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Article: Loss of heterozygosity in multistage carcinogenesis of esophageal carcinoma at high-incidence area in Henan Province, China

TitleLoss of heterozygosity in multistage carcinogenesis of esophageal carcinoma at high-incidence area in Henan Province, China
Authors
Issue Date2005
PublisherBaishideng Publishing Group. The Journal's web site is located at http://www.wjgnet.com/1007-9327/index.htm
Citation
World Journal Of Gastroenterology, 2005, v. 11 n. 14, p. 2055-2060 How to Cite?
AbstractAim: Microsatellites are the repeated DNA sequences scattered widely within the genomes and closely linked with many important genes. This study was designed to characterize the changes of microsatellite DNA loss of heterozygosity (LOH) in esophageal carcinogenesis. Methods: Allelic deletions in 32 cases of matched precancerous, cancerous and normal tissues were examined by syringe microdissection under an anatomic microscope and microsatellite polymorphism analysis using 15 polymorphic markers on chromosomes 3p, 5q, 6p, 9p, 13q, 17p, 17q and 18q. Results: Microsatellite DNA LOH was observed in precancerous and cancerous tissues, except D9S1752. The rate of LOH increased remarkably with the lesions progressed from basal cell hyperplasia (BCH) to squamous cell carcinoma (SCC) (P<0.05). Three markers, D9S171, D13S260 and TP53, showed the highest incidence of LOH (>60%). LOH loci were different in precancerous and cancerous tissues. LOH in D3S1234 and TP53 was the common event in different lesions from the same patients. Conclusion: Microsatellite DNA LOH occurs in early stage of human esophageal carcinogenesis, even in BCH. With the lesion progressed, gene instability increases, the accumulation of this change may be one of the important mechanisms driving precancerous lesions to cancer. © 2005 The WJG Press and Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/149631
ISSN
2015 Impact Factor: 2.787
2015 SCImago Journal Rankings: 1.076
PubMed Central ID
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorAn, JYen_US
dc.contributor.authorFan, ZMen_US
dc.contributor.authorGao, SSen_US
dc.contributor.authorZhuang, ZHen_US
dc.contributor.authorQin, YRen_US
dc.contributor.authorLi, JLen_US
dc.contributor.authorHe, Xen_US
dc.contributor.authorTsao, GSWen_US
dc.contributor.authorWang, LDen_US
dc.date.accessioned2012-06-26T05:56:17Z-
dc.date.available2012-06-26T05:56:17Z-
dc.date.issued2005en_US
dc.identifier.citationWorld Journal Of Gastroenterology, 2005, v. 11 n. 14, p. 2055-2060en_US
dc.identifier.issn1007-9327en_US
dc.identifier.urihttp://hdl.handle.net/10722/149631-
dc.description.abstractAim: Microsatellites are the repeated DNA sequences scattered widely within the genomes and closely linked with many important genes. This study was designed to characterize the changes of microsatellite DNA loss of heterozygosity (LOH) in esophageal carcinogenesis. Methods: Allelic deletions in 32 cases of matched precancerous, cancerous and normal tissues were examined by syringe microdissection under an anatomic microscope and microsatellite polymorphism analysis using 15 polymorphic markers on chromosomes 3p, 5q, 6p, 9p, 13q, 17p, 17q and 18q. Results: Microsatellite DNA LOH was observed in precancerous and cancerous tissues, except D9S1752. The rate of LOH increased remarkably with the lesions progressed from basal cell hyperplasia (BCH) to squamous cell carcinoma (SCC) (P<0.05). Three markers, D9S171, D13S260 and TP53, showed the highest incidence of LOH (>60%). LOH loci were different in precancerous and cancerous tissues. LOH in D3S1234 and TP53 was the common event in different lesions from the same patients. Conclusion: Microsatellite DNA LOH occurs in early stage of human esophageal carcinogenesis, even in BCH. With the lesion progressed, gene instability increases, the accumulation of this change may be one of the important mechanisms driving precancerous lesions to cancer. © 2005 The WJG Press and Elsevier Inc. All rights reserved.en_US
dc.languageengen_US
dc.publisherBaishideng Publishing Group. The Journal's web site is located at http://www.wjgnet.com/1007-9327/index.htmen_US
dc.relation.ispartofWorld Journal of Gastroenterologyen_US
dc.rightsCreative Commons: Attribution 3.0 Hong Kong License-
dc.subject.meshAdulten_US
dc.subject.meshAgeden_US
dc.subject.meshCarcinoma, Basal Cell - Epidemiology - Genetics - Pathologyen_US
dc.subject.meshCarcinoma, Squamous Cell - Epidemiology - Genetics - Pathologyen_US
dc.subject.meshChina - Epidemiologyen_US
dc.subject.meshEsophageal Neoplasms - Epidemiology - Genetics - Pathologyen_US
dc.subject.meshFemaleen_US
dc.subject.meshHumansen_US
dc.subject.meshIncidenceen_US
dc.subject.meshLoss Of Heterozygosityen_US
dc.subject.meshMaleen_US
dc.subject.meshMicrosatellite Repeatsen_US
dc.subject.meshMiddle Ageden_US
dc.subject.meshNeoplasm Stagingen_US
dc.titleLoss of heterozygosity in multistage carcinogenesis of esophageal carcinoma at high-incidence area in Henan Province, Chinaen_US
dc.typeArticleen_US
dc.identifier.emailTsao, GSW:gswtsao@hkucc.hku.hken_US
dc.identifier.authorityTsao, GSW=rp00399en_US
dc.description.naturepublished_or_final_versionen_US
dc.identifier.doi10.3748/wjg.v11.i14.2055-
dc.identifier.pmid15810068-
dc.identifier.pmcidPMC4305771-
dc.identifier.scopuseid_2-s2.0-17444368340en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-17444368340&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume11en_US
dc.identifier.issue14en_US
dc.identifier.spage2055en_US
dc.identifier.epage2060en_US
dc.identifier.isiWOS:000208102600002-
dc.publisher.placeChinaen_US
dc.identifier.scopusauthoridAn, JY=22953119200en_US
dc.identifier.scopusauthoridFan, ZM=7402099547en_US
dc.identifier.scopusauthoridGao, SS=36079553800en_US
dc.identifier.scopusauthoridZhuang, ZH=7203003327en_US
dc.identifier.scopusauthoridQin, YR=7403100680en_US
dc.identifier.scopusauthoridLi, JL=8667440000en_US
dc.identifier.scopusauthoridHe, X=7404408065en_US
dc.identifier.scopusauthoridTsao, GSW=7102813116en_US
dc.identifier.scopusauthoridWang, LD=12242861000en_US

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