGF-β1 may contribute to bronchiectatic airway inflammation. Further studies on the potential mechanisms and pathogenesis implications of this elevation should also be pursued in future. © 2005 Elsevier Ltd. All rights reserved.
dc.description.natureLink_to_subscribed_fulltext
dc.identifier.citationRespiratory Medicine, 2005, v. 99 n. 10, p. 1223-1228 [How to Cite?]
DOI: http://dx.doi.org/10.1016/j.rmed.2005.02.039
dc.identifier.doihttp://dx.doi.org/10.1016/j.rmed.2005.02.039
dc.identifier.epage1228
dc.identifier.hkuros118977
dc.identifier.isiWOS:000232182500004
dc.identifier.issn0954-6111
2011 Impact Factor: 2.475
2011 SCImago Journal Rankings: 0.213
dc.identifier.issue10
dc.identifier.pmid16140222
dc.identifier.scopuseid_2-s2.0-24344442810
dc.identifier.spage1223
dc.identifier.urihttp://hdl.handle.net/10722/149640
dc.identifier.volume99
dc.languageeng
dc.publisherElsevier Ltd. The Journal's web site is located at http://www.elsevier.com/locate/rmed
dc.publisher.placeUnited Kingdom
dc.relation.ispartofRespiratory Medicine
dc.relation.referencesReferences in Scopus
dc.subject.meshAdult
dc.subject.meshAged
dc.subject.meshBronchiectasis - Blood - Etiology
dc.subject.meshCase-Control Studies
dc.subject.meshChina
dc.subject.meshEnzyme-Linked Immunosorbent Assay
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshTransforming Growth Factor Beta - Metabolism
dc.subject.meshTransforming Growth Factor Beta1
dc.subjectBronchiectasis
dc.subjectSerum
dc.subjectTransforming growth factor-β1
dc.titleElevated levels of transforming growth factor-β1 in serum of patients with stable bronchiectasis
dc.typeArticle
Author Affiliations
  1. The University of Hong Kong