File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Potential roles of alzheimer precursor protein A4 and β-amyloid in survival and function of aged spinal motor neurons after axonal injury

TitlePotential roles of alzheimer precursor protein A4 and β-amyloid in survival and function of aged spinal motor neurons after axonal injury
Authors
Issue Date2003
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/34828
Citation
Journal Of Neuroscience Research, 2003, v. 73 n. 4, p. 557-564 How to Cite?
AbstractTo study the potential role of Alzheimer precursor protein A4 (APP) and β-amyloid (A/β) on aging motor neuron survival, expression of APP, A/β, and choline acetyltransferase (ChaT) were investigated in aged rats after either distal axotomy or root avulsion injury. Approximately 45% in number of total aged spinal motor neuron were normally APP-positive. A/β-positive neurites were observed normally in the spinal ventral horn of aged rats. After distal axotomy, without apparent neurodegeneration such as cell loss and decreased ChaT-immunoreactivity, increased levels of APP expression were observed in the spinal cords of aged rats post-injury. In contrast, after avulsion, expression of APP and A/β were downregulated in the spinal ventral horn of aged rats, and marked loss of spinal motor neurons and downregulated ChaT expression were observed. Our data indicate that APP and A/β might play beneficial roles in neuronal survival of aged spinal motor neurons after axonal injury. © 2003 Wiley-Liss, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/149619
ISSN
2015 Impact Factor: 2.689
2015 SCImago Journal Rankings: 1.261
ISI Accession Number ID
References

 

DC FieldValueLanguage
dc.contributor.authorXie, Yen_US
dc.contributor.authorYao, Zen_US
dc.contributor.authorChai, Hen_US
dc.contributor.authorWong, WMen_US
dc.contributor.authorWu, Wen_US
dc.date.accessioned2012-06-26T05:56:08Z-
dc.date.available2012-06-26T05:56:08Z-
dc.date.issued2003en_US
dc.identifier.citationJournal Of Neuroscience Research, 2003, v. 73 n. 4, p. 557-564en_US
dc.identifier.issn0360-4012en_US
dc.identifier.urihttp://hdl.handle.net/10722/149619-
dc.description.abstractTo study the potential role of Alzheimer precursor protein A4 (APP) and β-amyloid (A/β) on aging motor neuron survival, expression of APP, A/β, and choline acetyltransferase (ChaT) were investigated in aged rats after either distal axotomy or root avulsion injury. Approximately 45% in number of total aged spinal motor neuron were normally APP-positive. A/β-positive neurites were observed normally in the spinal ventral horn of aged rats. After distal axotomy, without apparent neurodegeneration such as cell loss and decreased ChaT-immunoreactivity, increased levels of APP expression were observed in the spinal cords of aged rats post-injury. In contrast, after avulsion, expression of APP and A/β were downregulated in the spinal ventral horn of aged rats, and marked loss of spinal motor neurons and downregulated ChaT expression were observed. Our data indicate that APP and A/β might play beneficial roles in neuronal survival of aged spinal motor neurons after axonal injury. © 2003 Wiley-Liss, Inc.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/34828en_US
dc.relation.ispartofJournal of Neuroscience Researchen_US
dc.subject.meshAging - Pathologyen_US
dc.subject.meshAmyloid Beta-Peptides - Pharmacologyen_US
dc.subject.meshAmyloid Beta-Protein Precursor - Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAxotomy - Methodsen_US
dc.subject.meshCell Survival - Drug Effects - Physiologyen_US
dc.subject.meshCholine O-Acetyltransferase - Metabolismen_US
dc.subject.meshDisease Models, Animalen_US
dc.subject.meshImmunohistochemistry - Methodsen_US
dc.subject.meshMaleen_US
dc.subject.meshMotor Neurons - Drug Effects - Pathologyen_US
dc.subject.meshRadiculopathy - Metabolism - Pathologyen_US
dc.subject.meshRatsen_US
dc.subject.meshRats, Sprague-Dawleyen_US
dc.subject.meshSpinal Cord - Metabolism - Pathologyen_US
dc.subject.meshSpinal Injuries - Pathologyen_US
dc.subject.meshTime Factorsen_US
dc.titlePotential roles of alzheimer precursor protein A4 and β-amyloid in survival and function of aged spinal motor neurons after axonal injuryen_US
dc.typeArticleen_US
dc.identifier.emailWu, W:wtwu@hkucc.hku.hken_US
dc.identifier.authorityWu, W=rp00419en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/jnr.10667en_US
dc.identifier.pmid12898540-
dc.identifier.scopuseid_2-s2.0-0042172835en_US
dc.identifier.hkuros85079-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-0042172835&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume73en_US
dc.identifier.issue4en_US
dc.identifier.spage557en_US
dc.identifier.epage564en_US
dc.identifier.isiWOS:000184521000014-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridXie, Y=7403958873en_US
dc.identifier.scopusauthoridYao, Z=7401467890en_US
dc.identifier.scopusauthoridChai, H=35918658800en_US
dc.identifier.scopusauthoridWong, WM=7403972413en_US
dc.identifier.scopusauthoridWu, W=7407081122en_US

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats