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Article: Immune modulatory effects of Prunella vulgaris L.

TitleImmune modulatory effects of Prunella vulgaris L.
Authors
Issue Date2005
PublisherDemetrios A Spandidos Ed & Pub. The Journal's web site is located at http://147.52.72.117/IJMM/ijmm.htm
Citation
International Journal Of Molecular Medicine, 2005, v. 15 n. 3, p. 491-496 How to Cite?
AbstractPrunella vulgaris L. (Labiatae) is a perennial plant known as 'self-heal' in Western herbal medicine. It has a wide array of biological effects exhibiting numerous therapeutic potentials. Its anti-microbial effects including anti-viral and anti-bacterial effects are, presently, receiving increasing attention. While its anti-viral effects are attributed mainly to the inhibition of virus replication, the biological mechanisms of its anti-bacterial effects or actions remain unknown. In view of the fact that polysaccharides isolated from medicinal herbs often function as biological response modifier of body immunity, we hypothesized that the anti-microbial effect of polysaccharides isolated from P. vulgaris is probably also mediated via immune modulation. We have isolated four polysaccharides containing fractions from P. vulgaris, one of the fractions, PV2, could markedly stimulate the production of superoxide and nitrite representing nitric oxide from murine macrophage RAW264.7 and brain macrophage BV2 cells. The amount of nitrite and superoxide produced after PV2 stimulation was as high as that seen in stimulation using bacterial endotoxin lipopolysaccharide (LPS), and this stimulatory response is dose-dependent. In addition to monocyte/macrophage, PV2 also stimulated the proliferation of splenocytes. In this study, we have shown that the polysaccharides isolated from P. vulgaris have marked immune stimulatory effects, which may bring about the anti-microbial effects of P. vulgaris.
Persistent Identifierhttp://hdl.handle.net/10722/149634
ISSN
2015 Impact Factor: 2.348
2015 SCImago Journal Rankings: 0.868
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorFang, Xen_US
dc.contributor.authorChang, RCen_US
dc.contributor.authorYuen, WHen_US
dc.contributor.authorZee, SYen_US
dc.date.accessioned2012-06-26T05:56:19Z-
dc.date.available2012-06-26T05:56:19Z-
dc.date.issued2005en_US
dc.identifier.citationInternational Journal Of Molecular Medicine, 2005, v. 15 n. 3, p. 491-496en_US
dc.identifier.issn1107-3756en_US
dc.identifier.urihttp://hdl.handle.net/10722/149634-
dc.description.abstractPrunella vulgaris L. (Labiatae) is a perennial plant known as 'self-heal' in Western herbal medicine. It has a wide array of biological effects exhibiting numerous therapeutic potentials. Its anti-microbial effects including anti-viral and anti-bacterial effects are, presently, receiving increasing attention. While its anti-viral effects are attributed mainly to the inhibition of virus replication, the biological mechanisms of its anti-bacterial effects or actions remain unknown. In view of the fact that polysaccharides isolated from medicinal herbs often function as biological response modifier of body immunity, we hypothesized that the anti-microbial effect of polysaccharides isolated from P. vulgaris is probably also mediated via immune modulation. We have isolated four polysaccharides containing fractions from P. vulgaris, one of the fractions, PV2, could markedly stimulate the production of superoxide and nitrite representing nitric oxide from murine macrophage RAW264.7 and brain macrophage BV2 cells. The amount of nitrite and superoxide produced after PV2 stimulation was as high as that seen in stimulation using bacterial endotoxin lipopolysaccharide (LPS), and this stimulatory response is dose-dependent. In addition to monocyte/macrophage, PV2 also stimulated the proliferation of splenocytes. In this study, we have shown that the polysaccharides isolated from P. vulgaris have marked immune stimulatory effects, which may bring about the anti-microbial effects of P. vulgaris.en_US
dc.languageengen_US
dc.publisherDemetrios A Spandidos Ed & Pub. The Journal's web site is located at http://147.52.72.117/IJMM/ijmm.htmen_US
dc.relation.ispartofInternational journal of molecular medicineen_US
dc.subject.meshAnimalsen_US
dc.subject.meshCell Proliferation - Drug Effectsen_US
dc.subject.meshCells, Cultureden_US
dc.subject.meshMacrophages - Drug Effects - Immunology - Metabolismen_US
dc.subject.meshMiceen_US
dc.subject.meshMicroglia - Drug Effects - Immunology - Metabolismen_US
dc.subject.meshNitrites - Metabolismen_US
dc.subject.meshPlant Extracts - Immunology - Pharmacologyen_US
dc.subject.meshPrunella - Chemistryen_US
dc.subject.meshSpleen - Cytology - Drug Effectsen_US
dc.subject.meshSuperoxides - Metabolismen_US
dc.titleImmune modulatory effects of Prunella vulgaris L.en_US
dc.typeArticleen_US
dc.identifier.emailChang, RC:rccchang@hkucc.hku.hken_US
dc.identifier.authorityChang, RC=rp00470en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid15702244-
dc.identifier.scopuseid_2-s2.0-19644395908en_US
dc.identifier.hkuros97465-
dc.identifier.volume15en_US
dc.identifier.issue3en_US
dc.identifier.spage491en_US
dc.identifier.epage496en_US
dc.identifier.isiWOS:000227600300019-
dc.publisher.placeGreeceen_US
dc.identifier.scopusauthoridFang, X=12778042000en_US
dc.identifier.scopusauthoridChang, RC=7403713410en_US
dc.identifier.scopusauthoridYuen, WH=7102761282en_US
dc.identifier.scopusauthoridZee, SY=7004001733en_US

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