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Article: Survival, regeneration and functional recovery of motoneurons after delayed reimplantation of avulsed spinal root in adult rat

TitleSurvival, regeneration and functional recovery of motoneurons after delayed reimplantation of avulsed spinal root in adult rat
Authors
Issue Date2005
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yexnr
Citation
Experimental Neurology, 2005, v. 192 n. 1, p. 89-99 How to Cite?
AbstractWe have established that extensive reinnervation and functional recovery follow immediate reimplantation of avulsed ventral roots in adult rats. In the present study, we examined the consequences of reimplantation delayed for 2 weeks after avulsion of the C6 spinal root. Twelve and 20 weeks after delayed reimplantation, 57% and 53% of the motoneurons in the injured spinal segment survived. More than 80% of surviving motoneurons regenerated axons into the reimplanted spinal root. Cholinesterase-silver staining revealed axon terminals on endplates in the denervated muscles. The biceps muscles in reimplanted animals had atrophied less than those in animals with avulsion only, as indicated by muscle wet weight and histological appearance. After electrical stimulation of the motor cortex or the C6 spinal root, typical EMG signals were recorded in biceps of reimplanted animals. The latency of the muscle potential at 20 weeks was similar to that of sham-operated controls. Behavioral recovery was demonstrated by a grooming test and ipsilateral forepaw movements were well coordinated in both voluntary and automatic activities. These results demonstrate that ventral root reimplantation can protect severed motoneurons, enable the severed motoneurons to regenerate axons, and enhance the recovery of forelimb function even when it is delayed for 2 weeks after avulsion. © 2004 Elsevier Inc. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/149628
ISSN
2015 Impact Factor: 4.657
2015 SCImago Journal Rankings: 2.427
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorGu, HYen_US
dc.contributor.authorChai, Hen_US
dc.contributor.authorZhang, JYen_US
dc.contributor.authorYao, ZBen_US
dc.contributor.authorZhou, LHen_US
dc.contributor.authorWong, WMen_US
dc.contributor.authorBruce, ICen_US
dc.contributor.authorWu, WTen_US
dc.date.accessioned2012-06-26T05:56:15Z-
dc.date.available2012-06-26T05:56:15Z-
dc.date.issued2005en_US
dc.identifier.citationExperimental Neurology, 2005, v. 192 n. 1, p. 89-99en_US
dc.identifier.issn0014-4886en_US
dc.identifier.urihttp://hdl.handle.net/10722/149628-
dc.description.abstractWe have established that extensive reinnervation and functional recovery follow immediate reimplantation of avulsed ventral roots in adult rats. In the present study, we examined the consequences of reimplantation delayed for 2 weeks after avulsion of the C6 spinal root. Twelve and 20 weeks after delayed reimplantation, 57% and 53% of the motoneurons in the injured spinal segment survived. More than 80% of surviving motoneurons regenerated axons into the reimplanted spinal root. Cholinesterase-silver staining revealed axon terminals on endplates in the denervated muscles. The biceps muscles in reimplanted animals had atrophied less than those in animals with avulsion only, as indicated by muscle wet weight and histological appearance. After electrical stimulation of the motor cortex or the C6 spinal root, typical EMG signals were recorded in biceps of reimplanted animals. The latency of the muscle potential at 20 weeks was similar to that of sham-operated controls. Behavioral recovery was demonstrated by a grooming test and ipsilateral forepaw movements were well coordinated in both voluntary and automatic activities. These results demonstrate that ventral root reimplantation can protect severed motoneurons, enable the severed motoneurons to regenerate axons, and enhance the recovery of forelimb function even when it is delayed for 2 weeks after avulsion. © 2004 Elsevier Inc. All rights reserved.en_US
dc.languageengen_US
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yexnren_US
dc.relation.ispartofExperimental Neurologyen_US
dc.subject.meshAction Potentials - Physiologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBrachial Plexus Neuropathies - Physiopathology - Surgeryen_US
dc.subject.meshCell Survival - Physiologyen_US
dc.subject.meshDisease Models, Animalen_US
dc.subject.meshGrooming - Physiologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMotor Neurons - Cytology - Physiologyen_US
dc.subject.meshMovement - Physiologyen_US
dc.subject.meshMuscle, Skeletal - Innervation - Physiologyen_US
dc.subject.meshMuscular Atrophy - Etiology - Physiopathology - Surgeryen_US
dc.subject.meshNerve Regeneration - Physiologyen_US
dc.subject.meshNeural Conduction - Physiologyen_US
dc.subject.meshNeuromuscular Junction - Cytology - Physiologyen_US
dc.subject.meshRadiculopathy - Physiopathology - Surgeryen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshRecovery Of Function - Physiologyen_US
dc.subject.meshReplantation - Methodsen_US
dc.subject.meshSpinal Nerve Roots - Injuries - Physiology - Surgeryen_US
dc.subject.meshTime Factorsen_US
dc.titleSurvival, regeneration and functional recovery of motoneurons after delayed reimplantation of avulsed spinal root in adult raten_US
dc.typeArticleen_US
dc.identifier.emailWu, WT:wtwu@hkucc.hku.hken_US
dc.identifier.authorityWu, WT=rp00419en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/j.expneurol.2004.10.019en_US
dc.identifier.pmid15698622-
dc.identifier.scopuseid_2-s2.0-13444261158en_US
dc.identifier.hkuros98262-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-13444261158&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume192en_US
dc.identifier.issue1en_US
dc.identifier.spage89en_US
dc.identifier.epage99en_US
dc.identifier.isiWOS:000227147200010-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridGu, HY=11339561900en_US
dc.identifier.scopusauthoridChai, H=35918658800en_US
dc.identifier.scopusauthoridZhang, JY=35492256700en_US
dc.identifier.scopusauthoridYao, ZB=7401467890en_US
dc.identifier.scopusauthoridZhou, LH=7404125592en_US
dc.identifier.scopusauthoridWong, WM=7403972413en_US
dc.identifier.scopusauthoridBruce, IC=35612490700en_US
dc.identifier.scopusauthoridWu, WT=7407081122en_US

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