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Article: Different optic nerve injury sites result in different responses of retinal ganglion cells to brain-derived neurotrophic factor but not neurotrophin-4/5

TitleDifferent optic nerve injury sites result in different responses of retinal ganglion cells to brain-derived neurotrophic factor but not neurotrophin-4/5
Authors
Issue Date2005
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainres
Citation
Brain Research, 2005, v. 1047 n. 2, p. 224-232 How to Cite?
AbstractIn this study, we investigated whether brain-derived neurotrophic factor (BDNF) and neurotrophin-4/5 (NT-4/5) can achieve prolonged protection on retinal ganglion cells (RGCs) and whether site of axon injury modulates RGC response to neurotrophins. Two optic nerve (ON) injury paradigms, proximal and distal transections, were used. Autologous sciatic nerves were grafted onto ON stump in some animals to provide a suitable environment for axons to regrow. Multiple intravitreal injections of saline, BDNF, or NT-4/5 were performed. Immunohistochemistry was used to determine the proportion of RGCs that were expressing trkB. Twenty days after proximal injury, both BDNF and NT-4/5 promoted RGC survival; this protection diminished 30 days after injury. One month after distal injury, BDNF, but not NT-4/5, promoted RGC survival (by 2-fold). No difference in the proportion of trkB expressing RGCs among the viable ones was seen between the two injury models or after BDNF treatment. Interestingly, the mean size of RGC somata was larger after proximal injury than distal injury. This study demonstrates that (1) RGCs respond differently to neurotrophins under different injury conditions, (2) BDNF but not NT-4/5 significantly enhances survival of distally but not proximally injured RGCs over a prolonged period. © 2005 Elsevier B.V. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/149636
ISSN
2015 Impact Factor: 2.561
2015 SCImago Journal Rankings: 1.351
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorZhi, Yen_US
dc.contributor.authorLu, Qen_US
dc.contributor.authorZhang, CWen_US
dc.contributor.authorYip, HKen_US
dc.contributor.authorSo, KFen_US
dc.contributor.authorCui, Qen_US
dc.date.accessioned2012-06-26T05:56:20Z-
dc.date.available2012-06-26T05:56:20Z-
dc.date.issued2005en_US
dc.identifier.citationBrain Research, 2005, v. 1047 n. 2, p. 224-232en_US
dc.identifier.issn0006-8993en_US
dc.identifier.urihttp://hdl.handle.net/10722/149636-
dc.description.abstractIn this study, we investigated whether brain-derived neurotrophic factor (BDNF) and neurotrophin-4/5 (NT-4/5) can achieve prolonged protection on retinal ganglion cells (RGCs) and whether site of axon injury modulates RGC response to neurotrophins. Two optic nerve (ON) injury paradigms, proximal and distal transections, were used. Autologous sciatic nerves were grafted onto ON stump in some animals to provide a suitable environment for axons to regrow. Multiple intravitreal injections of saline, BDNF, or NT-4/5 were performed. Immunohistochemistry was used to determine the proportion of RGCs that were expressing trkB. Twenty days after proximal injury, both BDNF and NT-4/5 promoted RGC survival; this protection diminished 30 days after injury. One month after distal injury, BDNF, but not NT-4/5, promoted RGC survival (by 2-fold). No difference in the proportion of trkB expressing RGCs among the viable ones was seen between the two injury models or after BDNF treatment. Interestingly, the mean size of RGC somata was larger after proximal injury than distal injury. This study demonstrates that (1) RGCs respond differently to neurotrophins under different injury conditions, (2) BDNF but not NT-4/5 significantly enhances survival of distally but not proximally injured RGCs over a prolonged period. © 2005 Elsevier B.V. All rights reserved.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/brainresen_US
dc.relation.ispartofBrain Researchen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAxotomyen_US
dc.subject.meshBrain-Derived Neurotrophic Factor - Administration & Dosageen_US
dc.subject.meshCell Size - Drug Effectsen_US
dc.subject.meshCell Survival - Drug Effectsen_US
dc.subject.meshCricetinaeen_US
dc.subject.meshImmunohistochemistryen_US
dc.subject.meshNeuroprotective Agents - Administration & Dosageen_US
dc.subject.meshOptic Nerve - Surgeryen_US
dc.subject.meshOptic Nerve Injuriesen_US
dc.subject.meshReceptor, Trkb - Biosynthesis - Drug Effectsen_US
dc.subject.meshReceptors, Nerve Growth Factor - Administration & Dosageen_US
dc.subject.meshRetinal Ganglion Cells - Drug Effectsen_US
dc.subject.meshSciatic Nerve - Transplantationen_US
dc.subject.meshTime Factorsen_US
dc.titleDifferent optic nerve injury sites result in different responses of retinal ganglion cells to brain-derived neurotrophic factor but not neurotrophin-4/5en_US
dc.typeArticleen_US
dc.identifier.emailYip, HK:hkfyip@hku.hken_US
dc.identifier.emailSo, KF:hrmaskf@hkucc.hku.hken_US
dc.identifier.authorityYip, HK=rp00285en_US
dc.identifier.authoritySo, KF=rp00329en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.brainres.2005.04.037en_US
dc.identifier.pmid15904902-
dc.identifier.scopuseid_2-s2.0-20444364143en_US
dc.identifier.hkuros108616-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-20444364143&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume1047en_US
dc.identifier.issue2en_US
dc.identifier.spage224en_US
dc.identifier.epage232en_US
dc.identifier.isiWOS:000230076500010-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridZhi, Y=8618487800en_US
dc.identifier.scopusauthoridLu, Q=54902894100en_US
dc.identifier.scopusauthoridZhang, CW=8226423900en_US
dc.identifier.scopusauthoridYip, HK=7101980864en_US
dc.identifier.scopusauthoridSo, KF=34668391300en_US
dc.identifier.scopusauthoridCui, Q=7103080164en_US

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