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Article: Electroacupuncture provides a new approach to neuroprotection in rats with induced glaucoma

TitleElectroacupuncture provides a new approach to neuroprotection in rats with induced glaucoma
Authors
Issue Date2005
PublisherMary Ann Liebert, Inc Publishers. The Journal's web site is located at http://www.liebertpub.com/acm
Citation
Journal Of Alternative And Complementary Medicine, 2005, v. 11 n. 2, p. 315-322 How to Cite?
AbstractObjectives: To investigate, using multifocal electroretinogram (mfERG), the effect of electroacupuncture (EA) on retinal function in rats with experimental glaucoma. Design and subjects: Glaucoma was induced in the right eyes of 15 adult female Sprague-Dawley rats by laser photocoagulation for three quarters of the perilimbal and episcleral vessels. The left eye of each rat was used as the control. The animals were divided into 3 groups: no treatment (non-EA control group), 2 Hz EA group, and 100 Hz EA group. EA treatment at different frequencies can produce different levels of analgesia and hence the effect of EA with different frequencies on glaucoma treatment was investigated. Both eyes of each rat in the EA experimental groups received 3 EA treatment sessions each week for 4 weeks. The retinal function was measured using mfERG after 4 weeks of EA treatment. Results: There was no significant difference in the amplitude (both N1 trough and P1 peak) of mfERG first- order kernel response between the treatment and control groups. In determining the waveform characteristics by the ratio of N1 amplitude to P1 amplitude (N/P ratio), obvious differences were found in the N/P ratio between the control eyes and the glaucoma eyes in the non-EA group and the 100 Hz EA treatment group, but similar values in the N/P ratio were observed between the control eyes and the glaucoma eyes in the 2 Hz EA treatment group. The waveform from the eyes with glaucoma was deformed in both the non-EA group and the 100 Hz EA group, but the waveform from the glaucomatous eye was preserved in the 2 Hz EA group. Conclusions: Application of EA at 2 Hz provides neuroprotection by preserving retinal function in rats with experimental glaucoma. Low frequency EA may be an alternative therapy in the treatment of glaucoma. © Mary Ann Liebert, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/149633
ISSN
2015 Impact Factor: 1.395
2015 SCImago Journal Rankings: 0.475
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorChan, HHLen_US
dc.contributor.authorLeung, MCPen_US
dc.contributor.authorSo, KFen_US
dc.date.accessioned2012-06-26T05:56:18Z-
dc.date.available2012-06-26T05:56:18Z-
dc.date.issued2005en_US
dc.identifier.citationJournal Of Alternative And Complementary Medicine, 2005, v. 11 n. 2, p. 315-322en_US
dc.identifier.issn1075-5535en_US
dc.identifier.urihttp://hdl.handle.net/10722/149633-
dc.description.abstractObjectives: To investigate, using multifocal electroretinogram (mfERG), the effect of electroacupuncture (EA) on retinal function in rats with experimental glaucoma. Design and subjects: Glaucoma was induced in the right eyes of 15 adult female Sprague-Dawley rats by laser photocoagulation for three quarters of the perilimbal and episcleral vessels. The left eye of each rat was used as the control. The animals were divided into 3 groups: no treatment (non-EA control group), 2 Hz EA group, and 100 Hz EA group. EA treatment at different frequencies can produce different levels of analgesia and hence the effect of EA with different frequencies on glaucoma treatment was investigated. Both eyes of each rat in the EA experimental groups received 3 EA treatment sessions each week for 4 weeks. The retinal function was measured using mfERG after 4 weeks of EA treatment. Results: There was no significant difference in the amplitude (both N1 trough and P1 peak) of mfERG first- order kernel response between the treatment and control groups. In determining the waveform characteristics by the ratio of N1 amplitude to P1 amplitude (N/P ratio), obvious differences were found in the N/P ratio between the control eyes and the glaucoma eyes in the non-EA group and the 100 Hz EA treatment group, but similar values in the N/P ratio were observed between the control eyes and the glaucoma eyes in the 2 Hz EA treatment group. The waveform from the eyes with glaucoma was deformed in both the non-EA group and the 100 Hz EA group, but the waveform from the glaucomatous eye was preserved in the 2 Hz EA group. Conclusions: Application of EA at 2 Hz provides neuroprotection by preserving retinal function in rats with experimental glaucoma. Low frequency EA may be an alternative therapy in the treatment of glaucoma. © Mary Ann Liebert, Inc.en_US
dc.languageengen_US
dc.publisherMary Ann Liebert, Inc Publishers. The Journal's web site is located at http://www.liebertpub.com/acmen_US
dc.relation.ispartofJournal of Alternative and Complementary Medicineen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.rightsThis is a copy of an article published in the [Journal of Alternative and Complementary Medicine] © [2005] [copyright Mary Ann Liebert, Inc.]; [Journal of Alternative and Complementary Medicine] is available online at: http://www.liebertonline.com-
dc.subject.meshAnimalsen_US
dc.subject.meshElectroacupuncture - Methodsen_US
dc.subject.meshElectroretinographyen_US
dc.subject.meshFemaleen_US
dc.subject.meshGlaucoma - Physiopathology - Therapyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshTime Factorsen_US
dc.subject.meshVisual Fieldsen_US
dc.titleElectroacupuncture provides a new approach to neuroprotection in rats with induced glaucomaen_US
dc.typeArticleen_US
dc.identifier.emailSo, KF:hrmaskf@hkucc.hku.hken_US
dc.identifier.authoritySo, KF=rp00329en_US
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.1089/acm.2005.11.315en_US
dc.identifier.pmid15865499-
dc.identifier.scopuseid_2-s2.0-18444387155en_US
dc.identifier.hkuros105878-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-18444387155&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume11en_US
dc.identifier.issue2en_US
dc.identifier.spage315en_US
dc.identifier.epage322en_US
dc.identifier.isiWOS:000229002400018-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridChan, HHL=24774420300en_US
dc.identifier.scopusauthoridLeung, MCP=7201943351en_US
dc.identifier.scopusauthoridSo, KF=34668391300en_US

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